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C3A.BLiA-Pde6b+/J
Stock No: 001912
  • Congenic
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  • Overview
  • Details
    • Detailed Description
    • Development
    • Expression Data
    • Control Suggestions
    • Selected References
  • Genetics
  • Disease/Phenotype
    • Disease Terms
    • Research Areas By Phenotype
    • Mammalian Phenotype Terms by Genotype
    • References
  • Technical Support
    • Genotyping Protocols
    • Breeding Considerations
    • Mating System
    • Breeder Pairs
    • Appearance
    • Citation
    • Animal Health Reports
    • Contact Technical Support
  • Pricing & Availability
    • Price
    • Payment Terms
  • Terms Of Use
  • Related Strains

Overview

Also Known As:C3H/f<+/+>

In this congenic strain, the wild type Pde6b allele from C57BL/LiA was introgressed onto the C3Hf/HeA background. Retinal degeneration 1 (Pde6brd1) is a spontaneous mutation that is present in multiple inbred strains, including the C3H substrains. Strains that carry rd1 lack rod cells. This strain provides a sighted C3H mouse for use in research studies that require normal vision.

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Genetic overview

Genetic Background Generation
F?+27
(2020-04-23 00:00:00)

Pde6b+

Allele Type Gene Symbol Gene Name
Not Applicable Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
View Genetics

Research Applications

  • Mouse/Human Gene Homologs
  • Sensorineural Research
View All Research Applications

Base Price

Starting at:

$130.95 Domestic price for female
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Details

Detailed Description

In this congenic strain, the wild type Pde6b allele from C57BL/LiA was introgressed onto the C3Hf/HeA background. Retinal degeneration 1 (Pde6brd1) is a spontaneous mutation that is present in multiple inbred strains, including the C3H substrains. Strains that carry rd1 lack rod cells. This strain provides a sighted C3H mouse for use in research studies that require normal vision. This strain also does not have the nob5 allele of Gpr179 (Chang, 2015) or the Clcc1m1J allele found in C3H/HeSn subline mice.

Development

This strain was developed in the laboratory of Willem J. de Grip at Erasmus Universiteit, Rotterdam, the Netherlands. An initial cross of C3Hf/HeA with C57BL/LiA was followed by 8 generations of backcrossing to C3Hf/HeA to introgress the wild type Pde6b allele of C57BL/LiA onto the C3Hf/HeA background. The heterozygous progeny of the last backcross were intercrossed to produce homozygous wild type (Pde6b+/Pdeb+) mice, after which the strain was maintained by sib inbreeding. The strain had exceeded 30 generations of sibling mating when it was sent to The Jackson Laboratory in 1991. (Schalken et al., 1990 and TJL documentation)

Additional backgrounds available: using this strain as the donor, the wild type allele of Pde6b was backcrossed for 10 generations to C3H/HeSnJ. This was done for the purpose of generating a hardier control/background strain for use in studies of additional retinal degeneration mutations. The product of this backcross, C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648), is now maintained by sib mating.

Expression Data

Expressed Gene Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory
Site of ExpressionRetina.

Control Suggestions

  • This strain can be used as a normal, sighted control for C3A Pde6brd1.O20-RdsRd2 (001957) and for C3A.BLiA-+Pde6b.O20-RdsRd2 (001979). For applications related to Pde6brd1, this strain serves as a control for C3H/HeJ (000659).

Additional Information

  • Considerations for Choosing Controls

Selected References

  • Chang B. 2015. Survey of the nob5 mutation in C3H substrains. Mol Vis 21:1101-5PubMed: 26396487MGI: J:224435
View All References

Genetics

Pde6b+

Allele Symbol: Pde6b+

Allele Name wild type
Allele Type Not Applicable
Allele Synonym(s)
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)
Expressed GenePde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory
Site of ExpressionRetina.
Strain of Origin Not Applicable
Chromosome 5

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Pde6b+ related

  • Mouse/Human Gene Homologs
    • retinitis pigmentosa, wildtype
  • Sensorineural Research
    • Retinal Degeneration
      • wild-type

Mammalian Phenotype Terms by Genotype

References

  • Chang B. 2015. Survey of the nob5 mutation in C3H substrains. Mol Vis 21:1101-5PubMed: 26396487MGI: J:224435

Additional References

  • Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9PubMed: 2137350MGI: J:109932
  • Xue Y; Shen SQ; Corbo JC; Kefalov VJ. 2015. Circadian and light-driven regulation of rod dark adaptation. Sci Rep 5:17616PubMed: 26626567MGI: J:239226

Additional - Pde6b+ related

Technical Support

CONTACT TECHNICAL SUPPORT
  • Genotyping Protocols

    • Genotyping resources and troubleshooting
  • Breeding Considerations

    Malocclusion occurs occasionally in this strain.

    • Additional Breeding and Husbandry Support
  • Mating System

    • Sibling x Sibling
  • Appearance

    • agouti
      Related Genotype: A/A
  • Citation

    When using the C3A.BLiA-Pde6b+/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001912 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

Availability Varies
  • Domestic
  • International

Live Mouse

Age Genotype Price
weeks

Cryorecovery - Pricing

Service/Product Description Price
Wild-type forPde6b

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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Licensing Information

Phone: 207-288-6470
Email: TechTran@jax.org

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