In this congenic strain, the wild type Pde6b allele from C57BL/LiA was introgressed onto the C3Hf/HeA background. Retinal degeneration 1 (Pde6brd1) is a spontaneous mutation that is present in multiple inbred strains, including the C3H substrains. Strains that carry rd1 lack rod cells. This strain provides a sighted C3H mouse for use in research studies that require normal vision.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
In this congenic strain, the wild type Pde6b allele from C57BL/LiA was introgressed onto the C3Hf/HeA background. Retinal degeneration 1 (Pde6brd1) is a spontaneous mutation that is present in multiple inbred strains, including the C3H substrains. Strains that carry rd1 lack rod cells. This strain provides a sighted C3H mouse for use in research studies that require normal vision. This strain also does not have the nob5 allele of Gpr179 (Chang, 2015) or the Clcc1m1J allele found in C3H/HeSn subline mice.
This strain was developed in the laboratory of Willem J. de Grip at Erasmus Universiteit, Rotterdam, the Netherlands. An initial cross of C3Hf/HeA with C57BL/LiA was followed by 8 generations of backcrossing to C3Hf/HeA to introgress the wild type Pde6b allele of C57BL/LiA onto the C3Hf/HeA background. The heterozygous progeny of the last backcross were intercrossed to produce homozygous wild type (Pde6b+/Pdeb+) mice, after which the strain was maintained by sib inbreeding. The strain had exceeded 30 generations of sibling mating when it was sent to The Jackson Laboratory in 1991. (Schalken et al., 1990 and TJL documentation)
Additional backgrounds available: using this strain as the donor, the wild type allele of Pde6b was backcrossed for 10 generations to C3H/HeSnJ. This was done for the purpose of generating a hardier control/background strain for use in studies of additional retinal degeneration mutations. The product of this backcross, C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648), is now maintained by sib mating.
Expressed Gene | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory |
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Site of Expression | Retina. |
Allele Name | wild type |
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Allele Type | Not Applicable |
Allele Synonym(s) | |
Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
Gene Synonym(s) | |
Expressed Gene | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory |
Site of Expression | Retina. |
Strain of Origin | Not Applicable |
Chromosome | 5 |
Malocclusion occurs occasionally in this strain.
When using the C3A.BLiA-Pde6b+/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001912 in your Materials and Methods section.
Service/Product | Description | Price |
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Wild-type forPde6b |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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