BALB/cGaJ

Stock number: 001905
Strain synonyms: BALB Gates
Research areas: Research Tools

Detailed description

The BALB/cGaJ inbred strain has been reported by donating investigator Allen Gates to have high fertility relative to many inbred strains, including BALB/cByJ, delayed reproductive senility to at least 12 months of age, excellent monoclonal antibody production, and delay of male aggression to approximately 5 months of age.

Development

Inbreeding of BALB/c began in 1922 by MacDowell and mice were transferred to Snell in 1932 when the line was at generation F26, then to Heston and to Andervont in 1935 when the strain was at approximately F34 then to The Cancer Research Genetics Laboratory of The University of California at Berkley (Crgl) in 1950 when the strain was at generation F60, then to Allen Gates (Ga) in 1960 when the strain was at generation F72, then to Hugh McDevitt (Mcd) in 1970 when the strain was at generation F72+20, then back to Allen Gates in 1971 when the strain was at generation F72+24. In 1986 this strain reached generation F72+57 and in 1989 mice were sent from Allen Gates to The Jackson Laboratory at generation F72+66 (cumulative generation F138). These were re-derived and expanded by sibling breeding and cryopreserved.