STOCK Tsv/J

Stock number: 001829
Product name: tail short variable
Research areas: Developmental Biology Research

Description

These mice carry the spontaneous Tsv mutation and are characterized by a reduction deformity of the tail, growth retardation, and, in adults, a mild anemia.

Detailed description

A new mouse mutant, tail short variable (Tsv) produces a reduction deformity of the tail, growth retardation, and, in adults, a mild anemia. Genetic and embryological studies show that on all genetic backgrounds there is variable viability of Tsv/Tsv and Tsv/+ and phenotypic overlap within these and with +/+. A modifier is located to a short segment of chromosome 7, which alters the tail length of Tsv/+ mice up to 15%. The modifier, Tsv, and a coat texture mutant come from the same wild Peru mouse. The tail deformity is associated with, and may be caused by, a vascular disruption of the caudal aorta starting on day 11 of gestation. Thus, Tsv appears to be different from each of the thirty known mouse mutants involving the tail. These mice maybe useful as a mouse model for human conditions involving transverse terminal limb defects such as Moebius and de Lange syndromes. (Seller MJ; Wallace ME. 1993. Teratology 48 (4) 383-91.)

Allele

Symbol: Tsv
Name: tail short variable
MGI accession ID: MGI:1861632
Generation method: Spontaneous
Marker symbol: Tsv
Marker name: variable short tail
Chromosome: UN
Strain of origin: (Peru-Wallace x H STOCK)F1
General note: This mutation arose spontaneously in a stock derived from wild mice captured in Peru.