These mice carry the spontaneous ge mutation and are characterized by coat color dilution, pale ears, feet and tail.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | ge | greige |
This recessive coat color mutation arose in the DBA/2J inbred strain. Homozygotes on the DBA/2J background are easily identifiable at 6 days of age by coat color dilution, pale ears, feet and tail. Eye color is not affected. Homozygotes are not deaf. Adult homozygotes may develop coat color mosaicism and in two instances the entire coat color reverted to nearly full color. Homozygotes are viable, fertile, produce all ge/ge offspring, and on an agouti (C3HeB/FeJ) background are extremely difficult to identify. There may be a barely discernable lightening of agouti hair on the belly or a fleck of white on the dorsum. Homozygotes on the C57BL/6J background are slightly dilute and closely resemble sepia. Coat color may be considerably lighter than normal on the belly with variable flecking on the dorsum. Occasionally the nose appears grizzled. Matings between homozygotes on either of these two backgrounds may produce some phenotypically normal appearing progeny
This recessive coat color mutation arose in the DBA/2J inbred strain in 1988 and has been located on Chromosome 1.
When using the greige mouse strain in a publication, please cite the originating article(s) and include JAX stock #001789 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for ge |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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