BALB/cBy-Krt71^Ca-10J/J

Stock number: 001755
Product name: caracul 10 Jackson
Research areas: Dermatology Research

Detailed description

Sequence analysis of Krt2-6g, now Krt71, identified the spontaneous deletion of codon 140, comprised of nucleotides 418, 419, and 420 (CAA). The deleted codon predicted an asparagine in the alpha-helical rod domain. This molecular lesion is the same that has been identified in Krt2-6g^Ca-Rin, Ca^J, and Ca^9J.

Allele

Symbol: Krt71^Ca-10J
Name: caracul 10 Jackson
MGI accession ID: MGI:1856489
Generation method: Spontaneous
Marker symbol: Krt71
Marker name: keratin 71
Chromosome: 15
Strain of origin: BALB/cBy
Molecular note: Sequence analysis identified the spontaneous deletion of asparagine codon 139 or 140, through the deletion of CAA / ACA / AAC from the AACAACAA sequence at codong nucleotides 415-422. The deleted codon is located in the alpha-helical rod domain. This molecular lesion is the same that has been identified in Krt71^Ca-Rin, Krt71^Ca-J, and Krt71^Ca-9J.