The AXB and BXA set of RI strains are useful in the genetic analysis of complex diseases. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin. AXB and BXA strains are derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains.
Read More +The AXB and BXA set of RI strains are useful in the genetic analysis of several complex diseases including cardiovascular disease, diabetes, cancer, cleft palate, and hydrocephalus. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin.
The strain distribution pattern (SDP) for the AXB RI strains is available through the Mouse Genome Informatics
Contributed Data Sets and Gene Network.
Additional tools and information are presented through the Mouse Phenome Database
Specialized Strain Panel Query Form, and
Gene Network .
The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.
Currently there are no related genes or alleles for this strain.
When using the AXB8/PgnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001679 in your Materials and Methods section.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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