These mice carry a spontaneous mutation at the Crygd locus characterized by cataracts.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Crygd | crystallin, gamma D |
Both homozygous and heterozygous mutant mice develop cataracts by one month of age. The cataracts demonstrate prominent reactive fibrous proliferation surrounding extruded lens cortical fragments, accompanied by focal, mild lymphocytic infiltration. Homozygous mice have eyes that are smaller than wildtype, whereas the heterozygote mouse has an eye size that is intermediate.
CrygdLop12 is an autosomal, semidominant, spontaneous mutation discovered in a cross between mice of strains BALB/cJ and SJL/J at The Jackson Laboratory. The mutation was backcrossed once to BALB/cJ, followed by more than 20 generations of sibling matings.
Allele Name | lens opacity 12 |
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Allele Type | Spontaneous |
Allele Synonym(s) | Lop12 |
Gene Symbol and Name | Crygd, crystallin, gamma D |
Gene Synonym(s) | |
Strain of Origin | BALB/cJ x SJL/J |
Chromosome | 1 |
General Note | Both homozygous and heterozygous mutant mice develop cataracts by one month of age. The catarats demonstrate prominent reactive fibrous proliferation surrounding extruded lens cortical fragments, accompanied by focal, mild lymphocytic infiltration. Homozygous mice have eyes that are smaller than wildtype, whereas the heterozygote mouse has an eye size that is intermediate (J:60856). |
Molecular Note | A G-to-A transition (C-to-T on forward strand) at coding nucleotide position 470 in exon 3 creates a premature termination signal by changing tryptophan codon 157 to a stop codon (p.W157*) and results in a truncated protein after amino acid 156. |
When using the lens opacity 12 mouse strain in a publication, please cite the originating article(s) and include JAX stock #001646 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous forÊCrygd<Lop12>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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