These congenic mice carry the carboxylesterase 1C allele (Ces1cb) and the carboxylesterase 1E deficient allele (Ces1eh) from the YBR inbred strain on a C57BL/6J genetic background.Read More +
TThe carboxylesterase 1E (egasyn) gene affects the processing of beta-glucuronidase, which is segregated to lysosomes. In carboxylesterase 1E-positive mice lysosomal beta-glucuronidase from liver has a mean pI of 5.9 with a minor proportion at pI 5.4, whereas in these carboxylesterase 1E-negative mice the proportion of the two lysosomal forms is reversed.
Ces1cb and Ces1eh (formerly called Eg0) were backcrossed from YBR onto C57BL/6 until N15 then sibling mated. (Swank et al., 1986.)