B6.YBR-Ces1c^b Ces1e^h/CvJ

Stock number: 001601
Product name: B6 Eg⁰/Eg⁰

Description

These congenic mice carry the carboxylesterase 1C allele (Ces1c^b) and the carboxylesterase 1E deficient allele (Ces1e^h) from the YBR inbred strain on a C57BL/6J genetic background.

Detailed description

TThe carboxylesterase 1E (egasyn) gene affects the processing of beta-glucuronidase, which is segregated to lysosomes. In carboxylesterase 1E-positive mice lysosomal beta-glucuronidase from liver has a mean pI of 5.9 with a minor proportion at pI 5.4, whereas in these carboxylesterase 1E-negative mice the proportion of the two lysosomal forms is reversed.

Development

Ces1c^b and Ces1e^h (formerly called Eg⁰) were backcrossed from YBR onto C57BL/6 until N15 then sibling mated. (Swank et al., 1986.)

Allele

Symbol: Ces1e^h
Name: deficient
MGI accession ID: MGI:3662619
Generation method: Spontaneous
Synonyms: Eg⁰
Marker symbol: Ces1e
Marker name: carboxylesterase 1E
Marker synonyms: ACAT; CE-1; CEH; Ces1; CES2; Eg; egasyn; Es22; Es-22; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
Chromosome: 8
Strain of origin: Not Specified

Allele

Symbol: Ces1c^b
Name: variant b
MGI accession ID: MGI:7596337
Generation method: Not Applicable
Attributes: Not Applicable
Synonyms: Es-1^b
Marker symbol: Ces1c
Marker name: carboxylesterase 1C
Marker synonyms: ACAT; CE-1; CEH; CES2; Ces-N; Ee-1; Es1; Es-1; Es2; Es-4; Es-N; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
Chromosome: 8
Strain of origin: various
Molecular note: One of two codominant electrophoretic variant b (the other being variant a) is present in various inbred strains.

Allele

MGI accession ID: MGI:95420
Marker symbol: Ces1c
Marker name: carboxylesterase 1C
Marker synonyms: ACAT; CE-1; CEH; CES2; Ces-N; Ee-1; Es1; Es-1; Es2; Es-4; Es-N; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
Chromosome: 8