A re-mutation to mottled agouti (am) occurred in the C3H chromosome of a (C3H/HeJ X C57B/6) F1 male. The mutation generally produces a mottled coat in both the heterozygote and homozygote but it can range in color from almost extreme non-agouti with little ticking to full agouti with no mottling.
|Allele Name||mottled agouti Jackson|
|Allele Type||Spontaneous (Hypomorph)|
|Gene Symbol and Name||a, nonagouti|
|Strain of Origin||(C57BL/6J x C3H/HeJ)F1|
|General Note||This allele is dominant to a. This mutation at the agouti locus arose in a C57BL/6J x C3H/HeJ F1 male. As with am the variation in color is influenced by the genome of the dam (J:16570).|
|Molecular Note||This mutation appears to represent a regulatory mutation that down-regulates agouti expression.|