Mice homozygous or heterozygous for the Oca2p-un+5J allele exhibit normal hair and eye pigmentation. Heterozygotes also carrying a mutant Oca2p allele that, when homozygous, produces a recognizable pink-eyed dilution phenotype, can be distinguished by test-crossing them to known heterozygotes or pink-eyed dilution mice. Homozygotes and heterozygotes for this revertant allele are phenotypically indisting uishable from wild-type.
The C57BL/6J-Oca2p-un+5J strain was created by mating Oca2p-un individuals having at least 50% wild-type pigmentation to nonmosaic Oca2p-un/Oca2p-un sibs. Pigmented offspring of this mating were intercrossed to obtain mice homozygous for the revertant allele.
|Allele Name||pink-eyed dilution unstable wild-type revertant 5 Jackson|
|Gene Symbol and Name||Oca2, oculocutaneous albinism II|
|Strain of Origin||C57BL/6J-Oca2p-un|
|Molecular Note||Removal, presumably by unequal homologous recombination, of an ~70 kb DNA duplication derived from retroviral-like intracisternal A particles that characterizes pun, restores wild-type coat pigmentation.|
When maintaining a live colony, homozygous mice may be bred together.
When using the revertant 5 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #001513 in your Materials and Methods section.