These mice carry a spontaneous revertant mutation at the Oca2 locus.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Oca2 | oculocutaneous albinism II |
Homozygotes and heterozygotes for this revertant allele are phenotypically indistinguishable from wild-type.
Mice homozygous or heterozygous for Oca2p-un+6J exhibit normal hair and eye pigmentation. Heterozygotes also carrying a mutant Oca2p allele that, when homozygous, produces a recognizable pink-eyed dilution phenotype can be distinguished by test-crossing them to known heterozygotes or pink-eyed dilution mice.
The C57BL/6J-Oca2p-un+6J strain was created by mating Oca2p-un individuals having at least 50% wild-type pigmentation to nonmosaic Oca2p-un/Oca2p-un sibs. Pigmented offspring of this mating were intercrossed to obtain mice homozygous for the revertant allele.
Allele Name | pink-eyed dilution unstable wild-type revertant 6 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | pun+6J |
Gene Symbol and Name | Oca2, oculocutaneous albinism II |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J-Oca2p-un |
Chromosome | 7 |
Molecular Note | Removal, presumably by unequal homologous recombination, of an ~70 kb DNA duplication derived from retroviral-like intracisternal A particles that characterizes pun, restores wild-type coat pigmentation. |
Mice homozygous or heterozygous for Oca2p-un+6J exhibit normal hair and eye pigmentation. Heterozygotes also carrying a mutant Oca2p allele that, when homozygous, produces a recognizable pink-eyed dilution phenotype can be distinguished by test-crossing them to known heterozygotes or pink-eyed dilution mice.
When using the revertant 6 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #001499 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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