Overview

Mice of this stock carry the “low” allele of the Igl1-r gene, which exhibit reduced levels of IGL1, along with the immunoglobulin lambda chain b variant allele (Igl-1^b ) and mahoganoid (Mgrn1^md).

Genetic overview

Genetic Background	Generation

Mgrn1^md

Allele Type	Gene Symbol	Gene Name
Spontaneous	Mgrn1	mahogunin, ring finger 1

Igl-1^b

Allele Type	Gene Symbol	Gene Name
Not Applicable	Igl-1	immunoglobulin lambda chain, cluster 1

Marker(s)

	Marker Symbol	Marker Name
	Igl1-r	immunoglobulin lambda chain regulator

View Genetics

Research Applications

Immunology, Inflammation and Autoimmunity Research
Dermatology Research

View All Research Applications

Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

Mice of this stock carry the “low” allele of the Igl1-r gene, which exhibit reduced levels of IGL1, along with the immunoglobulin lambda chain b variant allele (Igl-1^b ) and mahoganoid (Mgrn1^md).

Development

Mahoganoid (Mgrn1^md) arose spontaneously on strain C3H/HeJ at the Jackson Laboratory in 1957. The Igl-1^b allele at the immunoglobulin lamba chain cluster 1 locus is found in strains SJL, YBR, BSVS and others and the Igl1-r^lo allele occurs in strains SJL, BSVS and others. In 1972 Dr. M. C. Green received the fused phalanges (Fbn2^fp) stock from Dr. Katrina Hummel. Fused phalanges arose spontaneously in strain C3HeB/FeHu. The stock Dr. Green received had been crossed once to C57BL/6J and it was then brother x sister bred to F20 in 1976. At F18 the stock was given to Dr. Muriel Davisson and it was continued to be inbred to F21 when a fused phalanges male was outcrossed to a homozygous mahoganoid (Mgrn1^md) female. This mahoganoid female was the N2 offspring of a backcross that began with a mating of C57BL/6J x C3H/He-Mgrn1^md/+ from which an F1 was bred back to a C3H/HeJ-Mgrn1^md/Mgrn1^md, which was at F69. The N2 homozygous female resulting from this breeding was bred with the F21 fused phalanges male and their offspring were bred brother x sister to F20. At that point, a mahoganoid male was outcrossed to an Lyst^bg homozygous female on a congenic SJL/J background at generation N12F4 from Dr. John Roths. The resulting stock was sibling mated and a homozygous mahoganoid female was backcrossed to an SJL/J male. The stock was then bred as homozygous for mahoganoid (Mgrn1^md),Igl-1^b and Igl1-r^lo all on chromosome 16. It was cryopreserved in 1991 by mating homozygotes at F27 and F28.

Genetics

Mgrn1^md

Allele Symbol: Mgrn1^md

Allele Name	mahoganoid
Allele Type	Spontaneous
Allele Synonym(s)	md
Gene Symbol and Name	Mgrn1, mahogunin, ring finger 1
Gene Synonym(s)
Strain of Origin	C3H/HeJ
Chromosome	16
General Note	The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrn^mg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791).
Molecular Note	The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice.

Igl-1^b

Allele Symbol: Igl-1^b

Allele Name	b variant
Allele Type	Not Applicable
Allele Synonym(s)
Gene Symbol and Name	Igl-1, immunoglobulin lambda chain, cluster 1
Gene Synonym(s)
Strain of Origin	Not Applicable
Chromosome	16

Igl1-r

Marker Symbol: Igl1-r

Marker Synonym(s)
Chromosome(s)	16

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Igl-1^b related

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genotype: Mgrn1^md related

Dermatology Research
- Color and White Spotting Defects
- Skin and Hair Texture Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Mgrn1^md/Mgrn1^md
C3H/HeJ-Mgrn1/J

integument phenotype

darkened coat color
- reduced amount of yellow pigment causing a dark brown appearance

pigmentation phenotype

darkened coat color
- reduced amount of yellow pigment causing a dark brown appearance

References

Additional - Igl-1^b related

Additional - Igl1-r related

Additional - Mgrn1^md related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Citation
When using the STOCK Mgrn1^md Igl-1^b Igl1-r^lo/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001277 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Homozygous for Mgrn1<md>, Igl-1<b>, and Igl1-r<lo>, 1 pair minimum

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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Genetic overview

Marker(s)

Research Applications

Base Price

Detailed Description

Development

Mgrn1md

Allele Symbol: Mgrn1md

Igl-1b

Allele Symbol: Igl-1b

Igl1-r

Marker Symbol: Igl1-r

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Igl-1b related

Genotype: Mgrn1md related

Mammalian Phenotype Terms by Genotype

Genotype: Mgrn1md/Mgrn1mdC3H/HeJ-Mgrn1/J

integument phenotype

pigmentation phenotype

References

Additional - Igl-1b related

Additional - Igl1-r related

Additional - Mgrn1md related

Genotyping Protocols

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Mgrn1^md

Allele Symbol: Mgrn1^md

Igl-1^b

Allele Symbol: Igl-1^b

Genotype: Igl-1^b related

Genotype: Mgrn1^md related

Genotype: Mgrn1^md/Mgrn1^md
C3H/HeJ-Mgrn1/J

Additional - Igl-1^b related

Additional - Mgrn1^md related