Mice of this stock carry the “low” allele of the Igl1-r gene, which exhibit reduced levels of IGL1, along with the immunoglobulin lambda chain b variant allele (Igl-1b ) and mahoganoid (Mgrn1md).
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Mgrn1 | mahogunin, ring finger 1 |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | Igl-1 | immunoglobulin lambda chain, cluster 1 |
Marker Symbol | Marker Name | |
---|---|---|
Igl1-r | immunoglobulin lambda chain regulator |
Mice of this stock carry the “low” allele of the Igl1-r gene, which exhibit reduced levels of IGL1, along with the immunoglobulin lambda chain b variant allele (Igl-1b ) and mahoganoid (Mgrn1md).
Mahoganoid (Mgrn1md) arose spontaneously on strain C3H/HeJ at the Jackson Laboratory in 1957. The Igl-1b allele at the immunoglobulin lamba chain cluster 1 locus is found in strains SJL, YBR, BSVS and others and the Igl1-rlo allele occurs in strains SJL, BSVS and others. In 1972 Dr. M. C. Green received the fused phalanges (Fbn2fp) stock from Dr. Katrina Hummel. Fused phalanges arose spontaneously in strain C3HeB/FeHu. The stock Dr. Green received had been crossed once to C57BL/6J and it was then brother x sister bred to F20 in 1976. At F18 the stock was given to Dr. Muriel Davisson and it was continued to be inbred to F21 when a fused phalanges male was outcrossed to a homozygous mahoganoid (Mgrn1md) female. This mahoganoid female was the N2 offspring of a backcross that began with a mating of C57BL/6J x C3H/He-Mgrn1md/+ from which an F1 was bred back to a C3H/HeJ-Mgrn1md/Mgrn1md, which was at F69. The N2 homozygous female resulting from this breeding was bred with the F21 fused phalanges male and their offspring were bred brother x sister to F20. At that point, a mahoganoid male was outcrossed to an Lystbg homozygous female on a congenic SJL/J background at generation N12F4 from Dr. John Roths. The resulting stock was sibling mated and a homozygous mahoganoid female was backcrossed to an SJL/J male. The stock was then bred as homozygous for mahoganoid (Mgrn1md),Igl-1b and Igl1-rlo all on chromosome 16. It was cryopreserved in 1991 by mating homozygotes at F27 and F28.
Allele Name | mahoganoid |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | md |
Gene Symbol and Name | Mgrn1, mahogunin, ring finger 1 |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 16 |
General Note | The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791). |
Molecular Note | The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 16 |
When using the STOCK Mgrn1md Igl-1b Igl1-rlo/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001277 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Mgrn1<md>, Igl-1<b>, and Igl1-r<lo>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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