WB.Cg-Spta1^sph-2Bc/BrkJ

Stock number: 001184
Product name: spherocytosis 2 British Columbia

Allele

Symbol: Spta1^sph-2Bc
Name: spherocytosis 2 British Columbia
MGI accession ID: MGI:1856180
Generation method: Spontaneous
Marker symbol: Spta1
Marker name: spectrin alpha, erythrocytic 1
Chromosome: 1
Strain of origin: mixed
Molecular note: The mutation in the sph-BC mouse was identified as a G-to-T in transversion in the first nucleotide of intron 41. This mutation eliminates exon 41 splice donor site G-GT by changing it to G-TT. This causes a splicing defect that results in the skipping of exon 41 causing the deletion of 54 amino acids as well as a frameshift and a premature stop codon.
General note: This allele arose from a mixed SELH stock at the University of British Columbia in 1983.