Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Spta1 | spectrin alpha, erythrocytic 1 |
Allele Name | spherocytosis 2 British Columbia |
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Allele Type | Spontaneous |
Allele Synonym(s) | sph2Bc |
Gene Symbol and Name | Spta1, spectrin alpha, erythrocytic 1 |
Gene Synonym(s) | |
Strain of Origin | mixed |
Chromosome | 1 |
General Note | This allele arose from a mixed SELH stock at the University of British Columbia in 1983. |
Molecular Note | The mutation in the sph-BC mouse was identified as a G-to-T in transversion in the first nucleotide of intron 41. This mutation eliminates exon 41 splice donor site G-GT by changing it to G-TT. This causes a splicing defect that results in the skipping of exon 41 causing the deletion of 54 amino acids as well as a frameshift and a premature stop codon. |
When using the spherocytosis 2 British Columbia mouse strain in a publication, please cite the originating article(s) and include JAX stock #001184 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or wildtype for Spna1<sph-2Bc> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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