B6.AK-H2^k/FlaEgJ

Stock number: 001148
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

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The AKR/JBoy H2 complex (H2^k) on chromosome 17 was introgressed onto the C57BL/6JBoy background. Mice congenic for H2 haplotypes are widely used in immunologic research and often vary in immune response and pathogen susceptibility from the recipient strain.

Detailed description

In this congenic strain, the AKR/JBoy H2 complex (H2^k) on chromosome 17 was introgressed onto the C57BL/6JBoy background. H2^k occurs naturally in the following inbred strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, and ST/bJ. The H2^k haplotype is k at the class I loci (K, D) and the class II loci (A, E). Mice congenic for H2 haplotypes are widely used in immunologic research and often vary in immune response and pathogen susceptibility from the recipient strain.

Development

The AKR/JBoy H2 complex (H2^k) on chromosome 17 was introgressed onto the C57BL/6JBoy background for at 14 generations with selection for AKR-derived H2^k at each generation. The strain was generated and maintained by Boyd, and then transferred to Flaherty and then Egorov at The Jackson Laboratory.

Allele

Symbol: H2^k
Name: k variant
MGI accession ID: MGI:3579322
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: Not Applicable
Site of expression: Cell surface of almost all nucleated cells.
General note: The k variant has been observed in the following strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, ST/bJ, MRL/MpJ-Fas^lpr/J