Overview

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The AKR/JBoy H2 complex (H2^k) on chromosome 17 was introgressed onto the C57BL/6JBoy background. Mice congenic for H2 haplotypes are widely used in immunologic research and often vary in immune response and pathogen susceptibility from the recipient strain.

Genetic overview

Genetic Background	Generation

H2^k

Allele Type	Gene Symbol	Gene Name
Not Applicable	H2	histocompatibility-2, MHC

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Research Applications

Immunology, Inflammation and Autoimmunity Research

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Details

Detailed Description

In this congenic strain, the AKR/JBoy H2 complex (H2^k) on chromosome 17 was introgressed onto the C57BL/6JBoy background. H2^k occurs naturally in the following inbred strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, and ST/bJ. The H2^k haplotype is k at the class I loci (K, D) and the class II loci (A, E). Mice congenic for H2 haplotypes are widely used in immunologic research and often vary in immune response and pathogen susceptibility from the recipient strain.

Development

The AKR/JBoy H2 complex (H2^k) on chromosome 17 was introgressed onto the C57BL/6JBoy background for at 14 generations with selection for AKR-derived H2^k at each generation. The strain was generated and maintained by Boyd, and then transferred to Flaherty and then Egorov at The Jackson Laboratory.

Control Suggestions

Approximate Controls

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Genetics

H2^k

Allele Symbol: H2^k

Allele Name	k variant
Allele Type	Not Applicable
Allele Synonym(s)	H-2^k
Gene Symbol and Name	H2, histocompatibility-2, MHC
Gene Synonym(s)
Site of Expression	Cell surface of almost all nucleated cells.
Strain of Origin	Not Applicable
Chromosome	17
General Note	The k variant has been observed in the following strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, ST/bJ, MRL/MpJ-Fas^lpr/J

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: H2^k related

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers

Mammalian Phenotype Terms by Genotype

References

Additional - H2^k related

Technical Support

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Genotyping Protocols
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Appearance
- black
  Related Genotype: a/a
Citation
When using the B6.AK-H2^k/FlaEgJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001148 in your Materials and Methods section.

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Genetic overview

Research Applications

Detailed Description

Development

Control Suggestions

Approximate Controls

Additional Information

H2k

Allele Symbol: H2k

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: H2k related

Mammalian Phenotype Terms by Genotype

References

Additional - H2k related

Genotyping Protocols

Appearance

Citation

Strain Interest Registration

Contact Information

Interest

Terms Of Use

Licensing Information

H2^k

Allele Symbol: H2^k

Genotype: H2^k related

Additional - H2^k related