C.BKa-Igh b/IcrSmn mice express the immunoglobulin heavy-chain repertoire (Ighb) of C57BL/Ka. This is a congenic strain arising from a backcross of BALB/cxC57BL/Ka-Igh a/Igh b to BALB/c from which progeny were intercrossed to obtain mice homozygous for Igh b. Initial reports indicated that these mice occasionally expressed IgG2a, but this phenomenon was transient and unpredictable. The C.BKa-Igh b/IcrSmn (commonly referred to as C.B-17) is the background strain in which the Prkdc scid mutation arose. It is primarily used as a coisogenic control strain for C.B17/Icr-scid. Characteristics of C.BKa-Igh b/IcrSmn are essentially those of BALB/c.
This is a congenic strain carrying a varient of the immunoglobulin heavy chain complex allele from the C57BL/Ka strain. The BALB/c-Ighb/Smn strain (commonly referred to as C.B-17) is the background strain in which the Prkdcscid mutation arose.
When using the C.BKa-Ighb/IcrSmnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001107 in your Materials and Methods section.