STOCK T(3;4)5Rk Tyrp1^b/J

Stock number: 001101
Product name: T5Rk
Research areas: Dermatology Research, Mouse/Human Gene Homologs, Research Tools

Allele

Symbol: Tyrp1^b
Name: brown
MGI accession ID: MGI:1855960
Generation method: Spontaneous
Synonyms: b
Marker symbol: Tyrp1
Marker name: tyrosinase-related protein 1
Marker synonyms: b-PROTEIN; CAS2; CATB; GP75; isa; OCA3; TRP; TRP1; TRP-1; TYRP
Chromosome: 4
Strain of origin: old mutant of the mouse fancy
Molecular note: A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation changes cysteine to tyrosine at position 110 (p.C110Y) in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype.

Allele

MGI accession ID: MGI:103760
Marker symbol: T(3;4)5Rk
Marker name: reciprocal translocation, Chr 3 and 4, Roderick 5
Marker synonyms: T5Rk
Chromosome: 4