Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Tyrp1 | tyrosinase-related protein 1 |
Marker Symbol | Marker Name | |
---|---|---|
T(3;4)5Rk | reciprocal translocation, Chr 3 and 4, Roderick 5 |
Allele Name | brown |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | b |
Gene Symbol and Name | Tyrp1, tyrosinase-related protein 1 |
Gene Synonym(s) | |
Strain of Origin | old mutant of the mouse fancy |
Chromosome | 4 |
Molecular Note | A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation changes cysteine to tyrosine at position 110 (p.C110Y) in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 4 |
When using the STOCK T(3;4)5Rk Tyrp1b/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001101 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for T(3;4)5Rk , 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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