Overview

This is one of 20 cryopreserved recombinant inbred (RI) strains of mice derived from the progenitor strains AKR/J and DBA/2J.

The strain distribution pattern (SDP) for RI strains is available through the Mouse Genome Informatics Contributed Data Sets

Genetic overview

Genetic Background	Generation

Tyr^c

Allele Type	Gene Symbol	Gene Name
Spontaneous	Tyr	tyrosinase

Myo5a^d

Allele Type	Gene Symbol	Gene Name
Spontaneous	Myo5a	myosin VA

Emv3^a

Allele Type	Gene Symbol	Gene Name
Not Applicable	Emv3	endogenous ecotropic MuLV 3

Rmcf^r

Allele Type	Gene Symbol	Gene Name
Spontaneous	Rmcf	resistance to MCF virus

Marker(s)

	Marker Symbol	Marker Name
	Emv14	endogenous ecotropic MuLV 14
	Emv11	endogenous ecotropic MuLV 11

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Research Applications

Research Tools
Dermatology Research
Mouse/Human Gene Homologs

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Detailed Description

This is one of 20 cryopreserved recombinant inbred (RI) strains of mice derived from the progenitor strains AKR/J and DBA/2J.

The strain distribution pattern (SDP) for RI strains is available through the Mouse Genome Informatics Contributed Data Sets

Selected References

Mucenski ML; Taylor BA; Jenkins NA; Copeland NG. 1986. AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. Mol Cell Biol 6(12):4236-43PubMed: 3025647 MGI: J:20300

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Genetics

Tyr^c

Allele Symbol: Tyr^c

Allele Name	albino
Allele Type	Spontaneous
Allele Synonym(s)	c
Gene Symbol and Name	Tyr, tyrosinase
Gene Synonym(s)
Site of Expression	Melanocytes.
Strain of Origin	old mutant of the mouse fancy
Chromosome	7
General Note	Tyr^c, albino. This very old mutant was already known in Greek and Roman times. Hair and eyes are completely devoid of pigment (J:5436, J:5001, J:30725). The albino mutation affects the amount of tyrosinase, and thus of melanin, in pigment cells, but does not interfere with the production of pigment cells themselves (J:12173, J:13092). Melanocytes with melanosomes showing normal fine structure occur in the retina and hair follicles. Pigment granules are smaller and fewer than normal and completely lack melanin (J:5346, J:5001, J:30725). Tyrosinase is almost absent (J:12173).Although Tyr is the structural gene for tyrosinase, some albino mutations may affect tyrosinase enzyme regulation rather than structure (J:6611), suggesting that these mutations affect tyrosinase inhibition (J:5346), presumably via control regions of the gene. All the mutant alleles are recessive to wild-type in phenotype, but heterozygotes with wild-type produce intermediate amounts of tyrosinase (J:12173).Albino-locus mutants with lightly pigmented eyes have a reduced number of fibers of the optic nerve going to the ipsilateral lateral geniculate nucleus of the brain. This is probably a secondary effect of reduced tyrosinase activity or amount of pigment in the pigment epithelium, since genes at other loci that reduce eye pigmentation also cause the same anomaly (J:5436, J:6064).Abnormal retinal pathways disrupted at the optic chiasm that occur in albinism can be corrected with a Tyr normal transgene (J:22320).Lipofuscin is a terminal oxidation product pigment that accumulates with age. In a cross of C57BL/6J and BALB/cJ, which differ in cardiac deposition of the pigment, this trait segregated with albinism, and is controlled by the Tyr locus (J:15460).Tyrc homozygotes do not perform as well as normal in a number of behavioral tests. It is likely that this effect is mediated, at least in part, by defective vision resulting from lack of retinal pigment (J:5470, J:5360, J:5378).
Molecular Note	The specific mutation in the albino allele is a G-to-C transversion causing an amino acid change from cysteine to serine at position 103 or 85 (p.C103S for pre-protein, p.C85S for mature protein). This mutation introduces a DdeI enzyme restriction site.

Myo5a^d

Allele Symbol: Myo5a^d

Allele Name	dilute
Allele Type	Spontaneous
Allele Synonym(s)	blue dilution; d; d^v; Maltese dilution
Gene Symbol and Name	Myo5a, myosin VA
Gene Synonym(s)
Strain of Origin	old mutant of the mouse fancy
Chromosome	9
Molecular Note	This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5a^d gene. Reversions of Myo5a^d to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.

Emv3^a

Allele Symbol: Emv3^a

Allele Name	endogenous ecotropic MuLV 3, present
Allele Type	Not Applicable
Allele Synonym(s)
Gene Symbol and Name	Emv3, endogenous ecotropic MuLV 3
Gene Synonym(s)
Strain of Origin	Not Applicable
Chromosome	9
General Note	The provirus is present in the following strains: BDP/J, DBA/1J, DBA/2DeJ, DBA/2J, HRS/J, I/LnJ, P/J, and SEA/GnJ.

Rmcf^r

Allele Symbol: Rmcf^r

Allele Name	MCF resistant
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Rmcf, resistance to MCF virus
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcf^r determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcf^s determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1, a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcf^r protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxv^s/Sxv^r mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcf^r increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcf^r allele contains an endogenous MCF gp70 env gene and that the Rmcf^s allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note	This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The dominant r (resistance) allele is found in strains DBA/1, DBA/2 and CBA/Ca.

Emv14

Marker Symbol: Emv14

Marker Synonym(s)
Chromosome(s)	11

Emv11

Marker Symbol: Emv11

Marker Synonym(s)
Chromosome(s)	7

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Research Tools
- Genetics Research
  - Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
  - Gene Mapping
- Cancer Research
  - genes regulating lymphoma development

Genotype: Myo5a^d related

Dermatology Research
- Color and White Spotting Defects
Mouse/Human Gene Homologs
- Griscelli Syndrome

Genotype: Tyr^c related

Dermatology Research
- Color and White Spotting Defects
  - oculocutaneous albinism, type I
Mouse/Human Gene Homologs
- albinism, tyrosine negative

Mammalian Phenotype Terms by Genotype

Phenotype Information

Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for AKXD RI Line

References

Mucenski ML; Taylor BA; Jenkins NA; Copeland NG. 1986. AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. Mol Cell Biol 6(12):4236-43PubMed: 3025647 MGI: J:20300

Additional References

Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1981. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature 293(5831):370-4PubMed: 6268990 MGI: J:6587

Additional - Emv11 related

Additional - Emv14 related

Additional - Emv3^a related

Additional - Myo5a^d related

Additional - Rmcf^r related

Additional - Tyr^c related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Appearance
- albino
  Related Genotype: Tyr^c/Tyr^c
Citation
When using the AKXD18/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001093 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Inbred, 1 pair minimum will be supplied

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Genetic overview

Marker(s)

Research Applications

Base Price

Detailed Description

Selected References

Tyrc

Allele Symbol: Tyrc

Myo5ad

Allele Symbol: Myo5ad

Emv3a

Allele Symbol: Emv3a

Rmcfr

Allele Symbol: Rmcfr

Emv14

Marker Symbol: Emv14

Emv11

Marker Symbol: Emv11

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Myo5ad related

Genotype: Tyrc related

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Additional References

Additional - Emv11 related

Additional - Emv14 related

Additional - Emv3a related

Additional - Myo5ad related

Additional - Rmcfr related

Additional - Tyrc related

Genotyping Protocols

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

Tyr^c

Allele Symbol: Tyr^c

Myo5a^d

Allele Symbol: Myo5a^d

Emv3^a

Allele Symbol: Emv3^a

Rmcf^r

Allele Symbol: Rmcf^r

Genotype: Myo5a^d related

Genotype: Tyr^c related

Additional - Emv3^a related

Additional - Myo5a^d related

Additional - Rmcf^r related

Additional - Tyr^c related