The B10.RIII(71NS)/SnJ congenic strain develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP). Susceptibility is associated with the major histocompatibility complex (MHC)(V beta 8<+>, H2<r>) and other non MHC loci. This strain is also susceptible to induction of collagen-induced arthritis.
Dr. Larry Mobraaten of The Jackson Laboratory backcrossed Dr. Snell's B10.RIII-H2r H2-T18b/(71NS)Sn (stock# 000457) to C57BL/10Sn for 10 additional generations and then fixed the congenic interval to homozygosity. In 1994 embryos were generated for cryopreservation by homozygous intercross.
When using the B10.RIII-H2r/(71NS)nMobJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001069 in your Materials and Methods section.