B6.PL-Cd8a^a Cd8b1^a/(85NS)CyJ

Stock number: 001065
Product name: B6.PL (85NS)/Cy

Detailed description

This congenic strain carries the T-cell Cd8a^a and Cd8b1^a co-receptor alleles from the PL/J strain on a C57BL/6J genetic background.

Development

Ly-2 is now known as Cd8a. The Cd8a^a allele is found in PL, C3H/An, DBA/2, C58, and other strains. Ly-3 is now known as Cd8b1. The Cd8b1^a allele is found in strains PL, C58, AKR, PL, and RF. Cd8a^a and Cd8b1^a are closely linked on chromosome 6 and were backcrossed from PL/J onto C57BL/6J. At the 26th or 27th backcross generation the PL/J allele of Igk-V28, formerly Igk-Ef1, recombined out, resulting in this strain, which carries the following alleles: Cd8a^a Cd8b1^a Igk-V28^b. This strain was cryopreserved at generation N30F28. (Gibson et al., 1978; Gibson et al., 1983.)

Allele

MGI accession ID: MGI:88346
Marker symbol: Cd8a
Marker name: CD8 antigen, alpha chain
Marker synonyms: CD8; CD8alpha; IMD116; Leu2; Ly-2; Ly-35; Ly-B; Lyt-2; p32
Chromosome: 6

Allele

MGI accession ID: MGI:88347
Marker symbol: Cd8b1
Marker name: CD8 antigen, beta chain 1
Marker synonyms: CD8B1; CD8beta; CD8BP; LEU2; LY3; Ly-3; Ly-C; LYT3; Lyt-3; P37
Chromosome: 6