This congenic strain carries the T-cell Cd8aa and Cd8b1a co-receptor alleles from the PL/J strain on a C57BL/6J genetic background.
Genetic Background | Generation |
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000664 C57BL/6J |
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Marker Symbol | Marker Name | |
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Cd8b1 | CD8 antigen, beta chain 1 | |
Cd8a | CD8 antigen, alpha chain |
This congenic strain carries the T-cell Cd8aa and Cd8b1a co-receptor alleles from the PL/J strain on a C57BL/6J genetic background.
Ly-2 is now known as Cd8a. The Cd8aa allele is found in PL, C3H/An, DBA/2, C58, and other strains. Ly-3 is now known as Cd8b1. The Cd8b1a allele is found in strains PL, C58, AKR, PL, and RF. Cd8aa and Cd8b1a are closely linked on chromosome 6 and were backcrossed from PL/J onto C57BL/6J. At the 26th or 27th backcross generation the PL/J allele of Igk-V28, formerly Igk-Ef1, recombined out, resulting in this strain, which carries the following alleles: Cd8aa Cd8b1a Igk-V28b. This strain was cryopreserved at generation N30F28. (Gibson et al., 1978; Gibson et al., 1983.)
When using the B6.PL-Cd8aa Cd8b1a/(85NS)CyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001065 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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