B6.Cg-Del(17)T^Orl/EiJ

Stock number: 001054
Product name: T-Orleans

Detailed description

These mice carry a spontaneous deletion that includes T through, at least, Qk. The allele expresses the t- haplotype specific proteins p63/6.9a, TCP-4B, TCP-5, TCP-9, and TCP-8B.

Development

The T^Orl mutation arose spontaneously in approximately 1972 in the Swiss/Orl non-inbred stock. It was backcrossed several generations onto C57BL/6JOrl and imported into the laboratory of Dr. Eva Eicher at The Jackson Laboratory where it was backcrossed onto the C57BL/6J background. In 1987 C57BL/6J females were bred with heterozygous males at generation N15 to generate embryos for cryopreservation.

Allele

Symbol: Del(17)T^Orl
Name: deletion, Chr 17, T, T-Orleans
MGI accession ID: MGI:1856189
Generation method: Spontaneous
Synonyms: T^Orl; Tt^Orl
Marker symbol: Del(17)T^Orl
Marker name: deletion, Chr 17, T, T-Orleans
Chromosome: 17
Strain of origin: Orl:Swiss
Molecular note: The deletion comprising this allele includes T through, at least, Qk as all short-tailed mice from matings of T^Orl/+ males to Qk^qk/Qk^qk females have a "quaking" phenotype. In addition this allele expresses the t- haplotype specific proteins p63/6.9a, TCP-4B, TCP-5, TCP-9, and TCP-8B.