B6.L-Tbx6^rv/J

Stock number: 001052
Product name: rib-vertebrae
Research areas: Developmental Biology Research

Detailed description

These mice carry a spontaneous, hypomorphic mutation at the Tbx6 locus characterized by fusions of lower ribs and malformations of vertebrae.

Allele

Symbol: Tbx6^rv
Name: rib-vertebrae
MGI accession ID: MGI:1857025
Generation method: Spontaneous
Attributes: Hypomorph
Synonyms: rv
Marker symbol: Tbx6
Marker name: T-box 6
Marker synonyms: SCDO5
Chromosome: 7
Strain of origin: C57L/J
Molecular note: This hypomorphic allele contains a rearrangement in the promoter region. A 182 bp insertion 240 bp upstream of the translation initiation site includes part of exon 1, intron 1, and a portion of exon 2 in inverted orientation. Whole mount in situ hybridisation detected variable and less abundant transcript expression in homozygous mutant E9.5 embryos.