Overview

Also Known As:meander tail 2 Jackson

These mice carry a spontaneous remutation at the mea locus characterized by variably shortened and kinked tails. The strain is maintained in linkage with the misty coat color mutation (Dock7^m).

Genetic overview

Genetic Background	Generation

mea^2J

Allele Type	Gene Symbol	Gene Name
Spontaneous	mea	meander tail

Allele Type	Gene Symbol	Gene Name
Spontaneous	Dock7	dedicator of cytokinesis 7

Research Applications

Dermatology Research
Developmental Biology Research
Neurobiology Research

View All Research Applications

Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Detailed Description

Mice homozygous for the meander tail 2J spontaneous mutation (mea^2J) have a phenotype that is very similar to the original meander tail (mea) and meander tail J mice (mea^J). Homozygous mutant mice have variably shortened and kinked tails. At about 2 weeks an unsteadiness of gait, often amounting to a tremor, appears. Homozygotes are smaller and less vigorous than wiltype controls but are fertile. The anterior lobe of the cerebellum is disorganized. Purkinje cells are scattered, some cellular layers never form, and Bergmann glial processes are absent. The cytoarchitecture of the posterior lobe is normal, and the transition from normal to disorganized areas is sharply demarcated. This strain is maintained in linkage with the misty coat color mutation (Dock7^m).

Control Suggestions

Heterozygote from the colony
000662 C57BLKS/J

Additional Information

Considerations for Choosing Controls

Genetics

mea^2J

Allele Symbol: mea^2J

Allele Name	meander tail 2 Jackson
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	mea, meander tail
Gene Synonym(s)
Strain of Origin	BKS.Cg-Dock7^m +/+ Lepr^db
Chromosome	4
Molecular Note	This allele was identified from the results of a noncomplementation test with mea^J. The molecular lesion is unknown.

Dock7^m

Allele Symbol: Dock7^m

Allele Name	misty
Allele Type	Spontaneous
Allele Synonym(s)	m
Gene Symbol and Name	Dock7, dedicator of cytokinesis 7
Gene Synonym(s)
Strain of Origin	DBA/J
Chromosome	4
Molecular Note	Crosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7^mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Dock7^m related

Dermatology Research
- Color and White Spotting Defects

Genotype: mea^2J related

Developmental Biology Research
- Skeletal Defects
Neurobiology Research
- Ataxia (Movement) Defects
- Cerebellar Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: mea^2J/mea^2J
involves: C57BLKS/J

behavior/neurological phenotype

abnormal gait

limbs/digits/tail phenotype

kinked tail

short tail

References

Additional References

Hamre KM; Goldowitz D. 1996. Analysis of gene action in the meander tail mutant mouse: examination of cerebellar phenotype and mitotic activity of granule cell neuroblasts. J Comp Neurol 368(2):304-15PubMed: 8725309 MGI: J:32737

Additional - Dock7^m related

Additional - mea^2J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

mea and Dock7^m are closely linked on chromosome 4. This strain is maintained with mea^2J in coupling with Dock7^m. The mutant is small and prone to malocclusion. Wait until 4+ weeks to wean mutants.
- Additional Breeding and Husbandry Support
Citation
When using the meander tail 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #001049 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous for mea<2J>, Heterozygous for db<+>, Heterozygous for m

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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Also Known As:meander tail 2 Jackson

Genetic overview

Research Applications

Base Price

Detailed Description

Control Suggestions

Additional Information

mea2J

Allele Symbol: mea2J

Dock7m

Allele Symbol: Dock7m

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Dock7m related

Genotype: mea2J related

Mammalian Phenotype Terms by Genotype

Genotype: mea2J/mea2Jinvolves: C57BLKS/J

behavior/neurological phenotype

limbs/digits/tail phenotype

References

Additional References

Additional - Dock7m related

Additional - mea2J related

Genotyping Protocols

Breeding Considerations

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

mea^2J

Allele Symbol: mea^2J

Dock7^m

Allele Symbol: Dock7^m

Genotype: Dock7^m related

Genotype: mea^2J related

Genotype: mea^2J/mea^2J
involves: C57BLKS/J

Additional - Dock7^m related

Additional - mea^2J related