These mice carry a spontaneous mutation at the Grid2 locus characterized by a swaying of the hindquarters and a jerky up and down movement. The mutation induces apoptotic programmed death of the cerebellar cortical Purkinje cells.Read More +
Mice heterozygous for the lurcher spontaneous mutation (GridLc) show a characteristic swaying of the hindquarters and a jerky up and down movement. They are identifiable with sureness by their behavior at 12 to 14 days of age. Homozygous mutant micedie shortly after birth but have no visible abnormalities and show severe postnatal loss of Purkinje cells and granule cells. Virtually no Purkinje cells are found in adults and granule cells are reduced to about 10% of normal. The number of neurons in the inferior olivary nucleus falls to about 25% of normal. Other cell populations are normal. The Lc mutation induces apoptotic programmed death of the cerebellar cortical Purkinje cells. Homozygous mutant mice are reproducibly deficient in defined cell populations and thus have been used to study cerebellar function and the distribution of various brain components on cerebellar cells.
|Allele Synonym(s)||GluD2LC; Grid2-Lc; lc|
|Gene Symbol and Name||Grid2, glutamate receptor, ionotropic, delta 2|
|Strain of Origin||STOCK MitfMi-wh|
|Molecular Note||This allele comprises a nucleotide substitution that causes a change in an amino acid in the third transmembrane domain of Grid2.|
When using the lurcher mouse strain in a publication, please cite the originating article(s) and include JAX stock #001046 in your Materials and Methods section.
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