BALB/cByJ

Stock No:: 001026

Also Known As: CByJ, BALB Bailey, BALB/c Bailey J, CBy

Mice of this substrain of BALB/c, among other differences, have better reproductive performance and less aggression than mice of the BALB/cJ substrain (Stock No. 000651).

Genetic overview

Genetic Background	Generation
	Contact Technical Support (2018-07-27 00:00:00)

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Research Applications

Neurobiology Research
Sensorineural Research
Cancer Research
Immunology, Inflammation and Autoimmunity Research
Research Tools

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Base Price

Starting at:

$31.48 Domestic price for female 3-week

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Details

Important Note

This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.

Detailed Description

BALB/c mice are particularly well known for the production of plasmacytoma on injection with mineral oil, forming the basis for the production of monoclonal antibodies. Although not all BALB/c substrains have been examined for plasmacytoma induction, substrains derived from the Andervont (An) lineage (which includes BALB/cByJ) typically are susceptible, while those descended from BALB/cJ are resistant. Mammary tumor incidence is normally low, but infection with mammary tumor virus by fostering to MMTV⁺ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life, including reticular neoplasm, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains. A deficiency of Acads (acyl-Coenzyme A dehydrogenase, short chain) leads to severe organic aciduria. BALB/cByJ develop a fatty liver upon fasting or dietary fat challenge and become hypoglycemic after an 18-hour fast. BALB/cByJ mice have the advantage of better reproductive performance and less aggression than mice of the BALB/cJ substrain.

Development

This is a substrain of BALB (Bagg’s albino) derived initially from the BALB strain maintained by MacDowell at Cold Spring Harbor, eventually sent to Andervont as BALB/cAn and to NIH where D.W. Bailey obtained the substrain and maintained it through locations at the University of California Medical School at San Francisco and ultimately at The Jackson Laboratory. In 1975 at generation F136 BALB/cBy (Stock No. 000650) mice were sent to JAX production facility upon hysterectomy derivation and became the BALB/cByJ substrain.

The Andervont/Bailey lineage and the lineage giving rise to BALB/cJ were separated from the BALB/c line maintained by Snell at The Jackson Laboratory during the period of 1937 to 1939 around generation F36.

Selected References

Hinsdale ME; Kelly CL; Wood PA. 1993. Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA. (3): 605-11. PubMed: 8325633 MGI: 12730
Wood PA; Hinsdale ME; Kelly CL. 1993. Molecular detection of the Bcd-1 null allele in BALB/cByJ mice by polymerase chain reaction: a simple assay for genetic monitoring (2): 342-44. MGI: 12766
Wood PA; Amendt BA; Rhead WJ; Millington DS; Inoue F; Armstrong D. 1989. Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. (1): 38-43. PubMed: 2919115 MGI: 14636
Ebbesen P. 1971. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. (6): 1241-5. PubMed: 4941118 MGI: 24391
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. (1): 141-8. PubMed: 4322934 MGI: 24766
Bentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. (1): 377-84. PubMed: 4318784 MGI: 24884
Sundberg JP; Hanson CA; Roop DR; Brown KS; Bedigian HG. 1991. Myoepitheliomas in inbred laboratory mice. (4): 313-23. PubMed: 1719689 MGI: 22876
Smith Richards BK; Belton BN; York B; Volaufova J. 2004. Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat. (2): R311-9. PubMed: 14592933 MGI: 88762
Champy MF; Selloum M; Zeitler V; Caradec C; Jung B; Rousseau S; Pouilly L; Sorg T; Auwerx J. 2008. Genetic background determines metabolic phenotypes in the mouse. (5): 318-31. PubMed: 18392653 MGI: 138762
Roderick TH; Langley SH; Leiter EH. 1985. Some unusual genetic characteristics of BALB/c and evidence for genetic variation among BALB/c substrains. 9-18. PubMed: 3899524 MGI: 24401
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. (5): 902-11. PubMed: 15081119 MGI: 90283

View All References

Genetics

Hld

Allele Symbol: Hld

Allele Name	hippocampal lamination defect
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Hld, hippocampal lamination defect
Gene Synonym(s)
Strain of Origin	BALB/cJ
Chromosome	UN

Ahr^b-2

Allele Symbol: Ahr^b-2

Allele Name	b-2 variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^b-2; Ah^h
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	bHLHe76; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; Ahh; dioxin receptor; In; Ah; Ahre; inflammatory reactivity
Strain of Origin	BALB/cBy
Chromosome	12
General Note	C57BL/6 carries the responsive Ahr^b allele; DBA/2 carries nonresponsive Ahr^d. Heterozygotes (Ahr^b/Ahr^d) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahr^b-1; Ahr^b-2 is carried by BALB/cBy, A, and C3H; and Ahr^b-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahr^b-1 and Ahr^d have been determined (J:17460). Strain of origin - this allele was found in BALB/cByJ, A/J, C3H/HeJ, CBA strains
Molecular Note	This allele encodes a high affinity, heat labile, 104 kDa receptor containing 848 amino acids. Sequencing studies of cDNA from C57BL/6J congenic mice homozygous for this allele identified nucleotide substitutions in the ORF that would cause 5 amino acid differences between the C57BL/6J and BALB/cBy peptides, and 2 amino acid differences between the BALB/cBy and DBA/2J peptides. A T to C transition in exon 11 replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the BALB/cBy allele. This change would extend translation of the BALB/cBy mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa, vs 95 kDa for the C57BL/6J allele).

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	Cdh23^753A; mdfw
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	bob; bustling; bobby; nmf112; nmf252; nmf252; 4930542A03Rik; ahl; 4930542A03Rik; W; sals; mdfw; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; modifier of deaf waddler; age related hearing loss 1; v; USH1D; nmf181; RIKEN cDNA 4930542A03 gene; CDHR23; sals; waltzer; nmf112; nmf181; mdfw; neuroscience mutagenesis facility, 112; bus; ahl; bob; salsa; PITA5
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Acads^del-J

Allele Symbol: Acads^del-J

Allele Name	deletion, Jackson
Allele Type	Spontaneous
Allele Synonym(s)	Bcd-1^c; Scad
Gene Symbol and Name	Acads, acyl-Coenzyme A dehydrogenase, short chain
Gene Synonym(s)	Hdlq8; AI196007; Bcd-1; Bcd1; butyryl CoA dehydrogenase 1; ACAD3; expressed sequence AI196007; HDL QTL 8; Hdlq8; SCAD; Bcd-1; Bcd1; Scad
Strain of Origin	BALB/cByJ
Chromosome	5
Molecular Note	A 278bp deletion occurs which starts in intron "A" and includes exon "B" and the first 78bp of exon "C". As a result of this deletion, mRNA transcription is reduced to about 35% of normal and includes two forms, a longer normal length transcript and a shorter misspliced form. If these mRNAs were translated they both would result in truncated products. Protein product is undetectable immunologically and there is a total absence of enzyme activity.

Mdmg1

Marker Symbol: Mdmg1

Marker Synonym(s)
Chromosome(s)	17

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Cancer Research
- Increased Tumor Incidence
  - Mammary Gland Tumors
  - Mammary Gland Tumors: late onset
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimental allergic encephalomyelitis (EAE)
Neurobiology Research
- Neurodevelopmental Defects
  - callosal agenesis, incomplete penetrance
- Hearing Defects
  - Age related hearing loss
Research Tools
- General Purpose
- Cancer Research
  - monoclonal antibodies, myeloma and hybridoma production
- Immunology, Inflammation and Autoimmunity Research
  - background strain for histocompatibility congenics
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Mammalian Phenotype Terms by Genotype

Genotype: Acads^del-J/Acads^del-J
BALB/cByJ

nervous system phenotype

decreased circulating glycine level
- serum glycine concentrations are markedly lower than in controls

behavior/neurological phenotype

abnormal food preference
- given a choice, selection of a fat/protein diet declines with time

abnormal liquid preference
- did not develop a preference for drinking water containing a corn oil emulsion

homeostasis/metabolism phenotype

abnormal adaptive thermogenesis
- body temperature in most BALB/cByJ mice dropped 10 degrees C in less than 4 h at 4 degrees C, with none able to maintain body temperature for longer than 8 h in the cold

abnormal fatty acid oxidation
- block in short-chain fatty acid oxidation shown by reduced butyryl-CoA dehydrogenation in liver mitochondria

decreased circulating carnitine level
- slightly lower plasma carnitine level

decreased circulating glycine level
- serum glycine concentrations are markedly lower than in controls

ethylmalonic aciduria
- ethylmalonate urinary excretion is higher than in controls
- markedly increased urinary concentrations of ethylmalonic acid in nonfasting and fasting mice
- relatively large amounts of ethylmalonate in the urine at 7-14 weeks of age

hypoglycemia
- hypoglycemia develops after 18 hours of fasting with mean serum glucose measuring less than half of control values

increased circulating HDL cholesterol level
- HDL levels were significantly increased in mutant mice for both males and females fed either a regular chow or a high-fat diet

organic aciduria
- ethylmalonate, methylsuccinate, and butyrylglycine urinary excretion is higher than in controls
- markedly increased urinary concentrations of ethylmalonic and methylsuccinic acids, and N-butyrylglycine in nonfasting and fasting mice, and remained elevated with or without medium chain triglyceride challenge
- organic aciduria at 7-14 weeks of age, caused by relatively large amounts of n-butyrylglycine and ethylmalonate in the urine
- upon dosing with carnitine, mice excrete large amounts of butyryl-carnitine in the urine

liver/biliary system phenotype

hepatic steatosis
- fat deposits accumulate in the liver after 18 hours of fasting or with dietary fat challenge

renal/urinary system phenotype

ethylmalonic aciduria
- ethylmalonate urinary excretion is higher than in controls
- markedly increased urinary concentrations of ethylmalonic acid in nonfasting and fasting mice
- relatively large amounts of ethylmalonate in the urine at 7-14 weeks of age

organic aciduria
- ethylmalonate, methylsuccinate, and butyrylglycine urinary excretion is higher than in controls
- markedly increased urinary concentrations of ethylmalonic and methylsuccinic acids, and N-butyrylglycine in nonfasting and fasting mice, and remained elevated with or without medium chain triglyceride challenge
- organic aciduria at 7-14 weeks of age, caused by relatively large amounts of n-butyrylglycine and ethylmalonate in the urine
- upon dosing with carnitine, mice excrete large amounts of butyryl-carnitine in the urine

cellular phenotype

abnormal fatty acid oxidation
- block in short-chain fatty acid oxidation shown by reduced butyryl-CoA dehydrogenation in liver mitochondria

muscle phenotype

abnormal skeletal muscle morphology
- wehn dosed with carnitine, mutant muscle exhibits a 9-fold increase in butyryl-carnitine concentration compared to controls

Genotype: Hld/Hld
either: BALB/cByJ or BALB/cJ

nervous system phenotype

abnormal dendrite morphology
- abnormally positioned by being late-generated
- cell bodies are located below the intrapyramidal mossy fiber layer

abnormal hippocampal mossy fiber morphology

abnormal hippocampus CA3 region morphology
- there is abnormal lamination of this cell layer resulting in superficial early generated neurons and deep late-generated neurons

abnormal hippocampus layer morphology
- Background Sensitivity - the anomaly is also seen in BALB/cByJ, F1 mice involving BALB sublines noted, and some CXB RI lines; C57BL/6J is considered wild-type for this feature
- this is secondary to a defect in neuronal migration

abnormal hippocampus morphology

abnormal neuronal migration

ectopic hippocampus pyramidal cells
- located below the intrapyramidal layer; some of the ectopic cells have short, fine-caliber dendritic branches arising near the points of contact of the intrapyramidal mossy fibers

cellular phenotype

abnormal neuronal migration

Phenotype Information

Body Weight Information - JAX^® Mice Strain BALB/cByJ (001026)

References

Hinsdale ME; Kelly CL; Wood PA. 1993. Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA. (3): 605-11. PubMed: 8325633 MGI: 12730
Wood PA; Hinsdale ME; Kelly CL. 1993. Molecular detection of the Bcd-1 null allele in BALB/cByJ mice by polymerase chain reaction: a simple assay for genetic monitoring (2): 342-44. MGI: 12766
Wood PA; Amendt BA; Rhead WJ; Millington DS; Inoue F; Armstrong D. 1989. Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. (1): 38-43. PubMed: 2919115 MGI: 14636
Ebbesen P. 1971. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. (6): 1241-5. PubMed: 4941118 MGI: 24391
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. (1): 141-8. PubMed: 4322934 MGI: 24766
Bentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. (1): 377-84. PubMed: 4318784 MGI: 24884
Sundberg JP; Hanson CA; Roop DR; Brown KS; Bedigian HG. 1991. Myoepitheliomas in inbred laboratory mice. (4): 313-23. PubMed: 1719689 MGI: 22876
Smith Richards BK; Belton BN; York B; Volaufova J. 2004. Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat. (2): R311-9. PubMed: 14592933 MGI: 88762
Champy MF; Selloum M; Zeitler V; Caradec C; Jung B; Rousseau S; Pouilly L; Sorg T; Auwerx J. 2008. Genetic background determines metabolic phenotypes in the mouse. (5): 318-31. PubMed: 18392653 MGI: 138762
Roderick TH; Langley SH; Leiter EH. 1985. Some unusual genetic characteristics of BALB/c and evidence for genetic variation among BALB/c substrains. 9-18. PubMed: 3899524 MGI: 24401
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. (5): 902-11. PubMed: 15081119 MGI: 90283

Additional References

Sass B; Peters RL; Kelloff GJ. 1976. Differences in tumor incidence in two substrains of Claude BALB/c (BALB/cfCd) mice, emphasizing renal, mammary, pancreatic, and synovial tumors. (5): 736-41. PubMed: 185454 MGI: 24797
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. (1): 4-20. PubMed: 16971002 MGI: 139775
Flaherty L; DiBiase K; Lynes MA; Seidman JG; Weinberger O; Rinchik EM. 1985. Characterization of a Q subregion gene in the murine major histocompatibility complex. (5): 1503-7. PubMed: 2983348 MGI: 7751
Bouwknecht JA; Paylor R. 2002. Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains. (2): 489-501. PubMed: 12429412 MGI: 81358
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. (4): R797-805. PubMed: 10749765 MGI: 62545
Southwick CH; Clark LH. 1966. Agressive behavior and exploratory activity in fourteen mouse strains 559. MGI: 23422
Teuscher C; Blankenhorn EP; Hickey WF. 1987. Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains. (2): 294-304. PubMed: 2446778 MGI: 150749
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice (8): 602-13. PubMed: 14945054 MGI: 167384
Depis F; Kwon HK; Mathis D; Benoist C. 2016. Unstable FoxP3+ T regulatory cells in NZW mice. (5): 1345-50. PubMed: 26768846 MGI: 228998
Sittig LJ; Jeong C; Tixier E; Davis J; Barrios-Camacho CM; Palmer AA. 2014. Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ. (11-12): 564-72. PubMed: 24997021 MGI: 265509

Additional - Acads^del-J

Qureshi IA; Leblanc D; Cyr D; Giguere R; Mitchell G. 1993. Breeding experiments to combine the X-linked sparse-fur (spf) mutation with the autosomal recessive BALB/cByJ strain: testing the biochemical phenotype of double-mutant mice as a model for ammonia: fatty acyl CoA synergism. (2): 744-9. PubMed: 8461026 MGI: 4161
Schiffer SP; Prochazka M; Jezyk PF; Roderick TH; Yudkoff M; Patterson DF. 1989. Organic aciduria and butyryl CoA dehydrogenase deficiency in BALB/cByJ mice. (1-2): 47-58. PubMed: 2712823 MGI: 9731
Prochazka M; Leiter E. 1985. A null activity variant found at the butyryl CoA dehydrogenase (Bcd-1) locus in BALB/cByJ subline. 31. MGI: 14034
Armstrong DL; Masiowski ML; Wood PA. 1993. Pathologic characterization of short-chain acyl-CoA dehydrogenase deficiency in BALB/cByJ mice. (6): 884-92. PubMed: 8279487 MGI: 15202
Reue K; Cohen RD. 1996. Acads gene deletion in BALB/cByJ mouse strain occurred after 1981 and is not present in BALB/cByJ-fld mutant mice. (9): 694-5. PubMed: 8703125 MGI: 35700
Guerra C; Koza RA; Walsh K; Kurtz DM; Wood PA; Kozak LP. 1998. Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation. (9): 1724-31. PubMed: 9802886 MGI: 51159
Wood PA; Kelly-Kurtz CL; Hinsdale ME; Hamm DA; Rhead WJ. 1999. Lessons learned from the mouse model of short-chain acyl-CoA dehydrogenase deficiency 395-402. PubMed: 10709668 MGI: 62241
Schuler AM; Gower BA; Matern D; Rinaldo P; Wood PA. 2004. Influence of dietary fatty acid chain-length on metabolic tolerance in mouse models of inherited defects in mitochondrial fatty acid beta-oxidation. (4): 322-9. PubMed: 15589119 MGI: 95652
Schuler AM; Gower BA; Matern D; Rinaldo P; Vockley J; Wood PA. 2005. Synergistic heterozygosity in mice with inherited enzyme deficiencies of mitochondrial fatty acid beta-oxidation. (1): 7-11. PubMed: 15862275 MGI: 99052
Su Z; Leduc MS; Korstanje R; Paigen B. 2010. Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes. (9): 2706-13. PubMed: 20562441 MGI: 165556
Skilling H; Coen PM; Fairfull L; Ferrell RE; Goodpaster BH; Vockley J; Goetzman ES. 2010. Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice. (3): 318-22. PubMed: 20727852 MGI: 166690
Amendt BA; Freneaux E; Reece C; Wood PA; Rhead WJ. 1992. Short-chain acyl-coenzyme A dehydrogenase activity, antigen, and biosynthesis are absent in the BALB/cByJ mouse. (6): 552-6. PubMed: 1635815 MGI: 1360
Kruger C; Kumar KG; Mynatt RL; Volaufova J; Richards BK. 2012. Brain transcriptional responses to high-fat diet in Acads-deficient mice reveal energy sensing pathways. (8): e41709. PubMed: 22936979 MGI: 192778
Wang W; Mohsen AW; Uechi G; Schreiber E; Balasubramani M; Day B; Michael Barmada M; Vockley J. 2014. Complex changes in the liver mitochondrial proteome of short chain acyl-CoA dehydrogenase deficient mice. (1): 30-9. PubMed: 24685553 MGI: 213219
Kaiko GE; Ryu SH; Koues OI; Collins PL; Solnica-Krezel L; Pearce EJ; Pearce EL; Oltz EM; Stappenbeck TS. 2016. The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. (7): 1708-20. PubMed: 27264604 MGI: 235637

Additional - Ahr^b-2

Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. (4): 1315-25. PubMed: 4114109 MGI: 5271
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. (4): 655-9. PubMed: 4750810 MGI: 5376
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. (1): 79-87. PubMed: 7095422 MGI: 6797
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. (4): 471-8. PubMed: 2823093 MGI: 8883
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. (29): 22203-9. PubMed: 8408082 MGI: 15064
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. (5): 915-21. PubMed: 7969080 MGI: 22251
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. (3): 558-62. PubMed: 6021513 MGI: 27884
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. (3): 306-12. PubMed: 2169579 MGI: 34923
Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. (1): 148-59. PubMed: 4716952 MGI: 85290
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. (18): 5851-9. PubMed: 4413562 MGI: 85292
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. (2): 559-64. PubMed: 1119809 MGI: 85293
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. (2 Pt 2 Suppl 1): 393-414. PubMed: 1091656 MGI: 85294
Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. (1): 52-61. PubMed: 9443932 MGI: 46138

Additional - Cdh23^ahl

Noben-Trauth K; Zheng QY; Johnson KR; Nishina PM. 1997. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). (3): 266-72. PubMed: 9325047 MGI: 39072
Johnson KR; Erway LC; Cook SA; Willott JF; Zheng QY. 1997. A major gene affecting age-related hearing loss in C57BL/6J mice (1-2): 83-92. PubMed: 9447922 MGI: 45247
Johnson KR; Zheng QY; Bykhovskaya Y; Spirina O; Fischel-Ghodsian N. 2001. A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. (2): 191-4. PubMed: 11175788 MGI: 68262
Zheng QY; Johnson KR. 2001. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. (1-2): 45-53. PubMed: 11423214 MGI: 71915
Davis RR; Newlander JK; Ling X; Cortopassi GA; Krieg EF; Erway LC. 2001. Genetic basis for susceptibility to noise-induced hearing loss in mice. (1-2): 82-90. PubMed: 11335078 MGI: 70630
Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). (1-2): 31-41. PubMed: 11750125 MGI: 74895
Noben-Trauth K; Zheng QY; Johnson KR. 2003. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. (1): 21-3. PubMed: 12910270 MGI: 87887
Keithley EM; Canto C; Zheng QY; Fischel-Ghodsian N; Johnson KR. 2004. Age-related hearing loss and the ahl locus in mice. (1-2): 21-8. PubMed: 14759567 MGI: 88766
Johnson KR; Zheng QY; Weston MD; Ptacek LJ; Noben-Trauth K. 2005. The Mass1(frings) mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. (5): 582-90. PubMed: 15820310 MGI: 98559
Mathews CE; Leiter EH. 1999. Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. (11): 2189-96. PubMed: 10535453 MGI: 110973
Johnson KR; Zheng QY; Noben-Trauth K. 2006. Strain background effects and genetic modifiers of hearing in mice. (1): 79-88. PubMed: 16579977 MGI: 111541
Vazquez AE; Jimenez AM; Martin GK; Luebke AE; Lonsbury-Martin BL. 2004. Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions. (1-2): 87-96. PubMed: 15276680 MGI: 118835
Liu X; Bulgakov OV; Darrow KN; Pawlyk B; Adamian M; Liberman MC; Li T. 2007. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. (11): 4413-8. PubMed: 17360538 MGI: 120016
Johnson KR; Longo-Guess C; Gagnon LH; Yu H; Zheng QY. 2008. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. (4): 219-25. PubMed: 18662770 MGI: 140316
Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. (3): 290-5. PubMed: 12787792 MGI: 88995
Watson CJ; Tempel BL. 2013. A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers. 41-8. PubMed: 23792079 MGI: 221757
Noben-Trauth K; Latoche JR; Neely HR; Bennett B. 2010. Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. (7): e11459. PubMed: 20628639 MGI: 164213
Johnson KR; Yu H; Ding D; Jiang H; Gagnon LH; Salvi RJ. 2010. Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice. (1-2): 85-92. PubMed: 20470874 MGI: 164131
Perrin BJ; Sonnemann KJ; Ervasti JM. 2010. beta-actin and gamma-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. (10): e1001158. PubMed: 20976199 MGI: 168639
Manji SS; Williams LH; Miller KA; Ooms LM; Bahlo M; Mitchell CA; Dahl HH. 2011. A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. (3): e17607. PubMed: 21423608 MGI: 172797
Han F; Yu H; Tian C; Chen HE; Benedict-Alderfer C; Zheng Y; Wang Q; Han X; Zheng QY. 2012. A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. (1): 30-44. PubMed: 20644563 MGI: 175854
Zilberstein Y; Liberman MC; Corfas G. 2012. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. (2): 405-10. PubMed: 22238076 MGI: 181007
Zheng QY; Scarborough JD; Zheng Y; Yu H; Choi D; Gillespie PG. 2012. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. (11): 2588-98. PubMed: 22381527 MGI: 184994
Kane KL; Longo-Guess CM; Gagnon LH; Ding D; Salvi RJ; Johnson KR. 2012. Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice. (1-2): 80-8. PubMed: 22138310 MGI: 184853
Fetoni AR; Picciotti PM; Paludetti G; Troiani D. 2011. Pathogenesis of presbycusis in animal models: a review. (6): 413-25. PubMed: 21211561 MGI: 188060
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. (8): e43602. PubMed: 22952717 MGI: 192759
Perrin BJ; Strandjord DM; Narayanan P; Henderson DM; Johnson KR; Ervasti JM. 2013. beta-Actin and Fascin-2 Cooperate to Maintain Stereocilia Length. (19): 8114-21. PubMed: 23658152 MGI: 198234
Hurd EA; Adams ME; Layman WS; Swiderski DL; Beyer LA; Halsey KE; Benson JM; Gong TW; Dolan DF; Raphael Y; Martin DM. 2011. Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. (1-2): 184-95. PubMed: 21875659 MGI: 221527
Nagtegaal AP; Rainey RN; van der Pluijm I; Brandt RM; van der Horst GT; Borst JG; Segil N. 2015. Cockayne syndrome group B (csb) and group a (csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. (10): 4280-6. PubMed: 25762674 MGI: 221090
Murillo-Cuesta S; Rodriguez-de la Rosa L; Contreras J; Celaya AM; Camarero G; Rivera T; Varela-Nieto I. 2015. Transforming growth factor beta1 inhibition protects from noise-induced hearing loss. 32. PubMed: 25852546 MGI: 243628
Johnson KR; Tian C; Gagnon LH; Jiang H; Ding D; Salvi R. 2017. Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains. 44450. PubMed: 28287619 MGI: 242229
Miyasaka Y; Suzuki S; Ohshiba Y; Watanabe K; Sagara Y; Yasuda SP; Matsuoka K; Shitara H; Yonekawa H; Kominami R; Kikkawa Y. 2013. Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice. (4): 333-46. PubMed: 24172198 MGI: 266552
Zhang C; Sun W; Li J; Xiong B; Frye MD; Ding D; Salvi R; Kim MJ; Someya S; Hu BH. 2017. Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. 179-191. PubMed: 28818524 MGI: 260243

Additional - Hld

Barber RP; Vaughn JE; Wimer RE; Wimer CC. 1974. Genetically-associated variations in the distribution of dentate granule cell synapses upon the pyramidal cell dendrites in mouse hippocampus. (4): 417-34. PubMed: 4137683 MGI: 5475
Vaughn JE; Matthews DA; Barber RP; Wimer CC; Wimer RE. 1977. Genetically-associated variations in the development of hippocampal pyramidal neurons may produce differences in mossy fiber connectivity. (1): 41-51. PubMed: 845286 MGI: 5776
Nowakowski RS; Davis TL. 1985. Dendritic arbors and dendritic excrescences of abnormally positioned neurons in area CA3c of mice carrying the mutation hippocampal lamination defect. (3): 267-75. PubMed: 4044940 MGI: 12003
Nowakowski RS. 1984. The mode of inheritance of a defect in lamination in the hippocampus of BALB/c mice. (3): 249-58. PubMed: 6536729 MGI: 7935
Nowakowski RS. 1984. Hippocampal lamination defect = Hld. 35. MGI: 13923

Technical Support

Contact Technical Support

Genotyping Protocols
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is a good breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- albino
  Related Genotype: A/A Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c

Animal Health Reports

Facility Barrier Level Descriptions

AX8 (Standard)

RB09 (Maximum)

MP14 (Maximum)

Pricing & Availability

Readily Available

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Please inquire

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: CByJ, BALB Bailey, BALB/c Bailey J, CBy

Genetic overview

Research Applications

Base Price

Important Note

Detailed Description

Development

Selected References

Hld

Allele Symbol: Hld

Ahrb-2

Allele Symbol: Ahrb-2

Cdh23ahl

Allele Symbol: Cdh23ahl

Acadsdel-J

Allele Symbol: Acadsdel-J

Mdmg1

Marker Symbol: Mdmg1

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23ahl related

Mammalian Phenotype Terms by Genotype

Genotype: Acadsdel-J/Acadsdel-JBALB/cByJ

nervous system phenotype

behavior/neurological phenotype

homeostasis/metabolism phenotype

liver/biliary system phenotype

renal/urinary system phenotype

cellular phenotype

muscle phenotype

Genotype: Hld/Hldeither: BALB/cByJ or BALB/cJ

nervous system phenotype

cellular phenotype

Phenotype Information

References

Additional References

Additional - Acadsdel-J

Additional - Ahrb-2

Additional - Cdh23ahl

Additional - Hld

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Ahr^b-2

Allele Symbol: Ahr^b-2

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Acads^del-J

Allele Symbol: Acads^del-J

Genotype: Cdh23^ahl related

Genotype: Acads^del-J/Acads^del-J
BALB/cByJ

Genotype: Hld/Hld
either: BALB/cByJ or BALB/cJ

Additional - Acads^del-J

Additional - Ahr^b-2

Additional - Cdh23^ahl