BALB/cByJ

Stock No:: 001026

Also Known As:BALB/c Bailey J, BALB Bailey, CBy, CByJ

Mice of this substrain of BALB/c, among other differences, have better reproductive performance and less aggression than mice of the BALB/cJ substrain (Stock No. 000651).

Genetic overview

Genetic Background	Generation
	Contact Technical Support (2018-07-27 00:00:00)

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Research Applications

Neurobiology Research
Research Tools
Immunology, Inflammation and Autoimmunity Research
Cancer Research
Sensorineural Research

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Base Price

Starting at:

$34.16 Domestic price for female 3-week

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Details

Important Note

This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.

Detailed Description

BALB/c mice are particularly well known for the production of plasmacytoma on injection with mineral oil, forming the basis for the production of monoclonal antibodies. Although not all BALB/c substrains have been examined for plasmacytoma induction, substrains derived from the Andervont (An) lineage (which includes BALB/cByJ) typically are susceptible, while those descended from BALB/cJ are resistant. Mammary tumor incidence is normally low, but infection with mammary tumor virus by fostering to MMTV⁺ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life, including reticular neoplasm, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains. A deficiency of Acads (acyl-Coenzyme A dehydrogenase, short chain) leads to severe organic aciduria. BALB/cByJ develop a fatty liver upon fasting or dietary fat challenge and become hypoglycemic after an 18-hour fast. BALB/cByJ mice have the advantage of better reproductive performance and less aggression than mice of the BALB/cJ substrain.

Development

This is a substrain of BALB (Bagg’s albino) derived initially from the BALB strain maintained by MacDowell at Cold Spring Harbor, eventually sent to Andervont as BALB/cAn and to NIH where D.W. Bailey obtained the substrain and maintained it through locations at the University of California Medical School at San Francisco and ultimately at The Jackson Laboratory. In 1975 at generation F136 BALB/cBy (Stock No. 000650) mice were sent to JAX production facility upon hysterectomy derivation and became the BALB/cByJ substrain.

The Andervont/Bailey lineage and the lineage giving rise to BALB/cJ were separated from the BALB/c line maintained by Snell at The Jackson Laboratory during the period of 1937 to 1939 around generation F36.

Selected References

Hinsdale ME; Kelly CL; Wood PA. 1993. Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA. Genomics 16(3):605-11PubMed: 8325633 MGI: J:12776
Wood PA; Hinsdale ME; Kelly CL. 1993. Molecular detection of the Bcd-1 null allele in BALB/cByJ mice by polymerase chain reaction: a simple assay for genetic monitoring Mouse Genome 91(2):342-44MGI: J:12812
Champy MF; Selloum M; Zeitler V; Caradec C; Jung B; Rousseau S; Pouilly L; Sorg T; Auwerx J. 2008. Genetic background determines metabolic phenotypes in the mouse. Mamm Genome 19(5):318-31PubMed: 18392653 MGI: J:137669
Wood PA; Amendt BA; Rhead WJ; Millington DS; Inoue F; Armstrong D. 1989. Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. Pediatr Res 25(1):38-43PubMed: 2919115 MGI: J:14707
Sundberg JP; Hanson CA; Roop DR; Brown KS; Bedigian HG. 1991. Myoepitheliomas in inbred laboratory mice. Vet Pathol 28(4):313-23PubMed: 1719689 MGI: J:22767
Ebbesen P. 1971. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. J Natl Cancer Inst 47(6):1241-5PubMed: 4941118 MGI: J:24297
Roderick TH; Langley SH; Leiter EH. 1985. Some unusual genetic characteristics of BALB/c and evidence for genetic variation among BALB/c substrains. Curr Top Microbiol Immunol 122:9-18PubMed: 3899524 MGI: J:24307
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8PubMed: 4322934 MGI: J:24674
Bentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A 67(1):377-84PubMed: 4318784 MGI: J:24803
Smith Richards BK; Belton BN; York B; Volaufova J. 2004. Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat. Am J Physiol Regul Integr Comp Physiol 286(2):R311-9PubMed: 14592933 MGI: J:87779
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

View All References

Genetics

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	age related hearing loss 1; Cdh23^ahl
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	bob; bustling; bobby; nmf112; nmf252; nmf252; 4930542A03Rik; ahl; 4930542A03Rik; W; sals; mdfw; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; modifier of deaf waddler; age related hearing loss 1; v; USH1D; nmf181; RIKEN cDNA 4930542A03 gene; CDHR23; sals; waltzer; nmf112; nmf181; mdfw; neuroscience mutagenesis facility, 112; bus; ahl; bob; salsa; PITA5
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Ahr^b-2

Allele Symbol: Ahr^b-2

Allele Name	b-2 variant
Allele Type	Not Applicable
Allele Synonym(s)	b-2 variant; Ahr^b-2
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	bHLHe76; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; Ahh; dioxin receptor; In; Ah; Ahre; inflammatory reactivity; RP85
Strain of Origin	BALB/cBy
Chromosome	12
General Note	C57BL/6 carries the responsive Ahr^b allele; DBA/2 carries nonresponsive Ahr^d. Heterozygotes (Ahr^b/Ahr^d) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahr^b-1; Ahr^b-2 is carried by BALB/cBy, A, and C3H; and Ahr^b-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahr^b-1 and Ahr^d have been determined (J:17460). Strain of origin - this allele was found in BALB/cByJ, A/J, C3H/HeJ, CBA strains
Molecular Note	This allele encodes a high affinity, heat labile, 104 kDa receptor containing 848 amino acids. Sequencing studies of cDNA from C57BL/6J congenic mice homozygous for this allele identified nucleotide substitutions in the ORF that would cause 5 amino acid differences between the C57BL/6J and BALB/cBy peptides, and 2 amino acid differences between the BALB/cBy and DBA/2J peptides. A T to C transition in exon 11 replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the BALB/cBy allele. This change would extend translation of the BALB/cBy mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa, vs 95 kDa for the C57BL/6J allele).

If1^l

Allele Symbol: If1^l

Allele Name	low response
Allele Type	Spontaneous (Hypomorph)
Allele Synonym(s)	If1^l; low response
Gene Symbol and Name	If1, NDV-induced circulating interferon
Gene Synonym(s)	If-1; If-1
Strain of Origin	BALB/c
Chromosome	3
Molecular Note	This phenotypic variation causing decreased interferon production in response to particular stimuli has been mapped to distal Chromosome 3

Acads^del-J

Allele Symbol: Acads^del-J

Allele Name	deletion, Jackson
Allele Type	Spontaneous
Allele Synonym(s)	deletion, Jackson; Acads^del-J
Gene Symbol and Name	Acads, acyl-Coenzyme A dehydrogenase, short chain
Gene Synonym(s)	Hdlq8; AI196007; Bcd-1; Bcd1; butyryl CoA dehydrogenase 1; ACAD3; expressed sequence AI196007; HDL QTL 8; Hdlq8; SCAD; Bcd-1; Bcd1; Scad
Strain of Origin	BALB/cByJ
Chromosome	5
Molecular Note	A 278bp deletion occurs which starts in intron "A" and includes exon "B" and the first 78bp of exon "C". As a result of this deletion, mRNA transcription is reduced to about 35% of normal and includes two forms, a longer normal length transcript and a shorter misspliced form. If these mRNAs were translated they both would result in truncated products. Protein product is undetectable immunologically and there is a total absence of enzyme activity.

Hld

Allele Symbol: Hld

Allele Name	hippocampal lamination defect
Allele Type	Spontaneous
Allele Synonym(s)	hippocampal lamination defect; Hld
Gene Symbol and Name	Hld, hippocampal lamination defect
Gene Synonym(s)
Strain of Origin	BALB/cJ
Chromosome	UN

Mdmg1

Marker Symbol: Mdmg1

Marker Synonym(s)	Mdmg-1; Mdmg-1
Chromosome(s)	17

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

short chain acyl-CoA dehydrogenase deficiency

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Neurodevelopmental Defects
  - callosal agenesis, incomplete penetrance
- Hearing Defects
  - Age related hearing loss
Research Tools
- Cancer Research
  - monoclonal antibodies, myeloma and hybridoma production
- General Purpose
- Immunology, Inflammation and Autoimmunity Research
  - background strain for histocompatibility congenics
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimental allergic encephalomyelitis (EAE)
Cancer Research
- Increased Tumor Incidence
  - Mammary Gland Tumors
  - Mammary Gland Tumors: late onset
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Acads^del-J/Acads^del-J
involves: BALB/cByJ

behavior/neurological phenotype

abnormal food preference
- given a choice, selection of a fat/protein diet declines with time

abnormal liquid preference
- did not develop a preference for drinking water containing a corn oil emulsion

liver/biliary system phenotype

hepatic steatosis
- fat deposits accumulate in the liver after 18 hours of fasting or with dietary fat challenge

muscle phenotype

abnormal skeletal muscle morphology
- wehn dosed with carnitine, mutant muscle exhibits a 9-fold increase in butyryl-carnitine concentration compared to controls

nervous system phenotype

decreased circulating glycine level
- serum glycine concentrations are markedly lower than in controls

renal/urinary system phenotype

ethylmalonic aciduria
- ethylmalonate urinary excretion is higher than in controls
- relatively large amounts of ethylmalonate in the urine at 7-14 weeks of age

organic aciduria
- ethylmalonate, methylsuccinate, and butyrylglycine urinary excretion is higher than in controls
- markedly increased urinary concentrations of ethylmalonic and methylsuccinic acids, and N-butyrylglycine in nonfasting and fasting mice, and remained elevated with or without medium chain triglyceride challenge
- organic aciduria at 7-14 weeks of age, caused by relatively large amounts of n-butyrylglycine and ethylmalonate in the urine
- upon dosing with carnitine, mice excrete large amounts of butyryl-carnitine in the urine

cellular phenotype

abnormal fatty acid oxidation
- block in short-chain fatty acid oxidation shown by reduced butyryl-CoA dehydrogenation in liver mitochondria

homeostasis/metabolism phenotype

abnormal adaptive thermogenesis
- body temperature in most BALB/cByJ mice dropped 10 degrees C in less than 4 h at 4 degrees C, with none able to maintain body temperature for longer than 8 h in the cold

abnormal fatty acid oxidation
- block in short-chain fatty acid oxidation shown by reduced butyryl-CoA dehydrogenation in liver mitochondria

decreased circulating carnitine level
- slightly lower plasma carnitine level

decreased circulating glycine level
- serum glycine concentrations are markedly lower than in controls

ethylmalonic aciduria
- ethylmalonate urinary excretion is higher than in controls
- relatively large amounts of ethylmalonate in the urine at 7-14 weeks of age

hypoglycemia
- hypoglycemia develops after 18 hours of fasting with mean serum glucose measuring less than half of control values

increased circulating HDL cholesterol level
- HDL levels were significantly increased in mutant mice for both males and females fed either a regular chow or a high-fat diet

organic aciduria
- ethylmalonate, methylsuccinate, and butyrylglycine urinary excretion is higher than in controls
- markedly increased urinary concentrations of ethylmalonic and methylsuccinic acids, and N-butyrylglycine in nonfasting and fasting mice, and remained elevated with or without medium chain triglyceride challenge
- organic aciduria at 7-14 weeks of age, caused by relatively large amounts of n-butyrylglycine and ethylmalonate in the urine
- upon dosing with carnitine, mice excrete large amounts of butyryl-carnitine in the urine

Genotype: Hld/Hld
either: (involves: BALB/cByJ) or (involves: BALB/cJ)

cellular phenotype

abnormal neuronal migration

nervous system phenotype

abnormal dendrite morphology
- abnormally positioned by being late-generated
- cell bodies are located below the intrapyramidal mossy fiber layer

abnormal hippocampal mossy fiber morphology

abnormal hippocampus CA3 region morphology
- there is abnormal lamination of this cell layer resulting in superficial early generated neurons and deep late-generated neurons

abnormal hippocampus layer morphology
- Background Sensitivity - the anomaly is also seen in BALB/cByJ, F1 mice involving BALB sublines noted, and some CXB RI lines; C57BL/6J is considered wild-type for this feature
- this is secondary to a defect in neuronal migration

abnormal hippocampus morphology

abnormal neuronal migration

ectopic hippocampus pyramidal cells
- located below the intrapyramidal layer; some of the ectopic cells have short, fine-caliber dendritic branches arising near the points of contact of the intrapyramidal mossy fibers

Phenotype Information

Body Weight Information - JAX^® Mice Strain BALB/cByJ (001026)
Festing Inbred Strain Characteristics: BALB/c
JAX^® Physiological Data Summary [pdf]
Mouse Phenome Database / SNP Facility

References

Hinsdale ME; Kelly CL; Wood PA. 1993. Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA. Genomics 16(3):605-11PubMed: 8325633 MGI: J:12776
Wood PA; Hinsdale ME; Kelly CL. 1993. Molecular detection of the Bcd-1 null allele in BALB/cByJ mice by polymerase chain reaction: a simple assay for genetic monitoring Mouse Genome 91(2):342-44MGI: J:12812
Champy MF; Selloum M; Zeitler V; Caradec C; Jung B; Rousseau S; Pouilly L; Sorg T; Auwerx J. 2008. Genetic background determines metabolic phenotypes in the mouse. Mamm Genome 19(5):318-31PubMed: 18392653 MGI: J:137669
Wood PA; Amendt BA; Rhead WJ; Millington DS; Inoue F; Armstrong D. 1989. Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. Pediatr Res 25(1):38-43PubMed: 2919115 MGI: J:14707
Sundberg JP; Hanson CA; Roop DR; Brown KS; Bedigian HG. 1991. Myoepitheliomas in inbred laboratory mice. Vet Pathol 28(4):313-23PubMed: 1719689 MGI: J:22767
Ebbesen P. 1971. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. J Natl Cancer Inst 47(6):1241-5PubMed: 4941118 MGI: J:24297
Roderick TH; Langley SH; Leiter EH. 1985. Some unusual genetic characteristics of BALB/c and evidence for genetic variation among BALB/c substrains. Curr Top Microbiol Immunol 122:9-18PubMed: 3899524 MGI: J:24307
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8PubMed: 4322934 MGI: J:24674
Bentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A 67(1):377-84PubMed: 4318784 MGI: J:24803
Smith Richards BK; Belton BN; York B; Volaufova J. 2004. Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat. Am J Physiol Regul Integr Comp Physiol 286(2):R311-9PubMed: 14592933 MGI: J:87779
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

Additional References

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Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20PubMed: 16971002 MGI: J:138682
Srivastava B; Blazejewska P; Hessmann M; Bruder D; Geffers R; Mauel S; Gruber AD; Schughart K. 2009. Host genetic background strongly influences the response to influenza a virus infections. PLoS One 4(3):e4857PubMed: 19293935 MGI: J:147356
Milner LC; Crabbe JC. 2008. Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav 7(4):496-505PubMed: 18182070 MGI: J:149042
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Xing S; Tsaih SW; Yuan R; Svenson KL; Jorgenson LM; So M; Paigen BJ; Korstanje R. 2009. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 296(6):H1907-13PubMed: 19395551 MGI: J:150867
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Zombeck JA; Swearingen SP; Rhodes JS. 2010. Acute locomotor responses to cocaine in adolescents vs. adults from four divergent inbred mouse strains. Genes Brain Behav 9(8):892-8PubMed: 20662938 MGI: J:178207
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Crowley JJ; Kim Y; Szatkiewicz JP; Pratt AL; Quackenbush CR; Adkins DE; van den Oord E; Bogue MA; Yang H; Wang W; Threadgill DW; de Villena FP; McLeod HL; Sullivan PF. 2012. Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice. Mamm Genome 23(5-6):322-35PubMed: 22207321 MGI: J:179972
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Van Der Kraak L; Langlais D; Jothy S; Beauchemin N; Gros P. 2016. Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice. Mamm Genome 27(5-6):213-24PubMed: 26979842 MGI: J:242437
Sundberg JP; Awgulewitsch A; Pruett ND; Potter CS; Silva KA; Stearns TM; Sundberg BA; Munoz MW; Cuasnicu PS; King LE Jr; Rice RH. 2014. Crisp1 and alopecia areata in C3H/HeJ mice. Exp Mol Pathol 97(3):525-8PubMed: 25446841 MGI: J:244188
Liu JL; Wang TS; Zhao M. 2016. Genome-Wide Association Mapping for Female Infertility in Inbred Mice. G3 (Bethesda) 6(9):2929-35PubMed: 27449513 MGI: J:244239
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Sittig LJ; Jeong C; Tixier E; Davis J; Barrios-Camacho CM; Palmer AA. 2014. Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ. Mamm Genome 25(11-12):564-72PubMed: 24997021 MGI: J:250048
Boon AC; Finkelstein D; Zheng M; Liao G; Allard J; Klumpp K; Webster R; Peltz G; Webby RJ. 2011. H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. MBio 2(5)PubMed: 21896679 MGI: J:267274
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Teng BL; Nonneman RJ; Agster KL; Nikolova VD; Davis TT; Riddick NV; Baker LK; Pedersen CA; Jarstfer MB; Moy SS. 2013. Prosocial effects of oxytocin in two mouse models of autism spectrum disorders. Neuropharmacology 72:187-96PubMed: 23643748 MGI: J:268982
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of water and sodium intake. Physiol Behav 91(5):620-31PubMed: 17490693 MGI: J:269806
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav 91(5):632-43PubMed: 17493644 MGI: J:272216
Reed DR; Bachmanov AA; Tordoff MG. 2007. Forty mouse strain survey of body composition. Physiol Behav 91(5):593-600PubMed: 17493645 MGI: J:272217
Bumgardner SA; Zhou Y; Jiang Z; Coe EJ; Yakaitis CL; Xiao Y; Pazdro R. 2018. Genetic influence on splenic natural killer cell frequencies and maturation among aged mice. Exp Gerontol 104:9-16PubMed: 29355703 MGI: J:272690
Srivastava S; Salter AI; Liggitt D; Yechan-Gunja S; Sarvothama M; Cooper K; Smythe KS; Dudakov JA; Pierce RH; Rader C; Riddell SR. 2019. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell 35(3):489-503.e8PubMed: 30889382 MGI: J:273225
Velez L; Sokoloff G; Miczek KA; Palmer AA; Dulawa SC. 2010. Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains. Behav Genet 40(2):201-10PubMed: 20033273 MGI: J:275167
Zimmerman H; Yin Z; Zou F; Everett ET. 2019. Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping. Front Genet 10:291PubMed: 31001328 MGI: J:275176
Geuther BQ; Deats SP; Fox KJ; Murray SA; Braun RE; White JK; Chesler EJ; Lutz CM; Kumar V. 2019. Robust mouse tracking in complex environments using neural networks. Commun Biol 2:124PubMed: 30937403 MGI: J:275426
Byers SL; Payson SJ; Taft RA. 2006. Performance of ten inbred mouse strains following assisted reproductive technologies (ARTs). Theriogenology 65(9):1716-26PubMed: 16271754 MGI: J:275449
Kutlu MG; Ortega LA; Gould TJ. 2015. Strain-dependent performance in nicotine-induced conditioned place preference. Behav Neurosci 129(1):37-41PubMed: 25546366 MGI: J:275450
O'Leary TP; Savoie V; Brown RE. 2011. Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze. Behav Brain Res 216(2):531-42PubMed: 20801160 MGI: J:275452
Brown RE; Wong AA. 2007. The influence of visual ability on learning and memory performance in 13 strains of mice. Learn Mem 14(3):134-44PubMed: 17351136 MGI: J:275455
Bolivar VJ. 2009. Intrasession and intersession habituation in mice: from inbred strain variability to linkage analysis. Neurobiol Learn Mem 92(2):206-14PubMed: 19496240 MGI: J:275782
Frick A; Fedoriw Y; Richards K; Damania B; Parks B; Suzuki O; Benton CS; Chan E; Thomas RS; Wiltshire T. 2015. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med 8:81-98PubMed: 25897258 MGI: J:275938
Vinyard CJ; Payseur BA. 2008. Of mice and mammals: utilizing classical inbred mice to study the genetic architecture of function and performance in mammals. Integr Comp Biol 48(3):324-37PubMed: 21669795 MGI: J:275940
Tomasini-Johansson B; Mosher DF. 2009. Plasma fibronectin concentration in inbred mouse strains. Thromb Haemost 102(6):1278-80PubMed: 19967162 MGI: J:275941
Thomsen M; Ralph RJ; Caine SB. 2011. Psychomotor stimulation by dopamine D(1)-like but not D(2)-like agonists in most mouse strains. Exp Clin Psychopharmacol 19(5):342-60PubMed: 21843011 MGI: J:275942
Thomsen M; Caine SB. 2011. Psychomotor stimulant effects of cocaine in rats and 15 mouse strains. Exp Clin Psychopharmacol 19(5):321-41PubMed: 21843010 MGI: J:275943
Schoenrock SA; Oreper D; Young N; Ervin RB; Bogue MA; Valdar W; Tarantino LM. 2016. Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav 167:404-412PubMed: 27693591 MGI: J:275944
Wooley CM; Xing S; Burgess RW; Cox GA; Seburn KL. 2009. Age, experience and genetic background influence treadmill walking in mice. Physiol Behav 96(2):350-61PubMed: 19027767 MGI: J:275950
Bradford BU; Lock EF; Kosyk O; Kim S; Uehara T; Harbourt D; DeSimone M; Threadgill DW; Tryndyak V; Pogribny IP; Bleyle L; Koop DR; Rusyn I. 2011. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci 120(1):206-17PubMed: 21135412 MGI: J:275951
Tsuchiya M; Ji C; Kosyk O; Shymonyak S; Melnyk S; Kono H; Tryndyak V; Muskhelishvili L; Pogribny IP; Kaplowitz N; Rusyn I. 2012. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology 56(1):130-9PubMed: 22307928 MGI: J:275956
Lin X; Yue P; Chen Z; Schonfeld G. 2005. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol 288(6):G1179-89PubMed: 15591160 MGI: J:275968
Metten P; Crabbe JC. 2005. Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behav Neurosci 119(4):911-25PubMed: 16187819 MGI: J:276057
Ishiwatari Y; Bachmanov AA. 2012. NaCl taste thresholds in 13 inbred mouse strains. Chem Senses 37(6):497-508PubMed: 22293936 MGI: J:276118
Lad HV; Liu L; Paya-Cano JL; Parsons MJ; Kember R; Fernandes C; Schalkwyk LC. 2010. Behavioural battery testing: evaluation and behavioural outcomes in 8 inbred mouse strains. Physiol Behav 99(3):301-16PubMed: 19931548 MGI: J:276120
Kilikevicius A; Venckunas T; Zelniene R; Carroll AM; Lionikaite S; Ratkevicius A; Lionikas A. 2013. Divergent physiological characteristics and responses to endurance training among inbred mouse strains. Scand J Med Sci Sports 23(5):657-68PubMed: 22414113 MGI: J:276367
Serpi R; Klein-Rodewald T; Calzada-Wack J; Neff F; Schuster T; Gailus-Durner V; Fuchs H; Poutanen M; Hrabre de Angelis M; Esposito I. 2013. Inbred wild type mouse strains have distinct spontaneous morphological phenotypes. Histol Histopathol 28(1):79-88PubMed: 23233061 MGI: J:276467
Avila JJ; Kim SK; Massett MP. 2017. Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains. Front Physiol 8:974PubMed: 29249981 MGI: J:276478
Chen YG; Tsaih SW; Serreze DV. 2012. Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. Genes Immun 13(2):164-74PubMed: 21938016 MGI: J:276531
Crabbe JC; Metten P; Yu CH; Schlumbohm JP; Cameron AJ; Wahlsten D. 2003. Genotypic differences in ethanol sensitivity in two tests of motor incoordination. J Appl Physiol (1985) 95(4):1338-51PubMed: 12704090 MGI: J:276533
Berndt A; Leme AS; Williams LK; Von Smith R; Savage HS; Stearns TM; Tsaih SW; Shapiro SD; Peters LL; Paigen B; Svenson KL. 2011. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics 43(1):1-11PubMed: 20823217 MGI: J:276536
O'Leary TP; Gunn RK; Brown RE. 2013. What are we measuring when we test strain differences in anxiety in mice? Behav Genet 43(1):34-50PubMed: 23288504 MGI: J:276587
Leme AS; Berndt A; Williams LK; Tsaih SW; Szatkiewicz JP; Verdugo R; Paigen B; Shapiro SD. 2010. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics 283(4):317-26PubMed: 20143096 MGI: J:276589
Schauwecker PE. 2012. Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus. Neurobiol Dis 45(1):297-304PubMed: 21878392 MGI: J:276609
Deschepper CF; Olson JL; Otis M; Gallo-Payet N. 2004. Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains. J Appl Physiol (1985) 97(1):369-76PubMed: 15047670 MGI: J:276748
Beamer WG; Donahue LR; Rosen CJ; Baylink DJ. 1996. Genetic variability in adult bone density among inbred strains of mice. Bone 18(5):397-403PubMed: 8739896 MGI: J:33789
Srivastava RA; Bhasin N; Srivastava N. 1996. Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen. Biochem Mol Biol Int 38(1):91-101PubMed: 8932523 MGI: J:36349
Scott P; Eaton A; Gause WC; di Zhou X; Hondowicz B. 1996. Early IL-4 production does not predict susceptibility to Leishmania major. Exp Parasitol 84(2):178-87PubMed: 8932767 MGI: J:37598
Stitzel JA; Farnham DA; Collins AC. 1996. Linkage of strain-specific nicotinic receptor alpha 7 subunit restriction fragment length polymorphisms with levels of alpha-bungarotoxin binding in brain. Brain Res Mol Brain Res 43(1-2):30-40PubMed: 9037516 MGI: J:37665
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805PubMed: 10749765 MGI: J:61602
Bolivar VJ; Caldarone BJ; Reilly AA; Flaherty L. 2000. Habituation of activity in an open field: A survey of inbred strains and F1 hybrids. Behav Genet 30(4):285-93PubMed: 11206083 MGI: J:67085
Bolivar VJ; Pooler O; Flaherty L. 2001. Inbred strain variation in contextual and cued fear conditioning behavior. Mamm Genome 12(8):651-6PubMed: 11471061 MGI: J:70826
Flaherty L; DiBiase K; Lynes MA; Seidman JG; Weinberger O; Rinchik EM. 1985. Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci U S A 82(5):1503-7PubMed: 2983348 MGI: J:7763
Dobelis P; Marks MJ; Whiteaker P; Balogh SA; Collins AC; Stitzel JA. 2002. A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function. Mol Pharmacol 62(2):334-42PubMed: 12130686 MGI: J:78831
Bouwknecht JA; Paylor R. 2002. Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains. Behav Brain Res 136(2):489-501PubMed: 12429412 MGI: J:80397
Bachmanov AA; Beauchamp GK; Tordoff MG. 2002. Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains. Behav Genet 32(6):445-57PubMed: 12467342 MGI: J:80489
Bachmanov AA; Reed DR; Beauchamp GK; Tordoff MG. 2002. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 32(6):435-43PubMed: 12467341 MGI: J:80495
Rustay NR; Wahlsten D; Crabbe JC. 2003. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A 100(5):2917-22PubMed: 12584362 MGI: J:82386
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9PubMed: 12884964 MGI: J:83104
Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54PubMed: 12691836 MGI: J:83159

Additional - If1^l related

Additional - Acads^del-J related

Additional - Ahr^b-2 related

Additional - Cdh23^ahl related

Additional - Hld related

Additional - Mdmg1 related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Sanger sequencing:H2 rs50413633
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is a good breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- albino
  Related Genotype: A/A Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c
Citation
When using the BALB/cByJ mouse strain in a publication, please include JAX stock #001026 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

AX8 (Standard)

RB09 (Maximum)

MP14 (Maximum)

Pricing & Availability

Readily Available

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Please inquire

Related Products and Services

Mouse ES Cells	BALB/cByJ-PB150.18 mES cells	$695.00
Mouse ES Cells	BALB/cByJ AC383/GrsrJ mES cells	$995.00
Mouse ES Cells	BALB/cByJ-PB150.18 mES cells	$695.00
Mouse ES Cells	BALB/cByJ AC383/GrsrJ mES cells	$995.00
Mouse ES Cells	BALB/cByJ-PB150.18 mES cells	$695.00
Mouse ES Cells	BALB/cByJ AC383/GrsrJ mES cells	$995.00
Mouse ES Cells	BALB/cByJ-PB150.18 mES cells	$695.00
Mouse ES Cells	BALB/cByJ AC383/GrsrJ mES cells	$995.00

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As:BALB/c Bailey J, BALB Bailey, CBy, CByJ

Genetic overview

Research Applications

Base Price

Important Note

Detailed Description

Development

Selected References

Cdh23ahl

Allele Symbol: Cdh23ahl

Ahrb-2

Allele Symbol: Ahrb-2

If1l

Allele Symbol: If1l

Acadsdel-J

Allele Symbol: Acadsdel-J

Hld

Allele Symbol: Hld

Mdmg1

Marker Symbol: Mdmg1

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23ahl related

Mammalian Phenotype Terms by Genotype

Genotype: Acadsdel-J/Acadsdel-Jinvolves: BALB/cByJ

behavior/neurological phenotype

liver/biliary system phenotype

muscle phenotype

nervous system phenotype

renal/urinary system phenotype

cellular phenotype

homeostasis/metabolism phenotype

Genotype: Hld/Hldeither: (involves: BALB/cByJ) or (involves: BALB/cJ)

cellular phenotype

nervous system phenotype

Phenotype Information

References

Additional References

Additional - If1l related

Additional - Acadsdel-J related

Additional - Ahrb-2 related

Additional - Cdh23ahl related

Additional - Hld related

Additional - Mdmg1 related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Related Products and Services

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Ahr^b-2

Allele Symbol: Ahr^b-2

If1^l

Allele Symbol: If1^l

Acads^del-J

Allele Symbol: Acads^del-J

Genotype: Cdh23^ahl related

Genotype: Acads^del-J/Acads^del-J
involves: BALB/cByJ

Genotype: Hld/Hld
either: (involves: BALB/cByJ) or (involves: BALB/cJ)

Additional - If1^l related

Additional - Acads^del-J related

Additional - Ahr^b-2 related

Additional - Cdh23^ahl related