RBD/DnJ

Stock number: 001000
Research areas: Endocrine Deficiency Research, Research Tools

Detailed description

Mice of this strain are homozygous for the Robertsonian chromosomes Rb(5.15)3Bnr, Rb(11.13)4Bnr and Rb(16.17)7Bnr.

Development

This strain was derived from crosses of Swiss mice with wild mice captured in the Valle di Poschiavo in SE Switzerland. The wild population was originally known as the 'tobacco' mouse because of their dark coat color. They also appear in the literature as Mus poschiavinus. The strain was obtained by T. Roderick from A. Gropp in 1970, then to M. Davisson in 1981. It was cryopreserved in 1985 at F61.

Allele

Symbol: Mc1r^E-tob
Name: tobacco darkening
MGI accession ID: MGI:1856030
Generation method: Spontaneous
Marker symbol: Mc1r
Marker name: melanocortin 1 receptor
Chromosome: 8
Strain of origin: M. m. domesticus poschiavinus
Molecular note: Two independent PCR assays found a C-to-T mutation at coding nucleotide 206 resulting in a serine to leucine alteration in codon 69 (p.S69L). A second nucleotide C-to-T change results in a silent mutation at position 166. The result is a receptor that is overactive, though responsive to hormone regulation, and produces a greater activation of the MC1R effector, G protein-coupled adenylyl cyclase, than does the wild-type allele.

Allele

MGI accession ID: MGI:104201
Marker symbol: Rb(16.17)7Bnr
Marker name: Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7
Chromosome: 17

Allele

MGI accession ID: MGI:104200
Marker symbol: Rb(16.17)7Bnr
Marker name: Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7
Chromosome: 16

Allele

MGI accession ID: MGI:103849
Marker symbol: Rb(5.15)3Bnr
Marker name: Robertsonian translocation, Chr 5 and 15, Universitat Bonn/Rhein 3
Chromosome: 15

Allele

MGI accession ID: MGI:104099
Marker symbol: Rb(11.13)4Bnr
Marker name: Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4
Chromosome: 13

Allele

MGI accession ID: MGI:104098
Marker symbol: Rb(11.13)4Bnr
Marker name: Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4
Chromosome: 11

Allele

MGI accession ID: MGI:103848
Marker symbol: Rb(5.15)3Bnr
Marker name: Robertsonian translocation, Chr 5 and 15, Universitat Bonn/Rhein 3
Chromosome: 5