Mice of this strain are homozygous for the Robertsonian chromosomes Rb(5.15)3Bnr, Rb(11.13)4Bnr and Rb(16.17)7Bnr.
Mice of this strain are homozygous for the Robertsonian chromosomes Rb(5.15)3Bnr, Rb(11.13)4Bnr and Rb(16.17)7Bnr.
This strain was derived from crosses of Swiss mice with wild mice captured in the Valle di Poschiavo in SE Switzerland. The wild population was originally known as the 'tobacco' mouse because of their dark coat color. They also appear in the literature as Mus poschiavinus. The strain was obtained by T. Roderick from A. Gropp in 1970, then to M. Davisson in 1981. It was cryopreserved in 1985 at F61.
Allele Name | tobacco darkening |
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Allele Type | Spontaneous |
Allele Synonym(s) | Etob |
Gene Symbol and Name | Mc1r, melanocortin 1 receptor |
Gene Synonym(s) | |
Strain of Origin | M. m. domesticus poschiavinus |
Chromosome | 8 |
Molecular Note | Two independent PCR assays found a C-to-T mutation at coding nucleotide 206 resulting in a serine to leucine alteration in codon 69 (p.S69L). A second nucleotide C-to-T change results in a silent mutation at position 166. The result is a receptor that is overactive, though responsive to hormone regulation, and produces a greater activation of the MC1R effector, G protein-coupled adenylyl cyclase, than does the wild-type allele. |
Marker Synonym(s) | |
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Chromosome(s) | 17 |
Marker Synonym(s) | |
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Chromosome(s) | 15 |
Marker Synonym(s) | |
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Chromosome(s) | 13 |
Marker Synonym(s) | |
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Chromosome(s) | 16 |
Marker Synonym(s) | |
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Chromosome(s) | 11 |
Marker Synonym(s) | |
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Chromosome(s) | 5 |
When using the RBD/DnJ mouse strain in a publication, please include JAX stock #001000 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous , 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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