B6.B10(PL)-Slc45a2^Uw-dbr/J

Stock number: 000977
Product name: underwhite dominant brown
Research areas: Dermatology Research

Detailed description

These mice carry a spontaneous mutation at the Slc45a2 locus characterized by a reduction of pigmentation in both eye and coat color.

Development

Slc45a2^Uw-dbr was a spontaneous mutation that arose on B10PL(73NS) at N8F34. It was backcrossed to C57BL/6J for 8 generations, then sibling mated heterozygote x wild type or wild type x heterozygote. Embryos were frozen from C57BL/6J females x homozygous males.

Allele

Symbol: Slc45a2^Uw-dbr
Name: underwhite dominant brown
MGI accession ID: MGI:1856227
Generation method: Spontaneous
Marker symbol: Slc45a2
Marker name: solute carrier family 45, member 2
Chromosome: 15
Strain of origin: B10.PL-H2^u/(73NS)Sn
Molecular note: Molecular analysis reveals a G-to-A transition in codon 153, resulting in the substitution of a highly conserved aspartic acid with asparagine (p.D153N). The substitution occurs near the cytoplasmic face of transmembrane domain 4, adjacent to the loop containing the sucrose transporter signature sequence.