The dilute (Myo5ad) coat color mutation of DBA/2J mice is closely associated with the site of integration of an ecotropic murine leukemia provirus. Dilute revertants (Myo5ad+) show a reversion to wild-type coat-color and a loss of most of the ecotropic proviral genome. This DBA/2J strain carries both dilute mutation ((Myo5ad), characteristic of the DBA/2J inbred strain, and the Myo5ad+17J spontaneous revertant mutation that occurred on a DBA/2J mouse.
This strain was cryopreserved in 1983 by crossing heterozygous males (Myo5ad+17J/Myo5ad) to DBA/2J (Myo5ad/Myo5ad) females at generation F132+2N1F2N1.
|Allele Synonym(s)||blue dilution; d; dv; Maltese dilution|
|Gene Symbol and Name||Myo5a, myosin VA|
|Strain of Origin||old mutant of the mouse fancy|
|Molecular Note||This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5ad gene. Reversions of Myo5ad to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.|