Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the red-eyed white spontaneous mutation Mitfmi-rw have some pigmentation around the neck and have small red eyes.
The red-eyed white recessive mutation (MitfMi-rw) arose spontaneously in the CBA/J strain.
|Allele Name||red eyed white|
|Gene Symbol and Name||Mitf, melanogenesis associated transcription factor|
|Strain of Origin||CBA/J|
|General Note||Mitfmi-rw/Mitfmi mice are all white with small or absent eyes; Mitfmi-rw/Mitfmi-sp, fully pigmented except for a white belly spot; and Mitfmi-rw/MitfMi-wh mostly white with tan spots and red eyes (J:13661).|
|Molecular Note||This allele contains a large genomic deletion that begins approximately 6kb upstream of the melanocyte-specific 5' end and includes the heart-specific 5'end encompassing exons 1H,1D and 1B.|