These mice carry a spontaneous mutation at the Mitf locus characterized by small, red eyes and a white coat with pigmented spots around neck or tail.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Mitf | melanogenesis associated transcription factor |
Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the red-eyed white spontaneous mutation Mitfmi-rw have some pigmentation around the neck and have small red eyes.
The red-eyed white recessive mutation (MitfMi-rw) arose spontaneously in the CBA/J strain.
Allele Name | red eyed white |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Mitf, melanogenesis associated transcription factor |
Gene Synonym(s) | |
Strain of Origin | CBA/J |
Chromosome | 6 |
General Note | Mitfmi-rw/Mitfmi mice are all white with small or absent eyes; Mitfmi-rw/Mitfmi-sp, fully pigmented except for a white belly spot; and Mitfmi-rw/MitfMi-wh mostly white with tan spots and red eyes (J:13661). |
Molecular Note | This allele contains a large genomic deletion that begins approximately 6kb upstream of the melanocyte-specific 5' end and includes the heart-specific 5'end encompassing exons 1H,1D and 1B. |
When using the red eyed white mouse strain in a publication, please cite the originating article(s) and include JAX stock #000956 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Mitf<mi-rw> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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