Overview

Also Known As: red eyed white

These mice carry a spontaneous mutation at the Mitf locus characterized by small, red eyes and a white coat with pigmented spots around neck or tail.

Genetic overview

Genetic Background	Generation

Mitf^mi-rw

Allele Type	Gene Symbol	Gene Name
Spontaneous	Mitf	melanogenesis associated transcription factor

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Research Applications

Dermatology Research
Endocrine Deficiency Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Sensorineural Research
Mouse/Human Gene Homologs

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Detailed Description

Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the red-eyed white spontaneous mutation Mitf^mi-rw have some pigmentation around the neck and have small red eyes.

Development

The red-eyed white recessive mutation (Mitf^Mi-rw) arose spontaneously in the CBA/J strain.

Control Suggestions

Wild-type from the colony

Additional Information

Considerations for Choosing Controls

Genetics

Mitf^mi-rw

Allele Symbol: Mitf^mi-rw

Allele Name	red eyed white
Allele Type	Spontaneous
Allele Synonym(s)	red eyed white; Mitf^mi-rw
Gene Symbol and Name	Mitf, melanogenesis associated transcription factor
Gene Synonym(s)	bHLHe32; BCC2; black eyed white; bw; Gsfbcc2; CMM8; Gsfbcc2; WS2; WS2A; MI; gsf bright coat colour 2; microphthalmia; mi; vit; wh; vitiligo; mi; COMMAD
Strain of Origin	CBA/J
Chromosome	6
General Note	Mitf^mi-rw/Mitf^mi mice are all white with small or absent eyes; Mitf^mi-rw/Mitf^mi-sp, fully pigmented except for a white belly spot; and Mitf^mi-rw/Mitf^Mi-wh mostly white with tan spots and red eyes (J:13661).
Molecular Note	This allele contains a large genomic deletion that begins approximately 6kb upstream of the melanocyte-specific 5' end and includes the heart-specific 5'end encompassing exons 1H,1D and 1B.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Mitf^mi-rw related

Dermatology Research
- Color and White Spotting Defects
Endocrine Deficiency Research
- Bone/Bone Marrow Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Neurobiology Research
- Hearing Defects
Sensorineural Research
- Eye Defects
- Hearing Defects
Mouse/Human Gene Homologs
- Waardenburg syndrome, type IIA

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Mitf^mi-rw/Mitf^mi-rw
involves: CBA/J

integument phenotype

abnormal coat/hair pigmentation
- Background Sensitivity - mice are predominantly white often with pigmentation around the neck or head, sometimes on the belly

pigmentation phenotype

abnormal coat/hair pigmentation
- Background Sensitivity - mice are predominantly white often with pigmentation around the neck or head, sometimes on the belly

abnormal eye pigmentation

decreased eye pigmentation
- eyes appear red

vision/eye phenotype

abnormal eye pigmentation

abnormal eye size

decreased eye pigmentation
- eyes appear red

microphthalmia

References

Additional References

Hodgkinson CA; Moore KJ; Nakayama A; Steingrimsson E; Copeland NG; Jenkins NA; Arnheiter H. 1993. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74(2):395-404PubMed: 8343963 MGI: J:13562
Tachibana M; Perez-Jurado LA; Nakayama A; Hodgkinson CA; Li X; Schneider M; Miki T; Fex J; Francke U; Arnheiter H. 1994. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3. Hum Mol Genet 3(4):553-7PubMed: 8069297 MGI: J:17853
Steingrimsson E; Moore KJ; Lamoreux ML; Ferre-D'Amare AR; Burley SK; Zimring DC; Skow LC; Hodgkinson CA; Arnheiter H; Copeland NG; Jenkins NA. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments] Nat Genet 8(3):256-63PubMed: 7874168 MGI: J:21366
Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20PubMed: 7852195 MGI: J:21682
Deol MS. 1967. The neural crest and the acoustic ganglion. J Embryol Exp Morphol 17(3):533-41PubMed: 6049665 MGI: J:5048
Raisz LG; Simmons HA; Gworek SC; Eilon G. 1977. Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators. J Exp Med 145(4):857-65PubMed: 870607 MGI: J:5804

Additional - Mitf^mi-rw related

Technical Support

Contact Technical Support

Genotyping Protocols
- Genotyping resources and troubleshooting
Citation
When using the red eyed white mouse strain in a publication, please cite the originating article(s) and include JAX stock #000956 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Heterozygous for Mitf<mi-rw>

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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Also Known As: red eyed white

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Mitfmi-rw

Allele Symbol: Mitfmi-rw

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Mitfmi-rw related

Mammalian Phenotype Terms by Genotype

Genotype: Mitfmi-rw/Mitfmi-rwinvolves: CBA/J

integument phenotype

pigmentation phenotype

vision/eye phenotype

References

Additional References

Additional - Mitfmi-rw related

Genotyping Protocols

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Mitf^mi-rw

Allele Symbol: Mitf^mi-rw

Genotype: Mitf^mi-rw related

Genotype: Mitf^mi-rw/Mitf^mi-rw
involves: CBA/J

Additional - Mitf^mi-rw related