CAROLI was derived from wild mice trapped in Thailand. This wild derived mouse strain is genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and is a valuable tool for sequence comparison, evolution and systematics research.
Read More +CAROLI was derived from wild mice trapped in Thailand and is from the species Mus caroli, which is distantly related to laboratory mice and does not breed with laboratory mice. These mice are characterized by black feet. This wild derived mouse strain is genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and is a valuable tool for sequence comparison, evolution and systematics research.
CAROLI was derived from wild mice trapped by JT Marshall in Chon Buri, Thailand. Mice were sent to both M. Potter (NCI) and Verne Chapman (Roswell Park Memorial Institute). Potter sent mice to EM Eicher at The Jackson Laboratory in 1994. This strain is maintained at The Jackson Laboratory via closed colony breeding and, when possible, sibling breeding. Mus caroli is distantly related to laboratory mice and does not breed with laboratory mice.
Allele Name | b-3 variant |
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Allele Type | Not Applicable |
Allele Synonym(s) | Ahb-3 |
Gene Symbol and Name | Ahr, aryl-hydrocarbon receptor |
Gene Synonym(s) | |
Strain of Origin | M. spretus |
Chromosome | 12 |
General Note | Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains |
Molecular Note | This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele. |
Only approximately 50% of matings produce. Use nesting material, preferably nesting cups which help maintain humidity. CAROLI does not breed with common laboratory mice.
When using the CAROLI/EiJ mouse strain in a publication, please include JAX stock #000926 in your Materials and Methods section.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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