CAROLI/EiJ

Stock number: 000926
Research areas: Metabolism Research, Research Tools

Description

CAROLI was derived from wild mice trapped in Thailand. This wild derived mouse strain is genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and is a valuable tool for sequence comparison, evolution and systematics research.

Detailed description

CAROLI was derived from wild mice trapped in Thailand and is from the species Mus caroli, which is distantly related to laboratory mice and does not breed with laboratory mice. These mice are characterized by black feet. This wild derived mouse strain is genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and is a valuable tool for sequence comparison, evolution and systematics research.

Development

CAROLI was derived from wild mice trapped by JT Marshall in Chon Buri, Thailand. Mice were sent to both M. Potter (NCI) and Verne Chapman (Roswell Park Memorial Institute). Potter sent mice to EM Eicher at The Jackson Laboratory in 1994. This strain is maintained at The Jackson Laboratory via closed colony breeding and, when possible, sibling breeding. Mus caroli is distantly related to laboratory mice and does not breed with laboratory mice.

Allele

Symbol: Ahr^b-3
Name: b-3 variant
MGI accession ID: MGI:2667538
Generation method: Not Applicable
Synonyms: Ah^b-3
Marker symbol: Ahr
Marker name: aryl-hydrocarbon receptor
Marker synonyms: Ah; Ahh; Ahre; bHLHe76; dioxin receptor; In; RP85
Chromosome: 12
Strain of origin: M. spretus
Molecular note: This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele.
General note:

Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains