STOCK In(4)32Rk/J

Stock number: 000897
Product name: In32Rk
Research areas: Research Tools

Development

In(4)32Rk was induced by treatment of a male M. m. Poschiavinus, line POSP, with 0.5 mg/kg TEM and this was bred to C57BL/6J. No further details on strain pedigree are available. This inversion has breakpoints in cytoband 4C2 and 4E3. Roderick reported an anaphase bridge frequency of 0.21 and few, small lumpy telophase bridges. This inversion causes homozygous lethality so it must be maintained from heterozygotes and has been maintained in repulsion with the visible recessive Tyrp1^b. The cryopreserved embryos were generated from the intercross of In(4)28Rk +/+ Tyrp1^b repulsion heterozygotes with either Tyrp1^b homozygotes or another In(4)28Rk +/+ Tyrp1^b repulsion heterozygote. No molecular genotyping assay is available for this inversion. Researchers will be provided the cryorecovered mice and are encouraged to karyotype the mice received. A protocol for karyotyping can be found at the Cytogenetic Models Resource.

Allele

Symbol: In(4)32Rk
Name: inversion, Chr 4, Roderick 32
MGI accession ID: MGI:3789975
Generation method: Chemically induced (other)
Synonyms: In32Rk
Marker symbol: In(4)32Rk
Marker name: inversion, Chr 4, Roderick 32
Marker synonyms: In32Rk
Chromosome: 4
Strain of origin: M. m. domesticus poschiavinus
Molecular note: This inversion was induced with triethylene melamine and the breakpoints are in 4C2 and 4E2.