STOCK In(4)28Rk/J

Stock number: 000877
Product name: In28Rk
Research areas: Research Tools

Development

In(4)28Rk was induced by treatment of a male M. m. Poschiavinus (from a cross of lines POSA x POSD) with 0.3 mg/kg TEM and this was bred to C57BL/6J. No further details on strain pedigree are available. This inversion has breakpoints in cytoband C2 and D3. Roderick reported an anaphase bridge frequency of 0.559 and many medium-length lumpy telophase bridges. This inversion causes homozygous lethality so it must be maintained from heterozygotes. The cryopreserved embryos were generated from the intercross of In(4)28Rk +/+ Tyrp1^b repulsion heterozygotes with either Tyrp1^b homozygotes or another In(4)28Rk +/+ Tyrp1^b repulsion heterozygote. No molecular genotyping assay is available for this inversion. Researchers will be provided the cryorecovered mice and are encouraged to karyotype the mice received. A protocol for karyotyping can be found at the Cytogenetic Models Resource.

Allele

Symbol: In(4)28Rk
Name: inversion, Chr 4, Roderick 28
MGI accession ID: MGI:3789965
Generation method: Chemically induced (other)
Synonyms: In28Rk
Marker symbol: In(4)28Rk
Marker name: inversion, Chr 4, Roderick 28
Marker synonyms: In28Rk
Chromosome: 4
Strain of origin: M. m. domesticus poschiavinus
Molecular note: This inversion was induced with triethylene melamine and the breakpoints are in 4C2 and 4D3.