|Allele Name||retinal degeneration 3|
|Allele Synonym(s)||retinal degeneration 3; Rd3rd3|
|Gene Symbol and Name||Rd3, retinal degeneration 3|
|Gene Synonym(s)||rd-3; rd-3; 3322402L07Rik; RIKEN cDNA 3322402L07 gene; LCA12; C1orf36; 3322402L07Rik; rd3; rd3|
|Strain of Origin||RBF/DnJ|
|General Note||This mutation causes retinal degeneration. In homozygous mutant mice, development proceeds normally through the second postnatal week. Thereafter, photoreceptor and outer nuclear layers begin to degenerate, and by 8 weeks, no photoreceptor cells remain. Changes in electroretinograms parallel the histologic changes. As of 1998 this is the only type of retinal degeneration reported in mice in which the photoreceptors are initially normal (J:4367).|
|Molecular Note||A C to T substitution in Rd3 results in a stop codon after residue 106. The truncated protein is initially expressed in in vitro assays but is degraded.|
|Allele Name||inversion, Chr 5, Roderick 30|
|Allele Type||Chemically induced (other)|
|Allele Synonym(s)||inversion, Chr 5, Roderick 30; In(5)30Rk|
|Gene Symbol and Name||In(5)30Rk, inversion, Chr 5, Roderick 30|
|Strain of Origin||M. m. domesticus poschiavinus|
|Molecular Note||This inversion was induced with triethylene melamine and the breakpoints are in 5A2 and 5E2.|
When using the STOCK In(5)30Rk/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000852 in your Materials and Methods section.
|Homozygous for In(5)30Rk, 1 pair minimum|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
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