Overview

Test matings failed to produce Pgm2^a-m1Ehs homozygotes, indicating that this is a recessive embryonic lethal mutation. No abnormal phenotype has been reported in the heterozygote.

Genetic overview

Genetic Background	Generation

Marker(s)

	Marker Symbol	Marker Name
	Pgm2	phosphoglucomutase 2

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Research Applications

Metabolism Research

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Detailed Description

Test matings failed to produce Pgm2^a-m1Ehs homozygotes, indicating that this is a recessive embryonic lethal mutation. No abnormal phenotype has been reported in the heterozygote.

Development

In 2018 the gene symbol Pgm1 was replaced with Pgm2 to be more consistent with human gene nomenclature. The recessive lethal Pgm2^b-m1Ehs allele was induced by triethylenemelamine treatment of a DBA/2J (Pgm2^b) male, which was then crossed to a C57BL/6J (Pgm2^a) female (Soares 1979). This mutation was imported from Dr. E. R. Soares into the laboratory of Dr. Eva Eicher at The Jackson Laboratory in 1979 and was maintained by breeding to C57BL/6J and C3H/HeJ (Pgm2^c) in alternating generations. A Pgm2^b-m1Ehs/Pgm2^a male was imported and mated to a C3H/HeJ female, then the Pgm2^b-m1Ehs/Pgm2^c offspring were mated to C57BL/6J and their Pgm2^b-m1Ehs/Pgm2^a offspring were bred to C57BL/6J. Compound heterozygotes were screened by cellulose acetate gel electrophoresis to determine genotype. This system of breeding continued until 1983 when embryos were generated for cryopreservation by breeding Pgm2^c/Pgm2^b-m1Ehs males with C57BL/6J females. The cryorecovered pups will be a mix of Pgm2^b-m1Ehs/Pgm2^a and Pgm2^a/Pgm2^c. To continue the line, the Pgm2^b-m1Ehs/Pgm2^a animals should be bred to C3H/HeJ (Pgm2^c) and the Pgm2^b-m1Ehs/Pgm2^c offspring should then be bred to C57BL/6J.

Genetics

Pgm2

Marker Symbol: Pgm2

Marker Synonym(s)
Chromosome(s)	5

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Metabolism Research

Mammalian Phenotype Terms by Genotype

References

Additional - Pgm2 related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Citation
When using the B6BALB Pgm2^c/Pgm2^a/J or Pgm2^c/Pgm2^b/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000829 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous for Pgm1<b-m1Ehs>

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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