AKR/J-Foxn1^nu-str/J

Stock number: 000820
Product name: nude streaker
Research areas: Dermatology Research, Immunology, Inflammation and Autoimmunity Research

Detailed description

Mice homozygous for the streaker spontaneous have a phenotype that is very similar to nude mice. Homozygosity prevents the development of T cell lymphomas seen in AKR mice.

Development

The nude streaker mutation arose spontaneously in 1974 on the AKR/J inbred background in the laboratory of Dr. Eva Eicher at The Jackson Laboratory. It has been maintained on the AKR/J background, using primarily the backcross-intercross breeding scheme.

Allele

Symbol: Foxn1^nu-str
Name: nude streaker
MGI accession ID: MGI:1856109
Generation method: Spontaneous
Synonyms: nu^str
Marker symbol: Foxn1
Marker name: forkhead box N1
Marker synonyms: D11Bhm185e; FKHL20; Hfh11; Rnu; RONU; TIDAND; TLIND; whn
Chromosome: 11
Strain of origin: AKR/J
Molecular note: A spontaneous mutation to nude called streaker arose in the AKR/J strain in 1974 at The Jackson Laboratory. An allele test confirmed that streaker is an allele of nude.