WB.Cg-Hba^th-J/J

Stock number: 000802
Product name: alpha thalassemia Jackson
Research areas: Developmental Biology Research, Hematological Research

Detailed description

These mice carry an triethylenemelamine-induced mutation at the Hba locus characterized by microcytosis, erythrocytosis, low blood hemoglobin levels, and a low body weight.

Development

The alpha thalassemia Jackson mutation was identified in the progeny of a C57BL/6J female bred to a triethyllenemlamine treated male, but the genetic origins of that male are not defined in the literature. This mutation was backcrossed onto WB/ReJ via the continuous backcrossing of heterozygotes to an inbred at each generation. In 1988 embryos were cryopreserved from wild-type females bred to heterozygous males at generation N32.

Allele

Symbol: Hba^th-J
Name: alpha thalassemia Jackson
MGI accession ID: MGI:1858115
Generation method: Chemically induced (other)
Marker symbol: Hba
Marker name: hemoglobin alpha chain complex
Chromosome: 11
Strain of origin: C57BL/6J x Triethyllenemelamine-treated male
Molecular note: This mutation was shown to be a deletion that included the Hba-x, Hba-a1 and Hba-a2 genes (J:32654). The Mpg, Rhbdf1 and Phg genes are also included in the deletion region (J:29665).
General note: The mutation was induced in a male mouse by triethyllenemelamine.