These mice carry an triethylenemelamine-induced mutation at the Hba locus characterized by microcytosis, erythrocytosis, low blood hemoglobin levels, and a low body weight.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Chemically induced (other) | Hba | hemoglobin alpha chain complex |
These mice carry an triethylenemelamine-induced mutation at the Hba locus characterized by microcytosis, erythrocytosis, low blood hemoglobin levels, and a low body weight.
The alpha thalassemia Jackson mutation was identified in the progeny of a C57BL/6J female bred to a triethyllenemlamine treated male, but the genetic origins of that male are not defined in the literature. This mutation was backcrossed onto WB/ReJ via the continuous backcrossing of heterozygotes to an inbred at each generation. In 1988 embryos were cryopreserved from wild-type females bred to heterozygous males at generation N32.
Allele Name | alpha thalassemia Jackson |
---|---|
Allele Type | Chemically induced (other) |
Allele Synonym(s) | alphaMD |
Gene Symbol and Name | Hba, hemoglobin alpha chain complex |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J x Triethyllenemelamine-treated male |
Chromosome | 11 |
General Note | The mutation was induced in a male mouse by triethyllenemelamine. |
Molecular Note | This mutation was shown to be a deletion that included the Hba-x, Hba-a1 and Hba-a2 genes (J:32654). The Mpg, Rhbdf1 and Phg genes are also included in the deletion region (J:29665). |
When using the alpha thalassemia Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #000802 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Hba<thJ> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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