This strain is homozygous for the retinal degeneration allele Pde6brd1.
Mice homozygous for the Faslgld mutation display lymphadenopathy and systemic autoimmunity similar to that in Fasllpr homozygous mice. There is significant enlargement of all lymph nodes to 50 times the control weight by 20 weeks of age. Homozygotes also have an enlarged spleen, greatly increased numbers of T, B, and null lymphocytes and develop immune complex glomerulonephrosis. Onset of symptoms is dependent on genetic background with the C3H/HeJ strain having the earliest onset exhibiting glomerulonephritis by 22 weeks.
|Allele Name||generalized lymphoproliferative disease|
|Allele Synonym(s)||CD95-; FasL-; gld; Tnfsf6gld|
|Gene Symbol and Name||Fasl, Fas ligand (TNF superfamily, member 6)|
|Strain of Origin||C3H/HeJ|
|Molecular Note||A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 (p.F273L) in the extracellular region of the encoded protein.|
When using the generalized lymphoproliferative disease mouse strain in a publication, please cite the originating article(s) and include JAX stock #000784 in your Materials and Methods section.