These mice carry a spontaneous mutation at the Fasl locus characterized by lymphadenopathy and systemic autoimmunity.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Fasl | Fas ligand (TNF superfamily, member 6) |
This strain is homozygous for the retinal degeneration allele Pde6brd1.
Mice homozygous for the Faslgld mutation display lymphadenopathy and systemic autoimmunity similar to that in Fasllpr homozygous mice. There is significant enlargement of all lymph nodes to 50 times the control weight by 20 weeks of age. Homozygotes also have an enlarged spleen, greatly increased numbers of T, B, and null lymphocytes and develop immune complex glomerulonephrosis. Onset of symptoms is dependent on genetic background with the C3H/HeJ strain having the earliest onset exhibiting glomerulonephritis by 22 weeks.
Allele Name | generalized lymphoproliferative disease |
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Allele Type | Spontaneous |
Allele Synonym(s) | CD95-; FasL-; gld; Tnfsf6gld |
Gene Symbol and Name | Fasl, Fas ligand (TNF superfamily, member 6) |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 1 |
Molecular Note | A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 (p.F273L) in the extracellular region of the encoded protein. |
When using the generalized lymphoproliferative disease mouse strain in a publication, please cite the originating article(s) and include JAX stock #000784 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Fasl<gld> |
Frozen Mouse Embryo | C3H/HeJ-Fasl<gld>/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Fasl<gld>/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Fasl<gld>/J | $3373.50 |
Frozen Mouse Embryo | C3H/HeJ-Fasl<gld>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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