Similar to the original bouncy allele (bc), mice homozygous for bouncy 3J (bc3J) exhibit moderate tremors, an impaired (bouncy) gait, male infertility and small body size. Some homozygous mice die before weaning; mice that survive have a normal lifespan. This mutant mouse strain may be useful in neurological studies of motor coordination. The Clcc1m1J spontaneous mutation, which causes increased sensitivity to endoplasmic reticulum stress in the cerebellum, was identified in C3H/HeSnJ (Jia et al., 2015) and has been found homozygous in all C3H/HeSn strains assessed at The Jackson Laboratory, including this mutant subline, which is homozygous for Clcc1m1J.

Similar to the original bouncy allele (bc), mice homozygous for bouncy 3J (bc3J) exhibit moderate tremors, an impaired (bouncy) gait, male infertility and small body size. This mutant mouse strain may be useful in neurological studies of motor coordination.

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