Rhino mice have spleen cells with a defective response to T-dependent antigens and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which occur in young mice and increase with age. These mice have increased numbers of Thy1 positive epidermal dendritic cells. Like homozygous hairless mice, rhino mice are hairless by 5 weeks and their skin becomes wrinkled and thickened.
|Allele Name||rhino 7 Jackson|
|Gene Symbol and Name||Hr, lysine demethylase and nuclear receptor corepressor|
|Strain of Origin||C57BL/6J-Hbbp|
|Molecular Note||This allele was identified from the results of a noncomplementation test with Hr |