These mice carry a spontaneous mutation at the Pou1f1 locus characterized by severe dwarfing, sterility, and hypothyroidism. The strain also carries the coat color mutation, leaden, as an aid for identifying genotypes.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Pou1f1 | POU domain, class 1, transcription factor 1 |
Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Mlph | melanophilin |
This DW/J congenic strain is wildtype for both the leaden (Mlph+) and dwarf (Pou1f1+) mutations and thus serves as a control strain for DW/J Mlphln Pou1f1dw/J (Stock No. 000643).
(Pou1f1 was formerly Pit1)
This control strain for DW/J was made to provide compatible hosts for ovarian transplantation. In 1966 the DW/J strain was sent to The Jackson Laboratory Animal Resources Mutant Stocks department. At this time the stock was maintained by tested sibling matings. In order to use ovarian transplants a compatible host and color coded strain was started by crossing a DW/J mouse to a C3H/HeJ .The offspring of this cross, a non leaden and non dwarf mouse, was crossed back to strain DW/J each generation to N10. At generation N11 the pairs were tested by breeding to be non-carriers of leaden and dwarf making this control line Mlph+ and Pit1+. It was cryopreserved in 1992 my mating the homozygous wild type males and females at N11 F20.
When using the dwarf mouse strain in a publication, please cite the originating article(s) and include JAX stock #000681 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Wild=type for Mlph<+>,Wild=type for Pou1f1<+> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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