JAX Mouse Strain Datasheet - 000651

BALB/cJ

Stock No:: 000651

Inbred Strain

Readily Available

Overview

Also Known As: BALBc, C

BALB/cJ is a commonly used inbred. Key traits include a susceptibility to developing the demyelinating disease upon infection with Theiler's murine encephalomyelitis virus. The BALB/cJ substrain is susceptible to Listeria, all species of Leishmania, and several species of Trypanosoma, but is resistant to experimental allergic orchitis (EAO).

Genetic overview

Genetic Background	Generation
	F243 (05-AUG-14)

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Research Applications

Cancer Research
Cardiovascular Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Research Tools
Sensorineural Research

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Details

Detailed Description

BALB/c mice are particularly well known for the production of plasmacytomas following injection with mineral oil forming the basis for the production of monoclonal antibodies. Although not all BALB/c substrains have been examined for plasmacytoma induction, substrains derived from the Andervont (An) lineage (which includes BALB/cByJ) typically are susceptible, while those descended from BALB/cJ are resistant (see: Potter M, 1985). Mammary tumor incidence is normally low but infection with mammary tumor virus by fostering to MMTV⁺ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life including reticular neoplasms, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains. This strain was found to be susceptible to infection by Listeria monocytogenes, with a 3 day median time to death in females (Cheers and McKenzie, 1978).

White et al. reported a variation in thioglycolate medium-induced peritoneal leukocyte recruitment in 4 analyzed strains. The response of total leukocyte recruitment, from greatest to least, was C57BL/6J>BALB/c>CD1>129X1/SvJ. Variations were also found in the timeline of response and cell types most impacted.

BALB/c mice immunized with PLP_180-199 develop an atypical form of experimental autoimmune encephalomyelitis (EAE) in which susceptibility is determined by location. In the spinal cord 60-70% mice develop pathological lesions and in the brain and cerebellum 100% of mice develop sever lesions.

Dorso-ventral vaginal septa is observed in some BALB/cJ females, and may contribute to non-productive females in this strain. (Cunliffe-Beamer T, Lab Anim Sci, 1976)

Development

This is a substrain of BALB (Bagg's albino) derived initially from the BALB strain maintained by MacDowell at Cold Spring Harbor, eventually sent to G.D. Snell at the University of Texas and brought by Snell to the Jackson Laboratory in 1932 at generation F26. Three branches from Snell's BALB/c were separated during the period 1937-1939, Andervont (BALB/cAn), Scott (BALB/cSc), and Green (BALB/cGn). The lineage from BALB/cSc eventually became BALB/cJ in 1941 at generation F41.

Selected References

Bentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A 67(1):377-84. PubMed: 4318784 MGI: J:24803
Cheers C; McKenzie IF. 1978. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun 19(3):755-62. PubMed: 305895 MGI: J:5965
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8. PubMed: 4322934 MGI: J:24674
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163. PubMed: 28784771 MGI: J:244295

View All References

Genetics

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	Cdh23^753A; mdfw
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	4930542A03Rik; 4930542A03Rik; CDHR23; PITA5; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; ahl; bob; bob; bobby; bus; bustling; mdfw; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf112; nmf181; nmf181; nmf252; nmf252; sals; sals; salsa; v; waltzer
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Hld

Allele Symbol: Hld

Allele Name	hippocampal lamination defect
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Hld, hippocampal lamination defect
Gene Synonym(s)
Strain of Origin	BALB/cJ
Chromosome	UN

Micrlⁿ

Allele Symbol: Micrlⁿ

Allele Name	non-responder
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Micrl, microwave induced increase in complement receptor B cells
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	The following inbred strains are homozygous for the recessive QTL, Micrl, and do not respond to microwave exposure by increasing splenic C3 receptor-bearing B cells: A/J, BALB/cJ, C3HeB/FeN, C57BL/6J, C57BL/10J (inferred from the response of two congenic lines "B10.BR", "B10.D2", "B10.D2"),C58/J, AK.B6-H2^b, and B6.AK-H2^k. These recombinant inbred strains are also non-responding: BXH2/Ty, BXH6/Ty, BXH7/Ty, BXH12/Ty, and BXH14/Ty.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cancer Research
- Increased Tumor Incidence
  - Mammary Gland Tumors
  - Mammary Gland Tumors: late onset
Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Relatively Resistant
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimental allergic encephalomyelitis (EAE)
- Inflammation
Neurobiology Research
- Behavioral and Learning Defects
  - high anxiety
- Neurodevelopmental Defects
  - callosal agenesis, incomplete penetrance
Research Tools
- Cancer Research
  - monoclonal antibodies, myeloma and hybridoma production
- General Purpose
- Infectious Disease
  - Anthrax
  - Salmonella
  - Tuberculosis (TB)

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Mammalian Phenotype Terms by Genotype

Genotype: Hld/Hld
either: BALB/cByJ or BALB/cJ

nervous system phenotype

abnormal dendrite morphology
- abnormally positioned by being late-generated
- cell bodies are located below the intrapyramidal mossy fiber layer

abnormal hippocampal mossy fiber morphology

abnormal hippocampus CA3 region morphology
- there is abnormal lamination of this cell layer resulting in superficial early generated neurons and deep late-generated neurons

abnormal hippocampus layer morphology
- Background Sensitivity - the anomaly is also seen in BALB/cByJ, F1 mice involving BALB sublines noted, and some CXB RI lines; C57BL/6J is considered wild-type for this feature
- this is secondary to a defect in neuronal migration

abnormal hippocampus morphology

abnormal neuronal migration

ectopic hippocampus pyramidal cells
- located below the intrapyramidal layer; some of the ectopic cells have short, fine-caliber dendritic branches arising near the points of contact of the intrapyramidal mossy fibers

cellular phenotype

abnormal neuronal migration

Phenotype Information

Body Weight Information - JAX^® Mice Strain BALB/cJ (000651)

References

Bentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A 67(1):377-84. PubMed: 4318784 MGI: J:24803
Cheers C; McKenzie IF. 1978. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun 19(3):755-62. PubMed: 305895 MGI: J:5965
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8. PubMed: 4322934 MGI: J:24674
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163. PubMed: 28784771 MGI: J:244295

Additional References

Bell BA; Kaul C; Bonilha VL; Rayborn ME; Shadrach K; Hollyfield JG. 2015. The BALB/c mouse: Effect of standard vivarium lighting on retinal pathology during aging. Exp Eye Res 135:192-205. PubMed: 25895728 MGI: J:230336
Belzung C; Griebel G. 2001. Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res 125(1-2):141-9. PubMed: 11682105 MGI: J:72742
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. PubMed: 11853768 MGI: J:75095
Cunliffe-Beamer TL; Feldman DB. 1976. Vaginal septa in mice: incidence, inheritance, and effect on reproductive, performance. Lab Anim Sci 26(6 Pt 1):895-8. PubMed: 1018474 MGI: J:24296
Ebbesen P. 1971. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. J Natl Cancer Inst 47(6):1241-5. PubMed: 4941118 MGI: J:24297
Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. Am J Respir Cell Mol Biol 23(4):537-45. PubMed: 11017920 MGI: J:66641
Fairless AH; Dow HC; Toledo MM; Malkus KA; Edelmann M; Li H; Talbot K; Arnold SE; Abel T; Brodkin ES. 2008. Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain Res 1230:211-7. PubMed: 18662677 MGI: J:138841
Fichtner-Feigl S; Fuss IJ; Preiss JC; Strober W; Kitani A. 2005. Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides. J Clin Invest 115(11):3057-71. PubMed: 16239967 MGI: J:145688
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. Elife 4:e05607. PubMed: 26067236 MGI: J:223755
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. PubMed: 14945054 MGI: J:166288
Nowakowski RS. 1984. The mode of inheritance of a defect in lamination in the hippocampus of BALB/c mice. J Neurogenet 1(3):249-58. PubMed: 6536729 MGI: J:7947
Nowakowski RS. 1984. Hippocampal lamination defect = Hld. Mouse News Lett 71:35. MGI: J:13989
Nygaard UC; Aase A; Lovik M. 2005. The allergy adjuvant effect of particles - genetic factors influence antibody and cytokine responses. BMC Immunol 6:11. PubMed: 15967044 MGI: J:149209
Orian JM; Keating P; Downs LL; Hale MW; Jiang X; Pham H; LaFlamme AC. 2014. Deletion of IL-4Ralpha in the BALB/c mouse is associated with altered lesion topography and susceptibility to experimental autoimmune encephalomyelitis. Autoimmunity :1-14. PubMed: 25427822 MGI: J:220802
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. PubMed: 2317166 MGI: J:22615
Panksepp JB; Rodriguez ED; Ryabinin AE. 2017. Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice. Genes Brain Behav 16(3):369-383. PubMed: 27706910 MGI: J:263201
Roberts JE; Watters JW; Ballard JD; Dietrich WF. 1998. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol 29(2):581-91. PubMed: 9720874 MGI: J:49726
Roderick TH; Langley SH; Leiter EH. 1985. Some unusual genetic characteristics of BALB/c and evidence for genetic variation among BALB/c substrains. Curr Top Microbiol Immunol 122:9-18. PubMed: 3899524 MGI: J:24307
Sass B; Peters RL; Kelloff GJ. 1976. Differences in tumor incidence in two substrains of Claude BALB/c (BALB/cfCd) mice, emphasizing renal, mammary, pancreatic, and synovial tumors. Lab Anim Sci 26(5):736-41. PubMed: 185454 MGI: J:24705
Schlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. PubMed: 6980940 MGI: J:6835
Sittig LJ; Jeong C; Tixier E; Davis J; Barrios-Camacho CM; Palmer AA. 2014. Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ. Mamm Genome 25(11-12):564-72. PubMed: 24997021 MGI: J:250048
Sundberg JP; Hanson CA; Roop DR; Brown KS; Bedigian HG. 1991. Myoepitheliomas in inbred laboratory mice. Vet Pathol 28(4):313-23. PubMed: 1719689 MGI: J:22767
Tang X; Orchard SM; Sanford LD. 2002. Home cage activity and behavioral performance in inbred and hybrid mice. Behav Brain Res 136(2):555-69. PubMed: 12429418 MGI: J:80398
Teuscher C; Blankenhorn EP; Hickey WF. 1987. Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains. Cell Immunol 110(2):294-304. PubMed: 2446778 MGI: J:149656
Villarino NF; LeCleir GR; Denny JE; Dearth SP; Harding CL; Sloan SS; Gribble JL; Campagna SR; Wilhelm SW; Schmidt NW. 2016. Composition of the gut microbiota modulates the severity of malaria. Proc Natl Acad Sci U S A 113(8):2235-40. PubMed: 26858424 MGI: J:230422
Wahlsten D. 1989. Deficiency of the corpus callosum: incomplete penetrance and substrain differentiation in BALB/c mice. J Neurogenet 5(1):61-76. PubMed: 2703941 MGI: J:138843
Welkos SL; Keener TJ; Gibbs PH. 1986. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect Immun 51(3):795-800. PubMed: 3081444 MGI: J:8197
Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42. PubMed: 12626335 MGI: J:84265
Zhu W; Gilmour MI. 2009. Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen. Immunogenetics 61(3):199-207. PubMed: 19224206 MGI: J:146790

Additional - Cdh23^ahl related

Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. PubMed: 22952717 MGI: J:191663
Davis RR; Newlander JK; Ling X; Cortopassi GA; Krieg EF; Erway LC. 2001. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hear Res 155(1-2):82-90. PubMed: 11335078 MGI: J:69679
Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). Gene 281(1-2):31-41. PubMed: 11750125 MGI: J:73941
Fetoni AR; Picciotti PM; Paludetti G; Troiani D. 2011. Pathogenesis of presbycusis in animal models: a review. Exp Gerontol 46(6):413-25. PubMed: 21211561 MGI: J:186964
Han F; Yu H; Tian C; Chen HE; Benedict-Alderfer C; Zheng Y; Wang Q; Han X; Zheng QY. 2012. A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. Pharmacogenomics J 12(1):30-44. PubMed: 20644563 MGI: J:174758
Hurd EA; Adams ME; Layman WS; Swiderski DL; Beyer LA; Halsey KE; Benson JM; Gong TW; Dolan DF; Raphael Y; Martin DM. 2011. Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. Hear Res 282(1-2):184-95. PubMed: 21875659 MGI: J:220430
Johnson KR; Erway LC; Cook SA; Willott JF; Zheng QY. 1997. A major gene affecting age-related hearing loss in C57BL/6J mice Hear Res 114(1-2):83-92. PubMed: 9447922 MGI: J:44966
Johnson KR; Longo-Guess C; Gagnon LH; Yu H; Zheng QY. 2008. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics 92(4):219-25. PubMed: 18662770 MGI: J:139223
Johnson KR; Tian C; Gagnon LH; Jiang H; Ding D; Salvi R. 2017. Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains. Sci Rep 7:44450. PubMed: 28287619 MGI: J:241137
Johnson KR; Yu H; Ding D; Jiang H; Gagnon LH; Salvi RJ. 2010. Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice. Hear Res 268(1-2):85-92. PubMed: 20470874 MGI: J:163035
Johnson KR; Zheng QY; Bykhovskaya Y; Spirina O; Fischel-Ghodsian N. 2001. A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. Nat Genet 27(2):191-4. PubMed: 11175788 MGI: J:67312
Johnson KR; Zheng QY; Noben-Trauth K. 2006. Strain background effects and genetic modifiers of hearing in mice. Brain Res 1091(1):79-88. PubMed: 16579977 MGI: J:110459
Johnson KR; Zheng QY; Weston MD; Ptacek LJ; Noben-Trauth K. 2005. The Mass1(frings) mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85(5):582-90. PubMed: 15820310 MGI: J:97534
Kane KL; Longo-Guess CM; Gagnon LH; Ding D; Salvi RJ; Johnson KR. 2012. Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice. Hear Res 283(1-2):80-8. PubMed: 22138310 MGI: J:183757
Keithley EM; Canto C; Zheng QY; Fischel-Ghodsian N; Johnson KR. 2004. Age-related hearing loss and the ahl locus in mice. Hear Res 188(1-2):21-8. PubMed: 14759567 MGI: J:87783
Liu X; Bulgakov OV; Darrow KN; Pawlyk B; Adamian M; Liberman MC; Li T. 2007. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A 104(11):4413-8. PubMed: 17360538 MGI: J:118927
Manji SS; Williams LH; Miller KA; Ooms LM; Bahlo M; Mitchell CA; Dahl HH. 2011. A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. PLoS One 6(3):e17607. PubMed: 21423608 MGI: J:171701
Mathews CE; Leiter EH. 1999. Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. Diabetes 48(11):2189-96. PubMed: 10535453 MGI: J:109893
Miyasaka Y; Suzuki S; Ohshiba Y; Watanabe K; Sagara Y; Yasuda SP; Matsuoka K; Shitara H; Yonekawa H; Kominami R; Kikkawa Y. 2013. Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice. Exp Anim 62(4):333-46. PubMed: 24172198 MGI: J:250509
Murillo-Cuesta S; Rodriguez-de la Rosa L; Contreras J; Celaya AM; Camarero G; Rivera T; Varela-Nieto I. 2015. Transforming growth factor beta1 inhibition protects from noise-induced hearing loss. Front Aging Neurosci 7:32. PubMed: 25852546 MGI: J:242536
Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev 13(3):290-5. PubMed: 12787792 MGI: J:88012
Nagtegaal AP; Rainey RN; van der Pluijm I; Brandt RM; van der Horst GT; Borst JG; Segil N. 2015. Cockayne syndrome group B (csb) and group a (csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. J Neurosci 35(10):4280-6. PubMed: 25762674 MGI: J:219993
Noben-Trauth K; Latoche JR; Neely HR; Bennett B. 2010. Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. PLoS One 5(7):e11459. PubMed: 20628639 MGI: J:163117
Noben-Trauth K; Zheng QY; Johnson KR. 2003. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet 35(1):21-3. PubMed: 12910270 MGI: J:86905
Noben-Trauth K; Zheng QY; Johnson KR; Nishina PM. 1997. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44(3):266-72. PubMed: 9325047 MGI: J:38429
Perrin BJ; Sonnemann KJ; Ervasti JM. 2010. beta-actin and gamma-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. PLoS Genet 6(10):e1001158. PubMed: 20976199 MGI: J:167543
Perrin BJ; Strandjord DM; Narayanan P; Henderson DM; Johnson KR; Ervasti JM. 2013. beta-Actin and Fascin-2 Cooperate to Maintain Stereocilia Length. J Neurosci 33(19):8114-21. PubMed: 23658152 MGI: J:197137
Vazquez AE; Jimenez AM; Martin GK; Luebke AE; Lonsbury-Martin BL. 2004. Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions. Hear Res 194(1-2):87-96. PubMed: 15276680 MGI: J:117746
Watson CJ; Tempel BL. 2013. A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers. Hear Res 304:41-8. PubMed: 23792079 MGI: J:220660
Zhang C; Sun W; Li J; Xiong B; Frye MD; Ding D; Salvi R; Kim MJ; Someya S; Hu BH. 2017. Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. Neuroscience 361:179-191. PubMed: 28818524 MGI: J:249779
Zheng QY; Johnson KR. 2001. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res 154(1-2):45-53. PubMed: 11423214 MGI: J:70964
Zheng QY; Scarborough JD; Zheng Y; Yu H; Choi D; Gillespie PG. 2012. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. Hum Mol Genet 21(11):2588-98. PubMed: 22381527 MGI: J:183898
Zilberstein Y; Liberman MC; Corfas G. 2012. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J Neurosci 32(2):405-10. PubMed: 22238076 MGI: J:179911

Additional - Hld related

Barber RP; Vaughn JE; Wimer RE; Wimer CC. 1974. Genetically-associated variations in the distribution of dentate granule cell synapses upon the pyramidal cell dendrites in mouse hippocampus. J Comp Neurol 156(4):417-34. PubMed: 4137683 MGI: J:5486
Nowakowski RS. 1984. Hippocampal lamination defect = Hld. Mouse News Lett 71:35. MGI: J:13989
Nowakowski RS. 1984. The mode of inheritance of a defect in lamination in the hippocampus of BALB/c mice. J Neurogenet 1(3):249-58. PubMed: 6536729 MGI: J:7947
Nowakowski RS; Davis TL. 1985. Dendritic arbors and dendritic excrescences of abnormally positioned neurons in area CA3c of mice carrying the mutation hippocampal lamination defect. J Comp Neurol 239(3):267-75. PubMed: 4044940 MGI: J:12029
Vaughn JE; Matthews DA; Barber RP; Wimer CC; Wimer RE. 1977. Genetically-associated variations in the development of hippocampal pyramidal neurons may produce differences in mossy fiber connectivity. J Comp Neurol 173(1):41-51. PubMed: 845286 MGI: J:5787

Additional - Micrlⁿ related

Schlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. PubMed: 6980940 MGI: J:6835

Also Known As: BALBc, C

Genetic overview

Research Applications

Base Price

Volume Pricing Available!

Detailed Description

Development

Selected References

Cdh23ahl

Allele Symbol: Cdh23ahl

Hld

Allele Symbol: Hld

Micrln

Allele Symbol: Micrln

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23ahl related

Mammalian Phenotype Terms by Genotype

Genotype: Hld/Hldeither: BALB/cByJ or BALB/cJ

nervous system phenotype

cellular phenotype

Phenotype Information

References

Additional References

Additional - Cdh23ahl related

Additional - Hld related

Additional - Micrln related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Volume Pricing Details

Cryorecovery - Pricing

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Cdh23^ahl

Allele Symbol: Cdh23^ahl

Micrlⁿ

Allele Symbol: Micrlⁿ

Genotype: Cdh23^ahl related

Genotype: Hld/Hld
either: BALB/cByJ or BALB/cJ

Additional - Cdh23^ahl related

Additional - Micrlⁿ related