B6 x B6C3Sn a/A-T(8;16)17H/J

Stock number: 000602
Product name: T17H
Research areas: Research Tools

Development

T(8;16)17H was found in the daughter of CBA/H female x X-irradiated (C3H x 101)F1 male. This daughter was bred to a C57BL/H male (Searle, AG, 1964). This translocation was maintained at The Jackson Laboratory by breeding to B6C3HF1 at each generation prior to crossing it to Stock No. 000510, C3H/HeJ-Pou1f1^dw-J/J.

Allele

Symbol: a
Name: nonagouti
MGI accession ID: MGI:1855937
Generation method: Spontaneous
Marker symbol: a
Marker name: nonagouti
Marker synonyms: agouti; agouti signal protein; AGSW; AGTI; AGTIL; As; Asip; ASP; SHEP9
Chromosome: 2
Strain of origin: old mutant of the mouse fancy
Molecular note: Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats (beta4 retroviral sequence). The host integration site is the same as for a^t-2Gso and A^w-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type.
General note: Insertion of the LV30 retrotransposon without the beta4 retrovirus sequence does not cause the nonagouti phenotype. J:278039

Allele

MGI accession ID: MGI:104011
Marker symbol: T(8;16)17H
Marker name: reciprocal translocation, Chr 8 and 16, Harwell 17
Marker synonyms: T17H
Chromosome: 16