T(8;16)17H was found in the daughter of CBA/H female x X-irradiated (C3H x 101)F1 male. This daughter was bred to a C57BL/H male (Searle, AG, 1964). This translocation was maintained at The Jackson Laboratory by breeding to B6C3HF1 at each generation prior to crossing it to Stock No. 000510, C3H/HeJ-Pou1f1^dw-J/J.

Genetics

a

Allele Symbol: a

Allele Name	nonagouti
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)
Strain of Origin	old mutant of the mouse fancy
Chromosome	2
General Note	Insertion of the LV30 retrotransposon without the beta4 retrovirus sequence does not cause the nonagouti phenotype. J:278039
Molecular Note	Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats (beta4 retroviral sequence). The host integration site is the same as for a^t-2Gso and A^w-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type.

T(8;16)17H

Marker Symbol: T(8;16)17H

Marker Synonym(s)
Chromosome(s)	16

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Research Tools
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Mammalian Phenotype Terms by Genotype

References

Additional - a related

Additional - T(8;16)17H related

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Citation
When using the B6 x B6C3Sn a/A-T(8;16)17H/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000602 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous or Wild-type for T(8;16)17H

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Genetic overview

Marker(s)

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Development

a