Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Itpr3 | inositol 1,4,5-triphosphate receptor 3 |
Marker Symbol | Marker Name | |
---|---|---|
T(1;17)190Ca | reciprocal translocation, Chr 1 and 17, Carter 190 |
Allele Name | tufted |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | tf |
Gene Symbol and Name | Itpr3, inositol 1,4,5-triphosphate receptor 3 |
Gene Synonym(s) | |
Strain of Origin | BTBR |
Chromosome | 17 |
General Note | This allele was recovered from a Harwell testing stock carrying multiple recessive markers in an undefined background. (J:273) |
Molecular Note | Complementation mapping was used to demonstrate that this spontaneous mutation was an allele of Itpr3. Sequencing revealed a 12 bp deletion in Exon23 (Chr17: 27238069, Build 38.1) which codes for amino acids 983-986. This mutation arose early in the history of the BTBR strain (in or soon after 1956) and is not found in 18 other strains (129P2/OlaHsd, 129S1/SvImJ, 129S5/SvEvBrd, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6NJ, CAST/EiJ, CBA/J, DBA/2J, FVB/NJ, LP/J, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, SPRET/EiJ and WSB/EiJ) |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 17 |
When maintaining a live colony, mice can be bred as wildtype x heterozygote for T(1;17)190Ca and for homozygote x heterozygote for tf.
When using the T190Ca mouse strain in a publication, please cite the originating article(s) and include JAX stock #000588 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for T(1;17)190Ca Heterozygous or Wild-type for tf |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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