growth/size/body region phenotype

• increased growth rate
  • mice show faster growth and development, having a fully developed righting reflex response by P2 compared to P6 in C57BL/6 controls, full negative geotaxis response acquired by P4 versus P8, earlier detachment of pinnae, opening of the eyes and incisor eruption, shorter latencies on the homing test suggesting more rapid development social olfactory and cognitive abilities, accelerated acquisition of various reflexes, and greater response to an acoustic stimulus on P12
  (MGI Ref ID J:138605)

• increased body weight
  • mice are heavier than C57BL/6 controls on P4, 6, 8, and 12
  (MGI Ref ID J:138605)

nervous system phenotype

• abnormal brain commissure morphology
  • Probst bundles are present on both sides of the midline in 100% of mice
  (MGI Ref ID J:222265)
  • neocortices are not connected by the corpus callosum, through other forebrain commissures, nor via ectopic forebrain connections
  (MGI Ref ID J:222265)
  • no streamline connections between homologous interhemispheric areas via the anterior or hippocampal commissure are seen
  (MGI Ref ID J:222265)

• absent corpus callosum
  • agenesis of the corpus callosum
  (MGI Ref ID J:222265)

• abnormal neocortex morphology
  • length of the cortex is reduced at P10, the width is reduced at P22
  (MGI Ref ID J:222265)
  • the relative position of V1 and the posterior medial barrel subfield of the neocortex are shifted towards the midline
  (MGI Ref ID J:222265)
  • the third barrel in row C (C3) of the posterior medial barrel subfield of the neocortex is located in a more medial relative position than in controls
  (MGI Ref ID J:222265)
  • V1 area of the neocortex is reduced
  (MGI Ref ID J:222265)
  • the relative size of the posterior medial barrel subfield of the neocortex is reduced at P10 and the relative size of the visual area is reduced at P10 and P22
  (MGI Ref ID J:222265)

• decreased hippocampal commissure size
  • hippocampal commissure is greatly reduced in size and volume
  (MGI Ref ID J:222265)

• abnormal cerebral cortex morphology
  • changes in cortical thickness is not due to an increase in cell number of a specific cortical laminar population or due to increased apoptosis
  (MGI Ref ID J:222265)
  • thickness of V1 cortical area is increased at P7 but not in adults
  (MGI Ref ID J:222265)

• decreased anterior commissure size
  • anterior commissure is reduced in size and volume
  (MGI Ref ID J:222265)

behavior/neurological phenotype

• abnormal social investigation
  • mice show reduced social approach, low reciprocal social interactions and impaired juvenile play
  (MGI Ref ID J:138842)

• abnormal vocalization
  • pups show an usual pattern of calls, emitting high levels of harmonics, two-syllable, and composite calls, but minimal numbers of chevron-shaped syllables, upward, downward, and short calls
  (MGI Ref ID J:138605)

• excessive vocalization
  • pups call more loudly and more frequently when separated from their mothers and siblings
  (MGI Ref ID J:138605)

• impaired social transmission of food preference
  • mice sniff the whiskers and mouth of their demonstrator cage mate less frequently and for shorter periods of time
  (MGI Ref ID J:138842)
  • mice eat less of the food familiarized by interacting with their demonstrator cage mate than of a completely unfamiliar food
  (MGI Ref ID J:138842)

• abnormal allogrooming behavior
  • number of bouts of social grooming, in which one member of the pair grooms the other, is less in 21 day old mice
  (MGI Ref ID J:138842)

• abnormal locomotor activation
  • locomotion and exploratory activity in a novel open field is initially higher, but mice show normal activity levels after habituation
  (MGI Ref ID J:138842)

• decreased anxiety-related response
  • percentage of time spent on the open segments of the elevated zero maze is higher, indicating very low anxiety-like traits
  (MGI Ref ID J:138842)

• increased grooming behavior
  • both juvenile and adult mice exhibit high levels of repetitive self-grooming
  (MGI Ref ID J:138842)