Overview

Also Known As: T190Ca

Genetic overview

Genetic Background	Generation

Itpr3^tf

Allele Type	Gene Symbol	Gene Name
Spontaneous	Itpr3	inositol 1,4,5-triphosphate receptor 3

Marker(s)

	Marker Symbol	Marker Name
	T(1;17)190Ca	reciprocal translocation, Chr 1 and 17, Carter 190

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Research Applications

Research Tools
Dermatology Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Genetics

Itpr3^tf

Allele Symbol: Itpr3^tf

Allele Name	tufted
Allele Type	Spontaneous
Allele Synonym(s)	tufted; Itpr3^tf
Gene Symbol and Name	Itpr3, inositol 1,4,5-triphosphate receptor 3
Gene Synonym(s)	Ip3r3; inositol 1,4,5-triphosphate receptor, type III; Itpr-3; IP3R; IP3R3; IP3R3X; tf; Itpr-3; tf; tufted; Ip3r3; IP3R-3
Strain of Origin	BTBR
Chromosome	17
General Note	This allele was recovered from a Harwell testing stock carrying multiple recessive markers in an undefined background. (J:273)
Molecular Note	Complementation mapping was used to demonstrate that this spontaneous mutation was an allele of Itpr3. Sequencing revealed a 12 bp deletion in Exon23 (Chr17: 27238069, Build 38.1) which codes for amino acids 983-986. This mutation arose early in the history of the BTBR strain (in or soon after 1956) and is not found in 18 other strains (129P2/OlaHsd, 129S1/SvImJ, 129S5/SvEvBrd, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6NJ, CAST/EiJ, CBA/J, DBA/2J, FVB/NJ, LP/J, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, SPRET/EiJ and WSB/EiJ)

T(1;17)190Ca

Marker Symbol: T(1;17)190Ca

Marker Synonym(s)	T190Ca
Chromosome(s)	17

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).

autistic disorder

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Genetics Research

Genotype: Itpr3^tf related

Dermatology Research
- Skin and Hair Texture Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Itpr3^tf/Itpr3^tf
BTBR T<+> Itpr3/J

behavior/neurological phenotype

abnormal allogrooming behavior
- number of bouts of social grooming, in which one member of the pair grooms the other, is less in 21 day old mice

abnormal locomotor activation
- locomotion and exploratory activity in a novel open field is initially higher, but mice show normal activity levels after habituation

abnormal social investigation
- mice show reduced social approach, low reciprocal social interactions and impaired juvenile play

abnormal vocalization
- pups show an usual pattern of calls, emitting high levels of harmonics, two-syllable, and composite calls, but minimal numbers of chevron-shaped syllables, upward, downward, and short calls

decreased anxiety-related response
- percentage of time spent on the open segments of the elevated zero maze is higher, indicating very low anxiety-like traits

excessive vocalization
- pups call more loudly and more frequently when separated from their mothers and siblings

impaired social transmission of food preference
- mice eat less of the food familiarized by interacting with their demonstrator cage mate than of a completely unfamiliar food
- mice sniff the whiskers and mouth of their demonstrator cage mate less frequently and for shorter periods of time

increased grooming behavior
- both juvenile and adult mice exhibit high levels of repetitive self-grooming

growth/size/body region phenotype

increased body weight
- mice are heavier than C57BL/6 controls on P4, 6, 8, and 12

increased growth rate
- mice show faster growth and development, having a fully developed righting reflex response by P2 compared to P6 in C57BL/6 controls, full negative geotaxis response acquired by P4 versus P8, earlier detachment of pinnae, opening of the eyes and incisor eruption, shorter latencies on the homing test suggesting more rapid development social olfactory and cognitive abilities, accelerated acquisition of various reflexes, and greater response to an acoustic stimulus on P12

nervous system phenotype

abnormal brain commissure morphology
- neocortices are not connected by the corpus callosum, through other forebrain commissures, nor via ectopic forebrain connections
- no streamline connections between homologous interhemispheric areas via the anterior or hippocampal commissure are seen
- Probst bundles are present on both sides of the midline in 100% of mice

abnormal cerebral cortex morphology
- changes in cortical thickness is not due to an increase in cell number of a specific cortical laminar population or due to increased apoptosis
- thickness of V1 cortical area is increased at P7 but not in adults

abnormal neocortex morphology
- length of the cortex is reduced at P10, the width is reduced at P22
- the relative position of V1 and the posterior medial barrel subfield of the neocortex are shifted towards the midline
- the relative size of the posterior medial barrel subfield of the neocortex is reduced at P10 and the relative size of the visual area is reduced at P10 and P22
- the third barrel in row C (C3) of the posterior medial barrel subfield of the neocortex is located in a more medial relative position than in controls
- V1 area of the neocortex is reduced

absent corpus callosum
- agenesis of the corpus callosum

decreased anterior commissure size
- anterior commissure is reduced in size and volume

decreased hippocampal commissure size
- hippocampal commissure is greatly reduced in size and volume

References

Additional - Itpr3^tf related

Technical Support

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Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

When maintaining a live colony, mice can be bred as wildtype x heterozygote for T(1;17)190Ca and for homozygote x heterozygote for tf.
- Additional Breeding and Husbandry Support
Citation
When using the T190Ca mouse strain in a publication, please cite the originating article(s) and include JAX stock #000588 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Heterozygous or Wild-type for T(1;17)190Ca Heterozygous or Wild-type for tf

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

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Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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Also Known As: T190Ca

Genetic overview

Marker(s)

Research Applications

Base Price

Itpr3tf

Allele Symbol: Itpr3tf

T(1;17)190Ca

Marker Symbol: T(1;17)190Ca

Disease Terms

Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Itpr3tf related

Mammalian Phenotype Terms by Genotype

Genotype: Itpr3tf/Itpr3tfBTBR T<+> Itpr3/J

behavior/neurological phenotype

growth/size/body region phenotype

nervous system phenotype

References

Additional - Itpr3tf related

Genotyping Protocols

Breeding Considerations

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Itpr3^tf

Allele Symbol: Itpr3^tf

Genotype: Itpr3^tf related

Genotype: Itpr3^tf/Itpr3^tf
BTBR T<+> Itpr3/J

Additional - Itpr3^tf related