JAX Mouse Strain Datasheet - 000588

TF/GnLe-T(1;17)190Ca +/+ Itpr3^tf/J

Stock No:: 000588

Cryo Recovery

Overview

Genetic overview

Genetic Background	Generation

Itpr3^tf

Allele Type	Gene Symbol	Gene Name
Spontaneous	Itpr3	inositol 1,4,5-triphosphate receptor 3

Marker(s)

	Marker Symbol	Marker Name
	T(1;17)190Ca	reciprocal translocation, Chr 1 and 17, Carter 190

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Research Applications

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Details

Genetics

Itpr3^tf

Allele Symbol: Itpr3^tf

Allele Name	tufted
Allele Type	Spontaneous
Allele Synonym(s)	tf
Gene Symbol and Name	Itpr3, inositol 1,4,5-triphosphate receptor 3
Gene Synonym(s)	IP3R; IP3R-3; IP3R3; IP3R3X; Ip3r3; Ip3r3; Itpr-3; Itpr-3; inositol 1,4,5-triphosphate receptor, type III; tf; tf; tufted
Strain of Origin	BTBR
Chromosome	17
General Note	This allele was recovered from a Harwell testing stock carrying multiple recessive markers in an undefined background. (J:273)
Molecular Note	Complementation mapping was used to demonstrate that this spontaneous mutation was an allele of Itpr3. Sequencing revealed a 12 bp deletion in Exon23 (Chr17: 27238069, Build 38.1) which codes for amino acids 983-986. This mutation arose early in the history of the BTBR strain (in or soon after 1956) and is not found in 18 other strains (129P2/OlaHsd, 129S1/SvImJ, 129S5/SvEvBrd, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6NJ, CAST/EiJ, CBA/J, DBA/2J, FVB/NJ, LP/J, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, SPRET/EiJ and WSB/EiJ)

T(1;17)190Ca

Marker Symbol: T(1;17)190Ca

Marker Synonym(s)	T190Ca
Chromosome(s)	17

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Genetics Research

Genotype: Itpr3^tf related

Dermatology Research
- Skin and Hair Texture Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Itpr3^tf/Itpr3^tf
BTBR T⁺ Itpr3^tf/J

behavior/neurological phenotype

abnormal allogrooming behavior
- number of bouts of social grooming, in which one member of the pair grooms the other, is less in 21 day old mice

abnormal locomotor activation
- locomotion and exploratory activity in a novel open field is initially higher, but mice show normal activity levels after habituation

abnormal social investigation
- mice show reduced social approach, low reciprocal social interactions and impaired juvenile play

abnormal vocalization
- pups show an usual pattern of calls, emitting high levels of harmonics, two-syllable, and composite calls, but minimal numbers of chevron-shaped syllables, upward, downward, and short calls

decreased anxiety-related response
- percentage of time spent on the open segments of the elevated zero maze is higher, indicating very low anxiety-like traits

excessive vocalization
- pups call more loudly and more frequently when separated from their mothers and siblings

impaired social transmission of food preference
- mice eat less of the food familiarized by interacting with their demonstrator cage mate than of a completely unfamiliar food
- mice sniff the whiskers and mouth of their demonstrator cage mate less frequently and for shorter periods of time

increased grooming behavior
- both juvenile and adult mice exhibit high levels of repetitive self-grooming

nervous system phenotype

abnormal brain commissure morphology
- Probst bundles are present on both sides of the midline in 100% of mice
- neocortices are not connected by the corpus callosum, through other forebrain commissures, nor via ectopic forebrain connections
- no streamline connections between homologous interhemispheric areas via the anterior or hippocampal commissure are seen

abnormal cerebral cortex morphology
- changes in cortical thickness is not due to an increase in cell number of a specific cortical laminar population or due to increased apoptosis
- thickness of V1 cortical area is increased at P7 but not in adults

abnormal neocortex morphology
- V1 area of the neocortex is reduced
- length of the cortex is reduced at P10, the width is reduced at P22
- the relative position of V1 and the posterior medial barrel subfield of the neocortex are shifted towards the midline
- the relative size of the posterior medial barrel subfield of the neocortex is reduced at P10 and the relative size of the visual area is reduced at P10 and P22
- the third barrel in row C (C3) of the posterior medial barrel subfield of the neocortex is located in a more medial relative position than in controls

absent corpus callosum
- agenesis of the corpus callosum

decreased anterior commissure size
- anterior commissure is reduced in size and volume

decreased hippocampal commissure size
- hippocampal commissure is greatly reduced in size and volume

growth/size/body region phenotype

increased body weight
- mice are heavier than C57BL/6 controls on P4, 6, 8, and 12

increased growth rate
- mice show faster growth and development, having a fully developed righting reflex response by P2 compared to P6 in C57BL/6 controls, full negative geotaxis response acquired by P4 versus P8, earlier detachment of pinnae, opening of the eyes and incisor eruption, shorter latencies on the homing test suggesting more rapid development social olfactory and cognitive abilities, accelerated acquisition of various reflexes, and greater response to an acoustic stimulus on P12

References

Additional - Itpr3^tf related

Amodeo DA; Jones JH; Sweeney JA; Ragozzino ME. 2012. Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors. Behav Brain Res 227(1):64-72. PubMed: 22056750 MGI: J:180186
Amodeo DA; Rivera E; Dunn JT; Ragozzino ME. 2016. M100907 attenuates elevated grooming behavior in the BTBR mouse. Behav Brain Res 313:67-70. PubMed: 27378338 MGI: J:242522
Borthwell RM; Hunsaker MR; Willemsen R; Berman RF. 2012. Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation. Behav Brain Res 233(1):29-34. PubMed: 22561129 MGI: J:190501
Crabbe JC; Cotnam CJ; Cameron AJ; Schlumbohm JP; Rhodes JS; Metten P; Wahlsten D. 2003. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav 2(4):201-13. PubMed: 12953786 MGI: J:104878
De Felice A; Scattoni ML; Ricceri L; Calamandrei G. 2015. Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism. PLoS One 10(3):e0121663. PubMed: 25803479 MGI: J:229572
Defensor EB; Pearson BL; Pobbe RL; Bolivar VJ; Blanchard DC; Blanchard RJ. 2011. A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice. Behav Brain Res 217(2):302-8. PubMed: 21055421 MGI: J:167352
Ellis HT; Tordoff MG; Parker MR. 2012. Itpr3 Is Responsible for the Mouse Tufted (tf) Locus. J Hered :. PubMed: 23100490 MGI: J:188251
Fenlon LR; Liu S; Gobius I; Kurniawan ND; Murphy S; Moldrich RX; Richards LJ. 2015. Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder. Neural Dev 10:10. PubMed: 25879444 MGI: J:222265
Gogolla N; Takesian AE; Feng G; Fagiolini M; Hensch TK. 2014. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron 83(4):894-905. PubMed: 25088363 MGI: J:221545
Han S; Tai C; Jones CJ; Scheuer T; Catterall WA. 2014. Enhancement of inhibitory neurotransmission by GABAA receptors having alpha2,3-subunits ameliorates behavioral deficits in a mouse model of autism. Neuron 81(6):1282-9. PubMed: 24656250 MGI: J:213173
Heo Y; Zhang Y; Gao D; Miller VM; Lawrence DA. 2011. Aberrant immune responses in a mouse with behavioral disorders. PLoS One 6(7):e20912. PubMed: 21799730 MGI: J:174928
Karunakaran S; Manji A; Yan CS; Wu ZJ; Clee SM. 2013. Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake. Physiol Genomics 45(5):191-9. PubMed: 23341217 MGI: J:195220
Klein AD; Ferreira NS; Ben-Dor S; Duan J; Hardy J; Cox TM; Merrill AH Jr; Futerman AH. 2016. Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Cell Rep 16(10):2546-53. PubMed: 27568557 MGI: J:239022
Kusek GK; Wahlsten D; Herron BJ; Bolivar VJ; Flaherty L. 2007. Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav 6(4):359-63. PubMed: 16899052 MGI: J:137289
Langley EA; Krykbaeva M; Blusztajn JK; Mellott TJ. 2014. High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism. Behav Brain Res 278C:210-220. PubMed: 25300468 MGI: J:216969
Lyon MF. 1956. Hereditary hair loss in the tufted mutant of the house mouse J Hered 47:101-3. MGI: J:273
Lyon MF. 1996. An additional type of male sterility and inherited urinary obstruction in mice with the t-haplotype th7. Genet Res 67(3):249-56. PubMed: 8690273 MGI: J:34190
Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. PubMed: 924142 MGI: J:5889
MacPherson P; McGaffigan R; Wahlsten D; Nguyen PV. 2008. Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice. Brain Res 1210:179-88. PubMed: 18417102 MGI: J:136821
McFarlane HG; Kusek GK; Yang M; Phoenix JL; Bolivar VJ; Crawley JN. 2008. Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 7(2):152-63. PubMed: 17559418 MGI: J:138842
Mercier F; Cho Kwon Y; Kodama R. 2011. Meningeal/vascular alterations and loss of extracellular matrix in the neurogenic zone of adult BTBR T+ tf/J mice, animal model for autism. Neurosci Lett 498(3):173-8. PubMed: 21600960 MGI: J:174319
Mercier F; Kwon YC; Douet V. 2012. Hippocampus/amygdala alterations, loss of heparan sulfates, fractones and ventricle wall reduction in adult BTBR T+ tf/J mice, animal model for autism. Neurosci Lett 506(2):208-13. PubMed: 22100909 MGI: J:180372
Meyza K; Nikolaev T; Kondrakiewicz K; Blanchard DC; Blanchard RJ; Knapska E. 2015. Neuronal correlates of asocial behavior in a BTBR T (+) Itpr3(tf)/J mouse model of autism. Front Behav Neurosci 9:199. PubMed: 26300749 MGI: J:243033
Meyza KZ; Blanchard DC; Pearson BL; Pobbe RL; Blanchard RJ. 2012. Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: a strong model of autism. Behav Brain Res 228(2):247-53. PubMed: 22101175 MGI: J:181751
MouseBook^TM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :. MGI: J:169366
Onore CE; Careaga M; Babineau BA; Schwartzer JJ; Berman RF; Ashwood P. 2013. Inflammatory macrophage phenotype in BTBR T+tf/J mice. Front Neurosci 7:158. PubMed: 24062633 MGI: J:241821
Palmer K; Fairfield H; Borgeia S; Curtain M; Hassan MG; Dionne L; Yong Karst S; Coombs H; Bronson RT; Reinholdt LG; Bergstrom DE; Donahue LR; Cox TC; Murray SA. 2016. Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol 415(2):216-27. PubMed: 26234751 MGI: J:223062
Pearson BL; Bettis JK; Meyza KZ; Yamamoto LY; Blanchard DC; Blanchard RJ. 2012. Absence of social conditioned place preference in BTBR T+tf/J mice: relevance for social motivation testing in rodent models of autism. Behav Brain Res 233(1):99-104. PubMed: 22562042 MGI: J:190500
Pearson BL; Pobbe RL; Defensor EB; Oasay L; Bolivar VJ; Blanchard DC; Blanchard RJ. 2011. Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism. Genes Brain Behav 10(2):228-35. PubMed: 21040460 MGI: J:183514
Rutz HL; Rothblat LA. 2012. Intact and impaired executive abilities in the BTBR mouse model of autism. Behav Brain Res 234(1):33-7. PubMed: 22677272 MGI: J:190470
Sato-Miyaoka M; Hisatsune C; Ebisui E; Ogawa N; Takahashi-Iwanaga H; Mikoshiba K. 2012. Regulation of hair shedding by the type 3 IP3 receptor. J Invest Dermatol 132(9):2137-47. PubMed: 22572820 MGI: J:188252
Scattoni ML; Gandhy SU; Ricceri L; Crawley JN. 2008. Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS One 3(8):e3067. PubMed: 18728777 MGI: J:138605
Scattoni ML; Ricceri L; Crawley JN. 2011. Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters. Genes Brain Behav 10(1):44-56. PubMed: 20618443 MGI: J:183525
Silver LM; Cisek L; Jackson C; Lukralle D. 1985. A new spontaneous mutation at the tufted locus within a mouse t haplotype. Genet Res 45(1):107-12. PubMed: 3996911 MGI: J:7861
Silverman JL; Smith DG; Rizzo SJ; Karras MN; Turner SM; Tolu SS; Bryce DK; Smith DL; Fonseca K; Ring RH; Crawley JN. 2012. Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism. Sci Transl Med 4(131):131ra51. PubMed: 22539775 MGI: J:183984
Silverman JL; Yang M; Turner SM; Katz AM; Bell DB; Koenig JI; Crawley JN. 2010. Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism. Neuroscience 171(4):1197-208. PubMed: 20888890 MGI: J:170182
Tordoff MG; Ellis HT. 2013. Taste dysfunction in BTBR mice due to a mutation of Itpr3, the inositol triphosphate receptor 3 gene. Physiol Genomics 45(18):834-55. PubMed: 23859941 MGI: J:201643
Wei H; Ma Y; Liu J; Ding C; Hu F; Yu L. 2016. Proteomic analysis of cortical brain tissue from the BTBR mouse model of autism: Evidence for changes in STOP and myelin-related proteins. Neuroscience 312:26-34. PubMed: 26562433 MGI: J:237567
Wohr M. 2015. Effect of social odor context on the emission of isolation-induced ultrasonic vocalizations in the BTBR T+tf/J mouse model for autism. Front Neurosci 9:73. PubMed: 25852455 MGI: J:242540
Wohr M; Roullet FI; Crawley JN. 2011. Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism. Genes Brain Behav 10(1):35-43. PubMed: 20345893 MGI: J:183527
Yang M; Clarke AM; Crawley JN. 2009. Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. Eur J Neurosci 29(8):1663-77. PubMed: 19419429 MGI: J:148483
Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. PubMed: 21595826 MGI: J:185685

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Cryorecovery - Pricing

Service	Genotype	Price
	Heterozygous or Wild-type for T(1;17)190Ca Heterozygous or Wild-type for tf

Progeny testing is not required

The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks.

The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Genetic overview

Marker(s)

Research Applications

Base Price

Itpr3tf

Allele Symbol: Itpr3tf

T(1;17)190Ca

Marker Symbol: T(1;17)190Ca

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Itpr3tf related

Mammalian Phenotype Terms by Genotype

Genotype: Itpr3tf/Itpr3tfBTBR T+ Itpr3tf/J

behavior/neurological phenotype

nervous system phenotype

growth/size/body region phenotype

References

Additional - Itpr3tf related

Genotyping Protocols

Breeding Considerations

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Itpr3^tf

Allele Symbol: Itpr3^tf

Genotype: Itpr3^tf related

Genotype: Itpr3^tf/Itpr3^tf
BTBR T⁺ Itpr3^tf/J

Additional - Itpr3^tf related