Mice homozygous for the Jackson circler spontaneous mutation (Sobpjc) show erratic circling behavior which becomes more pronounced with age. Homozygous mutant mice are very active, bobbing up and down and flexing head and trunk ventrally towards the tail and mice can swim. Mice can be identified at weaning by a characteristic flexing behavior when suspended by tail.
|Allele Name||Jackson circler|
|Gene Symbol and Name||Sobp, sine oculis binding protein|
|Strain of Origin||C57BL/6J|
|General Note||Homozygotes show erratic circling behavior which becomes more pronounced with age. They can swim. They are very active, bobbing up and down and flexing head and trunk ventrally towards the tail. Flexing behavior when suspended by tail is diagnostic at weaning age. jc is not allelic with other circling mutants on Chr 10 (J:13506).|
|Molecular Note||A 10 bp deletion is found in exon 6 eliminating nucleotides 1346-1355 of the BC059851 coding sequence. This results in the deletion of 48% of the protein.|
When using the Jackson circler mouse strain in a publication, please cite the originating article(s) and include JAX stock #000563 in your Materials and Methods section.