These mice carry a spontaneous mutation at the Grid2 locus characterized by ataxia.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Grid2 | glutamate receptor, ionotropic, delta 2 |
Glutamate receptor delta2 (Grid2) is selectively expressed in Purkinje cells and plays a crucial role in cerebellar functions. Hotfoot mutations of Grid2 exhibit ataxia and impaired locomotion associated with cerebellar Purkinje cell abnormalities and loss. Ataxia in the hotfoot mouse (Grid2ho-4J) is caused by a deletion in the delta2 receptor gene removing the N-terminal 170 amino acids of the delta2 receptor.
Allele Name | hotfoot 4 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Grid2, glutamate receptor, ionotropic, delta 2 |
Gene Synonym(s) | |
Strain of Origin | DBA/2J |
Chromosome | 6 |
Molecular Note | Exons 5-8 are deleted which results in a 170 amino acid loss in the N-terminal LIVBP-like domain. |
Females homozygous for Grid2ho-4J tend to be poor breeders. Males homozygous for Grid2ho-4J are fertile although males of the original Grid2ho mutation are sterile.
When using the hotfoot 4 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #000548 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Grid2<ho-4J> |
Frozen Mouse Embryo | DBA/2J-Grid2<ho-4J>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | DBA/2J-Grid2<ho-4J>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | DBA/2J-Grid2<ho-4J>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | DBA/2J-Grid2<ho-4J>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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