DBA/2J-Grid2^ho-4J/J

Stock number: 000548
Product name: hotfoot 4 Jackson
Research areas: Neurobiology Research

Description

These mice carry a spontaneous mutation at the Grid2 locus characterized by ataxia.

Detailed description

Glutamate receptor delta2 (Grid2) is selectively expressed in Purkinje cells and plays a crucial role in cerebellar functions. Hotfoot mutations of Grid2 exhibit ataxia and impaired locomotion associated with cerebellar Purkinje cell abnormalities and loss. Ataxia in the hotfoot mouse (Grid2^ho-4J) is caused by a deletion in the delta2 receptor gene removing the N-terminal 170 amino acids of the delta2 receptor.

Allele

Symbol: Grid2^ho-4J
Name: hotfoot 4 Jackson
MGI accession ID: MGI:1856050
Generation method: Spontaneous
Marker symbol: Grid2
Marker name: glutamate receptor, ionotropic, delta 2
Chromosome: 6
Strain of origin: DBA/2J
Molecular note: Exons 5-8 are deleted which results in a 170 amino acid loss in the N-terminal LIVBP-like domain.