Glutamate receptor delta2 (Grid2) is selectively expressed in Purkinje cells and plays a crucial role in cerebellar functions. Hotfoot mutations of Grid2 exhibit ataxia and impaired locomotion associated with cerebellar Purkinje cell abnormalities and loss. Ataxia in the hotfoot mouse (Grid2ho-4J) is caused by a deletion in the delta2 receptor gene removing the N-terminal 170 amino acids of the delta2 receptor.
|Allele Name||hotfoot 4 Jackson|
|Gene Symbol and Name||Grid2, glutamate receptor, ionotropic, delta 2|
|Strain of Origin||DBA/2J|
|Molecular Note||Exons 5-8 are deleted which results in a 170 amino acid loss in the N-terminal LIVBP-like domain.|
Females homozygous for Grid2ho-4J tend to be poor breeders. Males homozygous for Grid2ho-4J are fertile although males of the original Grid2ho mutation are sterile.
When using the hotfoot 4 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #000548 in your Materials and Methods section.