Mice homozygous for the spinner spontaneous (Tmiesr) show the typical head tossing, circling, deafness, and hyperactivity of the shaker and waltzer mutants. Abnormal behavior in homozygous mutant mice can be recognized as early as 7 days. Inner ear abnormalities consist of degeneration of the organ of Corti and spiral ganglion, reduction in size of the stria vascularis of the cochlea, and degeneration of the saccular macula. Both sexes are fertile, but females are not good mothers.
|Gene Symbol and Name||Tmie, transmembrane inner ear|
|Strain of Origin||C57BL/How|
|Molecular Note||This allele comprises a 40 kb deletion that results in the deletion of the 3 end of Prss46 (AK007173), all of Prss50 (Tsp50) and Tmie and the 5 end of Als2cl (Rn49018).|