Mice homozygous for the Jackson waltzer mutation run in circles and shake their heads. The lateral semicircular canal and its cristae are absent, and the sacculus and utriculus may be morphologically abnormal. However, hearing is unaffected. This pheontype is similar to that reported for the Otx1tm1Asim targeted mutation and complementation testing with this targeted mutation showed jv to be an allele of Otx1. (Note that C57BL/6J is homozygous for ahl, the age related hearing loss 1 mutation, which on this strain background causes progressive hearing loss with onset after 10 months of age.) Homozygotes can swim.
The Jackson waltzer (Otx1jv) mutation arose on the C57BL/6J inbred strain at The Jackson Laboratory in 1961. It has been maintained on the same background. Embryos produced by mating heterozygous males to C57BL/6J females were cryopreserved in 1982.
|Allele Name||Jackson waltzer|
|Gene Symbol and Name||Otx1, orthodenticle homeobox 1|
|Strain of Origin||C57BL/6J|
|Molecular Note||Jackson Waltzer was found to be an allele at the Otx1 locus through complementation testing with Otx1tm1Asim.|
When using the Jackson waltzer mouse strain in a publication, please cite the originating article(s) and include JAX stock #000531 in your Materials and Methods section.