The glutamate receptor delta2 (Grid2) gene is predominantly expressed in the postsynaptic densities of parallel fiber-Purkinje cell synapses and plays a crucial role in cerebellar function. Many mutations have been found for this gene, and while several hotfoot spontaneous mutations involve deletions of one or more exons in the Grid2 gene, the Grid2ho-5J hotfoot mutation has been shown to be a point mutation.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Grid2 | glutamate receptor, ionotropic, delta 2 |
The glutamate receptor delta2 (Grid2) gene is predominantly expressed in the postsynaptic densities of parallel fiber-Purkinje cell synapses and plays a crucial role in cerebellar function. Many mutations have been found for this gene, and while several hotfoot spontaneous mutations involve deletions of one or more exons in the Grid2 gene, the Grid2ho-5J hotfoot mutation has been shown to be a point mutation.
Embryos produced by crossing heterozygous Grid2ho-5J males to C57BL/6J females were cryopreserved in 1982.
Allele Name | hotfoot 5 Jackson |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Grid2, glutamate receptor, ionotropic, delta 2 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 6 |
Molecular Note | RT-PCR revealed a single nucleotide deletion at position 1999 in exon 12 near the beginning of the region encoding TM3. This causes a frame shift leading to a stop codon in the middle of TM3. |
When using the hotfoot 5 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #000527 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Grid2<ho-5J> |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.