Mutants can be distinguished by folds of body skin at about one week of age. Then the coat grows normally until about four weeks of age when it becomes sparse on the head and neck. Regrowth may occur, but after six weeks hair loss is progressive. Old animals are almost naked and usually become blind by six months. Both homozygotes and heterozygotes are viable and healthy.
|Gene Symbol and Name||Gsdma3, gasdermin A3|
|Strain of Origin||B10.129/(11M)Sn|
|Molecular Note||A 6 bp insertion (AAGCGG) in exon 12, starting at nucleotide 1314, results in a duplication of codons 411 and 412, creating a Glu Ala Glu Ala sequence from codons 411-414.|