These mice carry a spontaneous remutation at the Foxn1 locus characterized by hairlessness and lack of a thymus.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Foxn1 | forkhead box N1 |
Mice homozygous for the streaker spontaneous have a phenotype that is very similar to nude mice.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
The Foxn1nu-str remutation occurred in the AKR/J inbred strain. Embryos produced by mating heterozygous B6.AK-Foxn1nu-str/J males to C57BL/6J females were cryopreserved in 1981.
Allele Name | nude streaker |
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Allele Type | Spontaneous |
Allele Synonym(s) | nustr |
Gene Symbol and Name | Foxn1, forkhead box N1 |
Gene Synonym(s) | |
Strain of Origin | AKR/J |
Chromosome | 11 |
Molecular Note | A spontaneous mutation to nude called streaker arose in the AKR/J strain in 1974 at The Jackson Laboratory. An allele test confirmed that streaker is an allele of nude. |
When using the nude streaker mouse strain in a publication, please cite the originating article(s) and include JAX stock #000521 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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