B6.AK-Foxn1^nu-str/J

Stock number: 000521
Product name: nude streaker
Research areas: Dermatology Research, Immunology, Inflammation and Autoimmunity Research

Description

These mice carry a spontaneous remutation at the Foxn1 locus characterized by hairlessness and lack of a thymus.

Detailed description

Mice homozygous for the streaker spontaneous have a phenotype that is very similar to nude mice.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development

The Foxn1^nu-str remutation occurred in the AKR/J inbred strain. Embryos produced by mating heterozygous B6.AK-Foxn1^nu-str/J males to C57BL/6J females were cryopreserved in 1981.

Allele

Symbol: Foxn1^nu-str
Name: nude streaker
MGI accession ID: MGI:1856109
Generation method: Spontaneous
Marker symbol: Foxn1
Marker name: forkhead box N1
Chromosome: 11
Strain of origin: AKR/J
Molecular note: A spontaneous mutation to nude called streaker arose in the AKR/J strain in 1974 at The Jackson Laboratory. An allele test confirmed that streaker is an allele of nude.