Mice homozygous for the streaker spontaneous have a phenotype that is very similar to nude mice.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
The Foxn1nu-str remutation occurred in the AKR/J inbred strain. Embryos produced by mating heterozygous B6.AK-Foxn1nu-str/J males to C57BL/6J females were cryopreserved in 1981.
|Allele Name||nude streaker|
|Gene Symbol and Name||Foxn1, forkhead box N1|
|Strain of Origin||AKR/J|
|Molecular Note||A spontaneous mutation to nude called streaker arose in the AKR/J strain in 1974 at The Jackson Laboratory. An allele test confirmed that streaker is an allele of nude.|