C57BL/10ScSn is a substrain of C57BL, which is one of the most widely used inbred strains. Coat color is black (non-agouti) a/a. The C57BL/10ScSn substrain was separated from the C57BL/10J substrain at F26, when it was transferred to J.P. Scott. At F35-36, it was transferred to George Snell, thus acquiring the informal designation "Scotty Snell" or "Scott Snells". C57BL/10ScSn mice have low brain glutamic acid decarboxylase. Except for this and some minor behavioral differences, they are similar to the C57BL/10J substrain. Cheers and McKenzie found this strain to be resistant to listeriosis

This C57BL substrain, "Scotty Snell", is the most common genetic background for histocompatibility congenic and mutant strains created by George Snell and others. It serves as an appropriate genetic background control for the Duchenne muscular dystrophy strain, C57BL/10ScSn-Dmdmdx/J (Stock No. <a href="https://www.jax.org/strain/001801">001801</a>).

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